optical tweezers dna repair force extension manipulation visualization RAD51 Recombination

Investigation of the Interaction of RAD51 with ssDNA Using CTFM and X-ray Crystallography

Recently, the paper “Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA” has been published in The EMBO Journal. Congratulations to Dr. Ineke Brouwer and all co-authors! Brouwer et al. combined Correlative Optical Tweezers-Fluorescence Microscopy (CTFM) … Continue Reading

strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cell

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper “Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase”. We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine … Continue Reading

multiple trap optical tweezers - fluorescence microscopy

New C-Trap™ acquired by the University of Göttingen

A new C-Trap™ system has recently been acquired by the Georg August University in Göttingen, Germany. The C-Trap™ was successfully installed in the lab of the “Nanoscale Imaging of Cellular Dynamics” research group, led by Prof. Dr. Sarah Köster, at the … Continue Reading

optical-tweezers-fibrin-fibers

Effect of Mechanical Stress on Individual Vimentin Filaments Studied using the C-Trap™

The paper “Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain” using LUMICKS’ C-Trap™ has recently been published in Physical Review Letters. Congratulations to all the authors! The study led by Prof. Sarah Köster, investigated the mechanical … Continue Reading

C-Trap™ Installed at Rockefeller University

LUMICKS is proud to announce that a C-Trap™ optical tweezers-fluorescence microscopy system was installed at Rockefeller University in the Liu Lab led by Assistant Professor Shixin Liu. Dr. Liu wil use the C-Trap™ to study how cells execute replication, transcription, translation and … Read More

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Customer Case Story MPI-CBG Dresden

In March 2016 LUMICKS delivered a C-Trap™ correlative optical tweezers – fluorescence microscopy instrument to the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden. The instrument was acquired at the end of 2015 by a group … Continue Reading

optical-tweezers-fluorescence-microscopy-groningen

C-Trap™ Installation at University of Groningen

LUMICKS is proud to announce that we successfully installed a C-Trap™ at the University of Groningen in the lab of professor Roos. The Roos group will use the optical tweezers-fluorescence microscopy system to investigate the structure and mechanics of viral … Continue Reading

microfluidics-pressure-box

u-Flux™ Microfluidics System Updated with Improved Pressure Box

LUMICKS is proud to announce the release of the upgraded u-Flux™ microfluidics system. This version of the u-Flux™ includes an improved pressure box, which allows the user to readily and easily perform single-molecule experiments in a laminar flow environment. Not … Continue Reading

optical-tweezers-fibrin-fibers

Interactions between Single Fibrin Fibers are Measured for the First Time

Cells and tissue change their structural properties to cope with large strains e.g. caused by blood flow and external stress. Understanding microstructural remodeling of the extracellular matrix requires knowledge of biological events down to the smallest scale. One of the … Continue Reading

DNA-repair-Nature

Paper Using LUMICKS Technology Published in Nature

Great news: Another paper using LUMICKS technology was published, this time in Nature! Congratulations to the authors. Several are now part of LUMICKS. In the study “Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA” Brouwer et al. … Continue Reading