Electrostatic effects on vimentin stiffness demonstrated with the C-Trap

A recently published study from the lab of Prof. Sarah Köster at the University of Göttingen investigated how electrostatic conditions influence the mechanical properties of intermediate filament vimentin, such as structural stability. The researchers assessed these features by stretching the … Continue Reading

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Cell avidity is a superior predictor of CAR T-cell efficacy in myeloma than cytotoxicity – first published z-Movi® results

We are proud to announce the first publication showing results from cell–cell interaction measurements using the z-Movi® Cell Avidity Analyzer! In the study, Fernández de Larrea et al. demonstrate how cell avidity between CAR T cells and target multiple myeloma … Continue Reading

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In vitro characterization of nucleosomes upon DNA unwrapping using the C-Trap®

A recent publication in the journal Scientific Reports describes a new method to create arrays of nucleosome positioning motifs. Through sequential Gibson Assembly reactions, the researchers managed to clone a series of sequence motifs, with high affinity for histone octamers, … Continue Reading

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Vesicle-like RNA–protein condensates characterized by the C-Trap®

We were happy to find yet another publication from the lab of Dr. Priya Banerjee with results from C-Trap® analyses! This time his lab examined the formation and features of vesicle-like RNA–protein structures, which differ from the more known uniform … Continue Reading

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Exploring mitochondrial translation processes with the C-Trap®

This month, we find the C-Trap®  featured in Nature Communications in an article published by the lab of Dr. Joanna Rorbach in which they describe mitochondrial translation initiation. The study provides insight into a relatively unexplored, yet exciting field that … Continue Reading

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Recent review highlights the impact of force spectroscopy and the C-Trap

We were happy to read last week that LUMICKS was recognized for our efforts in the field of dynamic single-molecule research! A recent review in ACS Publications examined the current advances in single-molecule research, highlighting the impact of force spectroscopy … Continue Reading

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Single-molecule measurements with AFS® and optical tweezers reveal progressive assembly of viruses

The research lab of Dr. Gijs Wuite in the Netherlands recently published a single-molecule study in Science Advances, demonstrating the progressive self-assembly steps of viruses. Methods, such as optical tweezers and acoustic force spectroscopy (AFS®), enabled the researchers to study … Continue Reading

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Dutch Tech Heroes Fighting COVID-19 | LUMICKS

LUMICKS featured in Dutch Tech Heroes Fighting COVID-19

LUMICKS has been featured as one of the 150+ companies in the overview of Dutch Tech Heroes Fighting COVID-19 published by Techleap.nl. The Dutch non-profit organization states: In the current crisis, the Netherlands is increasingly dependent on digital and technological solutions from … Continue Reading

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New insights into the initiation of nucleotide excision repair found using C-Trap

A recent publication in PNAS shows how the catalytically inactive alkyltransferase-like protein (ATL) scans and recognizes detrimental DNA alkylation lesions. The C-Trap® with correlated optical tweezers and confocal microscopy enabled researchers to investigate how ATL interacts with DNA to identify … Continue Reading

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Screening of cancer targeting TCRs with the z-Movi®

With the quick development of new single-cell analysis technologies it is now possible to identify cancer-targeting T-Cell Receptors (TCRs) in a single experiment. A recent review published in Methods in Enzymology, presented the z-Movi® Cell Avidity Analyzer among the future … Continue Reading

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