A new Nature Communications article sheds light into the mechanisms that govern programmed ribosomal frameshifting (PRF) in SARS-CoV-2 virus, as demonstrated by C-Trap experiments.
j.yeh13 December 2021
A recent work published in eLife by Francisco de Asis Balaguer et al. shed light on the interaction of ParB with DNA, the consequent DNA condensation, and the role of cytidine triphosphate (CTP) in this process – at a single-molecule level. Using the C-Trap® the researchers investigated the role of…
j.yeh30 November 2021
The Technical University of Munich, Germany, is now the home of two C-Trap® Optical Tweezers – Fluorescence Microscopes. With this second installation, the renowned lab of Prof. Matthias Rief is taking their dynamic single-molecule research to the next level. Prof. Rief is a pioneer in studying processes involved in protein…
j.yeh24 November 2021
A recent study by Szu‐Ning Lin et al. for the first time provided direct information on the dynamics of the interaction between HU and DNA and how this interaction is influenced by ionic conditions and DNA conformation.
j.yeh9 November 2021
A recent publication by Losito et al. from the lab of Prof. David Rueda (Imperial College London), reveals new information on the kinetics and mechanism of Cas12a-DNA interaction.
j.yeh13 October 2021
A recent publication by Kucera et al. in Nature Communications combined TIRF assays and Optical Tweezers measurements to investigate myosin-independent actin contraction that is relevant during cytokinesis and cell division. The authors found a new mechanism showing how anillin, a non-motor actin crosslinking and scaffolding protein, substitutes for the activity…
j.yeh23 August 2021
In a recent article published in Science Advances, researchers investigated the mechanical consequences of a missense mutation within a highly conserved region, P305L, in the kinesin motor family member A1 (KIF1A). By employing a single-molecule approach using the C-Trap® as well as biochemical and genetic assays, Lam et al. found…
j.yeh15 July 2021
We’re overjoyed to announce the placement of one of our most sophisticated C-Trap® systems at the newly formed Center for Optical Bio-Manipulation (COBM) at the Niels Bohr Institute, University of Copenhagen! The center is based around LUMICKS' C-Trap system, flaunting quadruple optical tweezers, 3 color confocal fluorescence microscopy, and STED…
Adrià Ferragut13 July 2021
We are delighted to announce two new C-Trap® installations in Europe, one at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the other at the University of Kent. At MPI-CBG, this will be the second C-Trap installed. The new system is configured with quadruple optical traps…
Adrià Ferragut6 July 2021
A recent article published in the Journal of Physical Chemistry Letters provides insight into the stability and folding dynamics of RNA G-quadruplexes (RG4). Using the C-Trap® optical tweezers, Ye et al. investigated the influence of a proximal single-stranded (ss) RNA sequence and found that its existence significantly impairs RG4 stability.…
j.yeh24 June 2021
