Study shows how chaperone enzyme ClpB processively translocates polypeptide loops using C-Trap correlated optical tweezers and confocal microscopy

A new study published in Nature reports how researchers verified the intricate process of disaggregating entangled proteins by analyzing chaperone enzyme ClpB at a single-molecule level. The C-Trap® correlated optical tweezers and confocal microscopy enabled them to analyze how the … Continue Reading

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C-Trap® installed at Technical University of Munich

We are happy to announce the recent installation of the C-Trap® at the Technical University of Munich, Germany, in the lab of Prof. Matthias Rief. The installed C-Trap combines optical tweezers with 2-color fluorescence microscopy and will be used by … Read More

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Dynamic Single-Molecule Workshops in North and South of China

Last week we organized two dynamic single-molecule workshops in the North and South of China – one at Tsinghua University in Beijing, and another at  Sun Yat-sen University (SYSU). Both workshops included in-depth lectures exploring different state-of-the-art single-molecule applications and hands-on demonstrations … Read More

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C-Trap™ installed at Tel Aviv University

  We are happy to announce the recent installation of the C-Trap™ at Tel Aviv University, Israel, in the lab of Dr. Raya Sorkin. The C-Trap combines optical tweezers with confocal microscopy and is now available to students and postdocs … Continue Reading

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Single-molecule study assesses how cohesin complexes bridge DNA molecules using C-Trap correlated optical tweezers with fluorescence microscopy

In a new study published in the journal Science Advances, Gutierrez-Escribano et al. studied the role of cohesin complexes in DNA tethering to gain a better understanding of sister chromatid cohesion. Using the C-Trap correlated optical tweezers with fluorescence microscopy, they … Read More

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New application note shows how to study processes associated with phase separation in real time using the C-Trap™

We are excited to tell you that our application note Manipulate and Study Protein Droplet Dynamics and Properties in Real Time to Understand Phase Separation is now available to download. Here, you can learn how to unravel the properties, formation, … Continue Reading

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Study finds essential Cas9–DNA interaction downstream of PAM using a single-molecule approach

A new publication shows how the lab of Dr. Bo Sun used the m-Trap™ to analyze the interactions between a Cas9–gRNA complex and DNA. Using a single-molecule approach to unzip the target double-stranded DNA, the team showed interaction points on the … Continue Reading

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C-Trap™ installed at University of Vermont

We are happy to announce the recent installation of the C-Trap™ at the University of Vermont Larner College of Medicine. Several labs will use the correlated optical tweezers – fluorescence microscopy instrument to investigate the dynamics of molecular machines that interact with … Read More

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C-Trap Albert Einstein College of Medicine

C-Trap™ installed at Albert Einstein College of Medicine

We are happy to announce the installation of the C-Trap™ at the Albert Einstein College of Medicine in New York in the lab of Prof. Dr. Arne Gennerich. The instrument combines optical tweezers with 3-color total internal reflection fluorescence (TIRF; … Continue Reading

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New application note shows how to study Cas9 target specificity at the single-molecule level using the C-Trap™

We are happy to announce that our application note Analyze Cas9 Binding and Cleavage Properties in Real Time while Manipulating DNA Structures is available to download on our website. In this application note, you can learn how the group of … Continue Reading

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