Evaluation of protein droplet viscoelasticity with the C-Trap® reveals new material properties

A recent publication in Science describes a new glass-like structural behavior that protein droplets can adopt, regulating their biochemical behavior as they age. Specifically, through rheological measurements using the C-Trap® optical tweezers, the researchers discovered material properties that may help cells … Continue Reading

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Coordinated stimulation of RAD51 filament assembly and growth revealed with the C-Trap®

A recent study published in Molecular Cell used dynamic single-molecule analysis to evaluate the roles of specific proteins involved in the initiating steps of homologous recombination, including nucleation and growth of RAD51 filaments. Specifically, the researchers used the C-Trap® optical … Continue Reading

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Measure Cell Mechanics with Acoustic Force Spectroscopy

Researchers study the viscoelasticity of human cells as a response to external cues using the high-throughput AFS®

A recent publication in Small introduces you to the value of acoustic force spectroscopy (AFS®) to study the viscoelastic properties of individual cells in high throughput. The authors describe how they used this “plug-and-play” instrument to measure mechanical cell properties … Continue Reading

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Distal bridging between nucleosomes by polycomb complex PRC2 identified with the C-Trap®

A recent study published in PNAS used single-molecule force spectroscopy to examine unknown interaction mechanisms between polycomb repressive complex 2 (PRC2) and chromatin. The authors evaluated arrays of multiple nucleosomes using their C-Trap® optical tweezers system and identified distal nucleosome … Continue Reading

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C-Trap® installed at Emory University in Atlanta

We are happy to announce the installation of a new C-Trap® system with correlated optical tweezers and three-color confocal imaging functionality at Emory University in Atlanta, Georgia. The installed instrument, which is managed by the research group of Prof. Laura … Read More

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New study highlights interconvertible RecA–ssDNA states with the help of u-Flux™ microfluidics

A recent publication in FEBS Letters describes how the presence of ADP and ATP affects the structural transitions that single-stranded DNA (ssDNA) undergoes upon RecA-filament assembly. The researchers used the u-Flux™ Laminar Flow Microfluidics combined with optical tweezers to demonstrate … Continue Reading

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Force-dependent actin filament-binding by α-catenin recorded with the C-Trap®

A recent publication in the journal eLife describes a multidisciplinary study evaluating how the mechanical properties of actin filaments regulate the binding of associated proteins. Specifically, the researchers used the C-Trap® to demonstrate how applied forces on actin filaments enhance … Continue Reading

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Madrid

C-Trap® installed at the National Center for Biotechnology in Madrid

We are happy to announce the installation of a C-Trap® Optical Tweezers – Fluorescence and Label-free Microscopy system at the National Center for Biotechnology (CNB), Madrid, managed by the lab of Dr. Fernando Moreno-Herrero. The team will use the C-Trap … Continue Reading

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LinkedIn Top Startups 2020

LUMICKS featured in LinkedIn Top Start-ups 2020

LUMICKS reached the 6th position in the list LinkedIn Top Start-ups 2020 in the Netherlands. We’re extremely proud to be among the most resilient companies during these changing times. The LinkedIn editors define start-ups as privately held companies, that are no … Continue Reading

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New application note shows how to study transient conformational changes of kinases using the C-Trap®

We are excited to announce that our latest application note, Real-time detection of kinase conformational changes in the presence of a small-molecule inhibitor, is available to download. The application note is perfect for protein research, as it showcases how you … Continue Reading

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