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Phase separation Archives - LUMICKS

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Evaluation of protein droplet viscoelasticity with the C-Trap® reveals new material properties

A recent publication in Science describes a new glass-like structural behavior that protein droplets can adopt, regulating their biochemical behavior as they age. Specifically, through rheological measurements using the C-Trap® optical tweezers, the researchers discovered material properties that may help cells respond to a dynamic molecular environment. The findings offer essential insights into the…
Santiago Gisler
16 February 2021
New C-Trap™ Installed at the University at BuffaloUncategorised

Study establishes molecular forces responsible for condensation of ribonucleoprotein-RNA complexes

Researchers investigated the molecular driving forces underlying the condensation and decondensation of ribonucleoproteins using the C-Trap™. Specifically, they showed that sequence-dependent features of the RNA and ribonucleoprotein molecules partially dictate phase transitions. These findings can help scientists further understand the properties underlying eukaryotic liquid-liquid phase separation, or formation of membrane-less…
Santiago Gisler
5 September 2019

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