Article Archives

Blog posts

C-Trap^® experiments reveal novel mechanism for transcription termination in bacteria

New insights into the regulation of transcription termination have been revealed by researchers from the lab of Shixin Liu at The Rockefeller University, New York, in a recent publication in Molecular Cell. Using the powerful LUMICKS C-Trap® technology that allows the direct observation of molecular mechanisms, they were able to…

Rozina Kardakaris31 March 2023

Blog posts

100th study using the C-Trap^® provides crucial insights into how the Smc5/6 complex stabilizes certain DNA structures

A recent study published in Nature Communications led by Shixin Liu from The Rockefeller University, New York, demonstrates how the C-Trap® can be used to directly visualize and observe molecular mechanisms in action, leading to better and faster insights into critical molecular processes. This study marks an important milestone for LUMICKS,…

Rozina Kardakaris28 March 2023

Blog posts

C-Trap^® experiments shed light on the mechanisms that govern Structural Maintenance of Chromosome (SMC) Complexes

In two recent scientific publications, Johannes Stigler and his team from the Gene Center of the Ludwig-Maximilians-University Munich, Germany, set out to mechanistically describe the action of the Structural Maintenance of Chromosome (SMC) Complexes using LUMICKS’ C-Trap® technology. By performing dynamic single-molecule experiments coupled with real-time visualization, they were able…

Rozina Kardakaris9 March 2023

Blog posts

Unlocking the secrets of DNA-binding proteins in nuclear extracts using dynamic single-molecule analysis

For a long time, scientists have been striving to understand how DNA-binding proteins interact with DNA substrates in real time at the single-molecule level, using a variety of imaging techniques and optical platforms. However, for most of these methods scientists always had to choose between studying purified proteins under specific…

Rozina Kardakaris28 February 2023

Blog posts

C-Trap^® experiments highlight the potential of POLQ inhibitors as BRCA-deficient cancer therapeutics

Double-stranded breaks (DSBs) are among the most serious and lethal types of DNA damage known that can lead to cell death and cancer. POLQ is an enzyme in humans that we know plays a crucial role in DSB repair and is overexpressed in many types of cancer, promoting cancer cell…

Rozina Kardakaris6 February 2023

Blog posts

Transcription factors and chromatin co-condensate and generate forces that alter genomic structure and function

Researchers led by Yael David and Shixin Liu have published a Nature Communications study describing for the first time the mechanisms underlying the co-condensation between transcription factors and DNA. By performing dynamic single-molecule experiments using LUMICKS’ C-Trap® technology, they were able to prove the physiological importance of phase-separated sub-compartments (co-condensates)…

Rozina Kardakaris7 December 2022

Blog posts

Dynamic single-molecule experiments expose catch bonds as key to cell strength and flexibility

In a recent Nature Materials publication, scientists show for the first time how certain types of molecular bonds known as “catch bonds” make it possible for cells to combine both mechanical strength to withstand forces and adaptability to change shape and move. By performing dynamic single-molecule experiments with LUMICKS’ C-Trap®,…

Rozina Kardakaris13 October 2022

Blog posts

C-Trap^® experiments suggest tubulin lattice state dictates tau envelope formation

Tau is an intrinsically disordered microtubule-associated protein (MAP) that helps stabilize microtubules by forming an envelope around them. This stabilizing protein has been implicated in neurodegenerative diseases such as Alzheimer’s, where abnormal chemical changes promote detachment of tau from microtubules and the formation of long threads that eventually lead to…

Rozina Kardakaris22 September 2022

Blog posts

m-Trap^® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

Until recently, the understanding of membraneless organelles (MLOs) was hindered by the inability to control their bioactivities in a precise manner. In a recent Nature Communications article from the lab of Huang and Sun, University of Hong Kong, researchers were able to overcome this obstacle by producing synthetic MLOs that…

j.yeh23 August 2022

Blog posts

Dynamic single-molecule analysis reveals non-linear stiffening of mitotic chromosomes

In a recent study performed by Vrije Universiteit Amsterdam and the University of Copenhagen, researchers used LUMICKS’ u-Flux™ laminar flow microfluidics system together with optical tweezers and fluorescence microscopy – features combined in LUMICKS’ C-Trap® – to shed light on the structural organization of mitotic chromosomes. When preparing to undergo…

Rozina Kardakaris17 June 2022

Join our newsletter

First Name

Last Name

E-mail address *

Country

Get exclusive news on the latest publications, product developments, events and breakthrough science.

Application of interest *

Dynamic single-molecule analysis

Cell avidity analysis

By submitting the form you agree to LUMICKS' privacy policy. You can revoke your consent at any time.

Cookie	Duration	Description
cookielawinfo-checkbox-advertisement	1 year	Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .
cookielawinfo-checkbox-analytics	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
CookieLawInfoConsent	1 year	Records the default button state of the corresponding category & the status of CCPA. It works only in coordination with the primary cookie.
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.

Cookie	Duration	Description
_ga	2 years	The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
_gat_gtag_UA_57399829_1	1 minute	Set by Google to distinguish users.
_gat_UA-57399829-1	1 minute	A variation of the _gat cookie set by Google Analytics and Google Tag Manager to allow website owners to track visitor behaviour and measure site performance. The pattern element in the name contains the unique identity number of the account or website it relates to.
_gcl_au	3 months	Provided by Google Tag Manager to experiment advertisement efficiency of websites using their services.
_gid	1 day	Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
pardot	past	The pardot cookie is set while the visitor is logged in as a Pardot user. The cookie indicates an active session and is not used for tracking.

Cookie	Duration	Description
boxzilla_box_8601	3 days	No description
lpv970813	30 minutes	No description
visitor_id970813	1 year	No description
visitor_id970813-hash	1 year	No description

Applications

Products

Science

Company

Article Archives - LUMICKS

C-Trap^® experiments reveal novel mechanism for transcription termination in bacteria

100th study using the C-Trap^® provides crucial insights into how the Smc5/6 complex stabilizes certain DNA structures

C-Trap^® experiments shed light on the mechanisms that govern Structural Maintenance of Chromosome (SMC) Complexes

Unlocking the secrets of DNA-binding proteins in nuclear extracts using dynamic single-molecule analysis

C-Trap^® experiments highlight the potential of POLQ inhibitors as BRCA-deficient cancer therapeutics

Transcription factors and chromatin co-condensate and generate forces that alter genomic structure and function

Dynamic single-molecule experiments expose catch bonds as key to cell strength and flexibility

C-Trap^® experiments suggest tubulin lattice state dictates tau envelope formation

m-Trap^® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

Dynamic single-molecule analysis reveals non-linear stiffening of mitotic chromosomes

Recent Posts

Yearly Archive

Applications

Products

About LUMICKS

For pricing, reach out to your application scientist or account manager

Fill in our contact form, we will reach out to you!

Join our newsletter

Download our webinar recording:

Download our Cell Therapy (CAR-T, TCR, NK) applications deck

Applications

Products

Science

Company

Article Archives - LUMICKS

Recent Posts

Yearly Archive

Tags

Applications

Products

About LUMICKS

For pricing, reach out to your application scientist or account manager

Fill in our contact form, we will reach out to you!

Join our newsletter

Download our webinar recording:

Download our Cell Therapy (CAR-T, TCR, NK) applications deck