In a new study published in the journal Science Advances, Gutierrez-Escribano et al. studied the role of cohesin complexes in DNA tethering to gain a better understanding of sister chromatid cohesion. Using the C-Trap correlated optical tweezers with fluorescence microscopy, they … Read More
News
General news, product installations and the latest articles regarding our technologies
New application note shows how to study processes associated with phase separation in real time using the C-Trap™
We are excited to tell you that our application note Manipulate and Study Protein Droplet Dynamics and Properties in Real Time to Understand Phase Separation is now available to download. Here, you can learn how to unravel the properties, formation, … Continue Reading
Study finds essential Cas9–DNA interaction downstream of PAM using a single-molecule approach
A new publication shows how the lab of Dr. Bo Sun used the m-Trap™ to analyze the interactions between a Cas9–gRNA complex and DNA. Using a single-molecule approach to unzip the target double-stranded DNA, the team showed interaction points on the … Continue Reading
C-Trap™ installed at University of Vermont
We are happy to announce the recent installation of the C-Trap™ at the University of Vermont Larner College of Medicine. Several labs will use the correlated optical tweezers – fluorescence microscopy instrument to investigate the dynamics of molecular machines that interact with … Read More
C-Trap™ installed at Albert Einstein College of Medicine
We are happy to announce the installation of the C-Trap™ at the Albert Einstein College of Medicine in New York in the lab of Prof. Dr. Arne Gennerich. The instrument combines optical tweezers with 3-color total internal reflection fluorescence (TIRF; … Continue Reading
New application note shows how to study Cas9 target specificity at the single-molecule level using the C-Trap™
We are happy to announce that our application note Analyze Cas9 Binding and Cleavage Properties in Real Time while Manipulating DNA Structures is available to download on our website. In this application note, you can learn how the group of … Continue Reading
Study establishes molecular forces responsible for condensation of ribonucleoprotein-RNA complexes
Researchers investigated the molecular driving forces underlying the condensation and decondensation of ribonucleoproteins using the C-Trap™. Specifically, they showed that sequence-dependent features of the RNA and ribonucleoprotein molecules partially dictate phase transitions. These findings can help scientists further understand the … Continue Reading
New study maps internal and external structures of red blood cell aggregates by combining AFS™ and 3D imaging
Researchers used acoustic force spectroscopy (AFS™) in combination with 3D imaging to induce clustering and rotation of red blood cells, enabling them to study the properties of cell aggregates. The new approach, which is based on radiation and stream forces, … Continue Reading
New study evaluates the dynamics behind viral assembly at the single-molecule level using both C-Trap™ and AFS™
Researchers used the C-Trap™ optical tweezers – fluorescence microscopy system and acoustic force spectroscopy (AFS) to study the processes underlying viral assembly. The study evaluated the capsid formation and DNA condensation of virus-like particles (VLPs) at the single-molecule level and … Continue Reading
First Dynamic Single-Molecule Summer School in China!
Yet another premiere! LUMICKS organized the very first Dynamic Single-Molecule Summer School at Tsinghua University in Beijing. During the three-day event, nineteen participants received in-depth training in both the theory and practice of dynamic single-molecule (DSM) techniques. Our application scientists dedicated … Read More