DNA Breathing

DNA Breathing Application Note Now Online

DNA breathing, also known as fraying, describes the spontaneous local conformational transitions occurring within double-stranded DNA (dsDNA). Due to the transient and spontaneous nature of this process, the study of real-time DNA breathing transitions at the single-molecule level requires the use of highly … Read More

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strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cell

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper “Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase”. We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine … Read More

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BIOCEV customer case story - Academy of Sciences of the Czech Republic, Faculty of Science and the First Faculty of Medicine of the Charles University in Prague

Customer Case Story BIOCEV Prague

In January 2016, LUMICKS’ first C-Trap™ Optical Tweezers-Fluorescence Microscopy instrument was successfully installed at the BIOCEV research center in the Czech Republic. BIOCEV is a research institute in the areas of biotechnology and biomedicine of both the Academy of Sciences … Read More

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cytoskeleton filament manipulation using optical tweezers fluorescence microscopy

Filament Manipulation Application Note Now Online

Protein filaments have been studied indirectly using various approaches of fluorescence microscopy in cells and tissues and more directly, using force spectroscopy on single filaments or filament bundles. LUMICKS’ C-Trap™ provides for a unique approach which combines the strength of … Read More

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acoustic-force-spectroscopy-cell-mechanobiology-2

Investigation of the Integration of AFS™ with Digital Holography Imaging

The research article “Digital holography as 3D tracking tool for assessing acoustophoretic particle manipulation” has recently been published in Optics Express Journal. Congratulations to all the authors! By making use of the AFS™ chip, Cacace et al. (2017) investigated the integration of digital holography (DH) imaging … Read More

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C-Trap Chemical Reviews AFS Biochemical Society Transactions

C-Trap™ and AFS™ systems mentioned in two review articles

We are proud to announce that two review articles refer to LUMICKS; one highlighting the C-Trap™ Optical Tweezers-Fluorescence Microscopy system and the other one specifying the AFS™ Acoustic Force Spectroscopy system.  Norregaard et al. (2017) reviews relevant theoretical tools to analyze data obtained from single-molecule … Read More

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Optical Tweezers-Fluorescence Microscopy Workshop at LUMICKS’ headquarters

On June 20 and 21, LUMICKS organized a successful workshop on Optical Tweezers-Fluorescence Microscopy & Acoustic Force Spectroscopy at our headquarters in Amsterdam. During the practical hands-on workshop, our application scientists gave demonstrations on the latest developments and applications of … Read More

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Acoustic force spectroscopy Pasteur Institute Paris Thierry Rose

AFS™ Installed at Pasteur Institute in Paris

The first  AFS™ system in France has been successfully installed at the lab of Dr. Thierry Rose at the Pasteur Institute in Paris. Dr. Rose and his team use AFS to manipulate human lymphocytes in living conditions to gain insights … Read More

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multiple trap optical tweezers - fluorescence microscopy

New C-Trap™ acquired by the University of Göttingen

A new C-Trap™ system has recently been acquired by the Georg August University in Göttingen, Germany. The C-Trap™ was successfully installed in the lab of the “Nanoscale Imaging of Cellular Dynamics” research group, led by Prof. Dr. Sarah Köster, at the … Read More

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Acoustic Force Spectroscopy Protein Unfolding Application Note high throughput

AFS Protein Unfolding Application Note Now Online

Single-molecule force spectroscopy (SMFS) technologies have become prominent as powerful tools for the investigation of the biomechanics associated with protein structure and for the study of protein unfolding pathways. However, current SMFS tools lack the ability to study multiple protein … Read More

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