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A new milestone for
single-molecule research.

Introducing: m-Trap™

 

Understanding the root causes of diseases at the molecular level is one of the greatest scientific challenges of today. Expanding the knowledge of biological processes that are at the basis of diseases is key for their prevention and the development of future cures. We aim to create the best possible tools for researchers to perform high-quality, high-throughput single-molecule experiments in the most accessible manner.

A new milestone for single-molecule research.

m-Trap™

Optical Tweezers

Introducing:

Watch the launch video

Unlocking single-molecule analysis

The m-Trap™ optical tweezers was developed to lower the price barrier of advanced single-molecule force spectroscopy instrumentation without compromising on performance characteristics.

We went back to the essence of force spectroscopy. Every single component, every process, has been considered and measured to be truly useful, and enhances the user’s experience. The m-Trap™ is capable of manipulating and characterizing structural transitions and interactions of biomolecules at the Angstrom scale with ultra-high force resolution, stability & throughput. Explore the applications to see what this technology can mean for you.

Key Specifications

Force-Distance Curves

Probe biomolecules and obtain insights into their mechanical properties with 0.1 pN force resolution.

Object Manipulation

Manipulate molecules with ease-of-use
and high throughput.

Constant Distance Measurements

Study conformational state fluctuations with unparalleled force stability of less than 0.3 pN drift over minutes.

Starting at €140 000 / US $155 000

Unparalleled force stability

Ultra high stability makes it possible to characterize conformational transitions over extremely long periods of time. See below the stable monitoring of spontaneous local conformational transitions occurring within double-stranded DNA during DNA breathing. The histograms show identical features (number, position of states, state population) indicating that the experiment was performed without altering the state transition kinetics.

Top: Force trace recorded over 520 seconds corresponding to a single dsDNA molecule (8.4 kbp) held at a constant distance using optically-trapped polystyrene beads (Ø = 0.8 μm). The trap stiffness was set to 500 pN/µm. Data were recorded at 50 kHz (gray) and decimated to 1000 Hz (red). Bottom: Histograms of the force values collected for the full trace and for values collected during two different fragments of 50 seconds. 

Features

The m-Trap™ offers a variety of unique and enabling features for probing different biological systems with a large dynamic range.

Optical Tweezers

• Dual (2) trap configuration, one trap fixed
• Ultra-sensitive position sensing detector
• Unparalleled range of trap stiffness and low force noise
• Absolute 3D trap positioning

u-Flux™ Microfluidics

• Ultra-stable passive pressure driven microfluidics
• Monolithic laminar flow cell with automated valve switching
• Truly correlative force-fluorescence data acquisition

m-Trap™ Flex

• Access to the system’s optical path for custom hardware integration

Introducing:

Bluelake Software Suite

Designed from the ground up, our brand new software suite Bluelake provides intuitive controls that bring you closer to your experiment and enable the highest experimental throughput. Manipulate your sample directly with simple mouse and joystick movements, and fully automate your measurement with our powerful Python scripting engine.

With a click of a button, you perform complex single-molecule experiments and gather simultaneous force, bright-field, and instrument status data streams. The new timeline feature ensures you can focus on the data that matters, and never lose anything of value.

Bluelake Software suite
The Bluelake interface, providing full control and data visualization spread over two screens

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