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Transcription factors and chromatin co-condensate and generate forces that alter genomic structure and function

Researchers led by Yael David and Shixin Liu have published a Nature Communications study describing for the first time the mechanisms underlying the co-condensation between transcription factors and DNA. By performing dynamic single-molecule experiments using LUMICKS’ C-Trap® technology, they were able to prove the physiological importance of phase-separated sub-compartments (co-condensates)…

Rozina Kardakaris7 December 2022

Blog posts

Dynamic single-molecule experiments expose catch bonds as key to cell strength and flexibility

In a recent Nature Materials publication, scientists show for the first time how certain types of molecular bonds known as “catch bonds” make it possible for cells to combine both mechanical strength to withstand forces and adaptability to change shape and move. By performing dynamic single-molecule experiments with LUMICKS’ C-Trap®,…

Rozina Kardakaris13 October 2022

Blog posts

C-Trap® experiments suggest tubulin lattice state dictates tau envelope formation

Tau is an intrinsically disordered microtubule-associated protein (MAP) that helps stabilize microtubules by forming an envelope around them. This stabilizing protein has been implicated in neurodegenerative diseases such as Alzheimer’s, where abnormal chemical changes promote detachment of tau from microtubules and the formation of long threads that eventually lead to…

Rozina Kardakaris22 September 2022

Blog posts

m-Trap® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

Until recently, the understanding of membraneless organelles (MLOs) was hindered by the inability to control their bioactivities in a precise manner. In a recent Nature Communications article from the lab of Huang and Sun, University of Hong Kong, researchers were able to overcome this obstacle by producing synthetic MLOs that…

Nelli Bossert23 August 2022

Blog posts

LUMICKS’ C-Trap^® adopted by two labs at UBC

We are delighted to announce the installation of two C-Trap® instruments at the University of British Columbia (UBC), Vancouver, Canada, in the labs of Dr. Derek Dee and Dr. Nada Lallous. Derek Dee, Assistant Professor in the Department of Land and Food Systems, focuses his research on the forces that…

Rozina Kardakaris14 July 2022

Blog posts

Dynamic single-molecule analysis reveals non-linear stiffening of mitotic chromosomes

In a recent study performed by Vrije Universiteit Amsterdam and the University of Copenhagen, researchers used LUMICKS’ u-Flux™ laminar flow microfluidics system together with optical tweezers and fluorescence microscopy – features combined in LUMICKS’ C-Trap® – to shed light on the structural organization of mitotic chromosomes. When preparing to undergo…

Rozina Kardakaris17 June 2022

“Avidity Enhancement” As New Strategy for Improving CAR T Therapy for AML

Press releases

Cancer Cell Paper Identifies “Avidity Enhancement” As New Strategy for Improving CAR T Therapy for Acute Myeloid Leukemia

The study details a novel strategy for better cancer treatment with CAR T cells for AML. "Avidity Enhancement", increasing cell-cell binding from both the tumor and CAR T cell side, led to a more effective eradication of tumors in mouse models of AML.

j.yeh24 May 2022

Blog posts

C-Trap^® studies reveal GroEL-ES protein folding acceleration mechanism

In a recent Science Advances publication, the group of Sander J. Tans from the AMOLF Institute, The Netherlands, demonstrate for the first time, at the single molecule level, how the molecular chaperone GroEL-ES modulates protein chain collapse and stimulates protein folding. Using LUMICKS’ C-Trap®, they were able to follow and visualize…

Rozina Kardakaris17 May 2022

Press releases

LUMICKS Appoints Andre Nel as Chief Financial Officer

We are very pleased to attract an experienced life sciences financial executive like Andre to LUMICKS at this pivotal point in our growth. His seasoned expertise across large, global life science companies, including Illumina and Pfizer, will be invaluable to us as we accelerate our growth worldwide.

j.yeh9 May 2022

Press releases

Nature Paper Identifies “Avidity Escape” as Solid Tumor Evasion Mechanism of CAR T Cell Cancer Therapies

In this study led by the team of Dr. Marcela Maus at Harvard Medical School, the LUMICKS z-Movi® Cell Avidity Analyzer showed that loss of interferon-γ receptor (IFNγR) signaling decreased cell binding avidity between CAR T cells and their target solid tumor cells.

j.yeh2 May 2022

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Transcription factors and chromatin co-condensate and generate forces that alter genomic structure and function

Dynamic single-molecule experiments expose catch bonds as key to cell strength and flexibility

C-Trap® experiments suggest tubulin lattice state dictates tau envelope formation

m-Trap® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

LUMICKS’ C-Trap^® adopted by two labs at UBC

Dynamic single-molecule analysis reveals non-linear stiffening of mitotic chromosomes

Cancer Cell Paper Identifies “Avidity Enhancement” As New Strategy for Improving CAR T Therapy for Acute Myeloid Leukemia

C-Trap^® studies reveal GroEL-ES protein folding acceleration mechanism

LUMICKS Appoints Andre Nel as Chief Financial Officer

Nature Paper Identifies “Avidity Escape” as Solid Tumor Evasion Mechanism of CAR T Cell Cancer Therapies

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