m-Trap®

Optical Tweezers
Upgradable with Widefield Fluorescence Microscopy

m-Trap®

Optical Tweezers
Upgradable with Widefield Fluorescence Microscopy

The m-Trap® is the first entry-level optical tweezers instrument specifically developed for high resolution single-molecule research.

Ultra-high force resolution and stability, with incredible throughput, ease of use and modularity ‒ all at an unprecedented price level.

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What’s new?

Gain access to accessible, fast, and more reproducible than ever dynamic single-molecule (DSM) research using our ready-made consumables and tailored sample preparation services as well as a free, open-source user community scripting platform. Focus on your biological questions and generate the next wave of scientific discoveries in the least amount of time.

How does it work…

In 2018 Arthur Ashkin won the Nobel Prize in Physics for his discovery that the momentum of light can be used as an incredibly sensitive set of “tweezers”.

By shooting a laser through a microscope, he created a highly focused beam of light strong enough to trap and hold in place objects such as plastic beads. These beads can be coated to stick to a variety of biomolecules, such as proteins, cytoskeleton filaments, DNA or RNA. Furthermore, the tiniest forces applied to these molecules can be measured as well, giving the world access to a tool not only capable of manipulating biomolecules but also capable of detecting what’s happening to them.

Optical Tweezers Explained
Optical Tweezers Explained

…and how can it be applied to my research?

Whether you are aiming to make novel discoveries in the life sciences or develop successful drug candidates, we work on a personal level to find the right solution for you. Browse our extended list of applications to discover how these technologies can benefit your research.

Don’t see your specific field represented? Drop us an e-mail to see what we can do!

Stable and precise sample manipulation

Different optical tweezers configurations and advanced manipulation features that allow you to get the most out of your sample.

Dual (2)
Optical Traps

For your typical assay in solution

C-trap dual trap

Single (1)
Optical Trap

For highly stable surface assays

C-trap Single trap

Temperature Control

Perform your experiments under relevant conditions

Sample Stage

Ultra-precise measurements at the surface

Stable and precise sample manipulation

Different optical tweezers configurations and advanced manipulation features that allow you to get the most out of your sample.

Dual (2) Optical Traps

For your typical assay in solution

Single (1) Optical Trap

For highly stable surface assays

Temperature Control

Perform your experiments under relevant conditions

Sample Stage

Ultra-precise measurements at the surface

Visualization capabilities and integration with 3rd
party systems

Fully supported integration and correlation with widefield fluorescence microscopy and custom optical layout allowing for 3rd party system integration.

Widefield
Fluorescent
Imaging

Use Widefield microscopy to image biomolecular processes in solution with high acquisition rates. Suitable for obtaining fast movies of trapped constructs at low protein concentrations.

m-Trap Flex option

The m-Trap Flex option provides access to the optical path, allowing for the integration of custom hardware. Imaging and spectroscopy techniques can be added to the m-Trap offerring full flexibility to combine locally developed optical hardware with the m-Trap’s ultra-high force resolution and stability

High throughput experiment workflow

Loading your sample and analysing your data in less than 30 minutes.

Load your sample into the flow

With fast and simple pipetting

For solution assays, load your samples and conditions into the syringes of the 5-channel u-Flux™ Laminar Flow Microfluidics system. Pipetting each reagent takes seconds thanks to the twist-and-lock syringe adaptor, with which you can quickly and easily refill individual syringes.

C-Trap fluidics
C-Trap Cover slip

Assemble your assay without physical barriers

With our new nano stage option and using laminar flow microfluidics

For solution assays, you can seamlessly move your optical traps to gather reagents, move them between the 5 microfluidics lanes, and assemble your constructs.

For surface assays, double-click on a bead to trap it. You can easily locate your samples using, for example, IRM or fluorescence microscopy. The high-resolution piezo-controlled nanostage, allows you to accurately move between positions (x and y) to place the trapped bead at the end of the microtubule and start your experiment.

Workflow

In solution

Multiple adjacent laminar flow channels that do not mix (no physical barriers are involved). Use the traps to move between flows to pick up anything you like.

At the surface

Beads float in solution, while microtubules are at the surface. Bring them together using click-to-move optical traps and the new sample stage option.

Perform and automate your experiments

With our Bluelake software suite

Bluelake™ is an intuitive user-friendly software suite containing programs that simplify, automate, and enhance single-molecule experiments and real-time data gathering with a mouse click. For example, use Bluelake to:

  • Assemble your samples and run your experiment in 80 seconds.
  • Extract 18 sets of data in only 30 minutes.

Organise and analyze your data

With a dedicated software suite

Generate a structured experiment overview with a fast and smooth navigation through multiple days of measurements. View, compare, and export your fully correlated data stream during or after the experiment. The dedicated software automatically stores all your metadata so you never lose valuable information and always have the option to reproduce your experiments.

Analyzing and repeating experiments has never been easier, as our analysis software comes with tutorials and sample notebooks that can serve as a scaffold for your own analyses.

Kymotracker is a data analysis package that automatically tracks individual fluorescent traces on a recorded kymograph, allowing you to easily quantify protein-binding events and evaluate them over time.

Easy and intuitive software package

Check how you can completely automate your experiments using our user-centered software workflow.

Intuitive controls

Quick and easy sample interfacing

The software gives you total control over your experiments. Whether you are visually navigating through the laminar flow cell on the screen or selecting the area you wish to scan through the bright-field camera, our approach puts you in the front seat.

Fully correlated data

Everything in a single timeline

Bluelake was designed to control all aspects of your system from a single interface. The trap positions, force data, bright-field, fluorescence microscopy, and label-free images use the same software package, which truly correlates the experiments.

New:

Ready-made reagents, kits, and tailored sample preparation services

Use our newly-established biochemistry platform and internal expertise for the purification, labeling, and preparation of your reagents for optical trapping experiments. With our multidisciplinary expertise in molecular biology, biochemistry, and dynamic single-molecule analysis, we’ve created the most extensive selection of ready-made reagents, kits, and tailored services to prepare your samples.

 

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