Confocal Archives - LUMICKS


Insights into the mechanism of Cas12a dynamics using C-Trap®

A recent publication by Losito et al. from the lab of Prof. David Rueda (Imperial College London), reveals new information on the kinetics and mechanism of Cas12a-DNA interaction. Using the C-Trap® the authors could observe in real-time Cas12a binding, target-search, and DNA cleavage under different conditions and hence expand the…
Nelli Bossert
13 October 2021

Highly reproducible single-molecule analysis of transient structures of native proteins using m-Trap® dual optical tweezers combined with Raman spectroscopy

A recent publication by Dai et al. in Nature Communications presents an optical tweezers-coupled Raman spectroscopy platform providing tuneable and reproducible surface-enhanced Raman spectroscopy (SERS) measurements. By combining a Raman microscope with the dual-trap optical tweezers and microfluidic flow chamber of the m-Trap®, the scientists were able to characterize three…
Nelli Bossert
8 April 2021
ROS activation in macrophages optical tweezers fluorescence microscopyNews

Early activation of single macrophages captured by the C-Trap®

In a recent article published in Small Methods, researchers reveal a method that uniquely captures the early phase of oxidative stress response in macrophages. Employing the powerful combination of optical tweezers, confocal fluorescent microscopy, and microfluidics of the C-Trap®, they measured the real-time intracellular response of individual macrophages to a…
Nelli Bossert
11 March 2021

Study shows how chaperone enzyme ClpB processively translocates polypeptide loops using C-Trap® correlated optical tweezers and confocal microscopy

A new study published in Nature reports how researchers verified the intricate process of disaggregating entangled proteins by analyzing chaperone enzyme ClpB at a single-molecule level. The C-Trap® correlated optical tweezers and confocal microscopy enabled them to analyze how the member of the Hsp100 chaperone family translocates looped polypeptide substrates…
Santiago Gisler
13 February 2020

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