New mechanism of helicase-induced DNA unwinding from nicks found with the C-Trap

A study published in eLife shows how replication protein A (RPA) activates helicase Bloom syndrome protein (BLM) to unwind double-stranded DNA (dsDNA) bidirectionally from nicks. The C-Trap® enabled the researchers to simultaneously measure and visualize the DNA–protein interactions in real … Continue Reading

Featured Post

Controlled ligand gradient through C-Trap facilitates DSM measurements

A publication in the journal Micromachines describes how researchers managed to control the concentrations of DNA-binding dyes in single-molecule optical tweezers experiments on DNA. They established a controlled concentration gradient with the multi-channel laminar microfluidics system integrated with their C-Trap® … Continue Reading

Featured Post

Impressions from LUMICKS’ Training Session for new users

As part of our commitment to support scientists through all the stages towards their first publication using our instruments, we often organize dedicated training sessions. In the case of the lab of Prof. Shi at Tsinghua University, this was in … Read More

Featured Post

Study shows detailed properties of Ca2+ sensors during membrane fusion

A recent study in the Biophysical Journal shows how a Dutch research group measured and visualized dynamic interactions between membranes in the presence of Ca2+ sensors and synaptic inducers Syt1 and Doc2b. With the combined optical tweezers and confocal fluorescence … Continue Reading

Featured Post
LUMICKS Top 250 Scale-ups

LUMICKS in Top 250 Scale-ups 2020 of the Netherlands!

We’re proud to be amongst the top 250 fastest growing scale-up companies in the Netherlands! Every year, the Erasmus Centre for Entrepreneurship (ECE) led by Prof. Dr. Justin Jansen, Academic Director of ECE and professor of Corporate Entrepreneurship at Rotterdam School of … Continue Reading

Featured Post

A new DNA–protein coupling procedure improves stability for DSM analyses

A recent study in Communications Chemistry shows how a research lab at AMOLF in the Netherlands optimized DNA–protein coupling to study dynamic processes requiring high forces and long-term assessments. Using their C-Trap® Optical Tweezers – Fluorescence Microscopy system, the team … Continue Reading

Featured Post

Dynamic Single-Molecule Webinar series this March

LUMICKS invites you to attend our Dynamic Single-Molecule (DSM) webinars in March! The series of webinars include topics in DNA editing, phase separation, protein unfolding, cytoskeleton filaments, and viral packaging. Here you will learn about state-of-art dynamic single-molecule techniques, their … Continue Reading

Featured Post

Study shows how chaperone enzyme ClpB processively translocates polypeptide loops using C-Trap correlated optical tweezers and confocal microscopy

A new study published in Nature reports how researchers verified the intricate process of disaggregating entangled proteins by analyzing chaperone enzyme ClpB at a single-molecule level. The C-Trap® correlated optical tweezers and confocal microscopy enabled them to analyze how the … Continue Reading

Featured Post

C-Trap® installed at Technical University of Munich

We are happy to announce the recent installation of the C-Trap® at the Technical University of Munich, Germany, in the lab of Prof. Matthias Rief. The installed C-Trap combines optical tweezers with 2-color fluorescence microscopy and will be used by … Read More

Featured Post

Dynamic Single-Molecule Workshops in North and South of China

Last week we organized two dynamic single-molecule workshops in the North and South of China – one at Tsinghua University in Beijing, and another at  Sun Yat-sen University (SYSU). Both workshops included in-depth lectures exploring different state-of-the-art single-molecule applications and hands-on demonstrations … Read More

Featured Post