Blog posts

C-Trap® experiments suggest tubulin lattice state dictates tau envelope formation

Tau is an intrinsically disordered microtubule-associated protein (MAP) that helps stabilize microtubules by forming an envelope around them. This stabilizing protein has been implicated in neurodegenerative diseases such as Alzheimer’s, where abnormal chemical changes promote detachment of tau from microtubules and the formation of long threads that eventually lead to…
Rozina Kardakaris
22 September 2022
Blog posts

LUMICKS’ C-Trap® adopted by two labs at UBC

We are delighted to announce the installation of two C-Trap® instruments at the University of British Columbia (UBC), Vancouver, Canada, in the labs of Dr. Derek Dee and Dr. Nada Lallous. Derek Dee, Assistant Professor in the Department of Land and Food Systems, focuses his research on the forces that…
Rozina Kardakaris
14 July 2022
Blog posts

New C-Trap® installation at Radboud University to offer insights into chromatin organization

We are thrilled to announce the installation of a C-Trap® at the RIMLS-Science institute, Radboud University, The Netherlands, in the lab of Dr. Jorine Eeftens. The installed C-Trap combines dual-trap optical tweezers with super-resolution confocal microscopy, which will allow the team to perform and visualize single-molecule experiments with unprecedented detail to…
Rozina Kardakaris
14 April 2022
Blog posts

Exploring biomolecular condensate dynamics with the C-Trap® reveals viscoelastic fluid behavior

In a recent article published in Nature Communications by the group of Huan-Xiang Zhou from the University of Illinois, Dr. Archishman Ghosh and co-workers provided insights into the dynamics of biomolecular condensates. Using LUMICKS’ C-Trap® with a dual-trap optical tweezer configuration they obtained direct evidence showing that phase-separated biopolymer condensates…
Rozina Kardakaris
31 March 2022
iScience_monocyte mechanics_Alireza-Mashaghi_optical tweezers_acoustic force spectroscopyBlog posts

Probing monocyte forces with the C-Trap® and acoustic force spectroscopy reveals CCL2 regulation of monocyte mechanics

In a first-of-its-kind study from Leiden University, Evers et al. have provided insights into the mechanical properties of monocytes – cells crucial in the fight against infection. By combining two of LUMICKS’ single-cell force spectroscopy approaches, C-Trap® optical tweezers and acoustic force spectroscopy (AFS), they were able to determine that…
Rozina Kardakaris
16 February 2022

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