Researchers used C-Trap™ to measure energy landscapes and isomer stability in DNA origami

Researchers used C-Trap™ optical tweezers to study the energy landscapes associated with the formation of specific DNA origami structures, which is the folding of single-stranded DNA into pre-designed configurations. We congratulate all the authors involved in the study “Sites of … Read More

Two papers give new insights on protein droplets using LUMICKS’ C-Trap™

Two new papers published at Physical Review Letters and Nature Communications give new insights on protein droplets. Congratulations to all the authors! Jawerth et al. developed a method to investigate the frequency-dependent rheology and surface tension of protein droplets. They … Read More

New insights into Cas9 off-target activity

The paper “DNA stretching induces Cas9 off-target binding and cleavage” was just published in Nature Structural and Molecular Biology. Congratulations to all the authors! In this paper, scientists at the MRC London Institute of Medical Sciences and AstraZeneca studied how … Read More

New insights on the formation and dynamics of membraneless organelles using C-Trap™

Congratulations to Dr. Priya R. Banerjee and his research group at University at Buffalo, who just published their paper in Biomolecules! In the paper titled “Molecular crowding tunes material states of ribonucleoprotein condensates” they investigated how entropic forces contribute to … Read More

z-Movi cell-ligand application

Unraveling the Kinetics and Strength of T Cell Adhesion to Fibronecting using z-Movi™

A new study in Cell Reports shows the first results obtained using z-Movi™ ! Kamsma et al. used the z-Movi to measure the adhesion forces and kinetics of CD4+ T lymphocytes (CD4) to fibronectin in living conditions. They then investigated how these properties are influenced by … Continue Reading

Measure Cell Mechanics with Acoustic Force Spectroscopy

Novel Method for Single-Cell Mechanical Probing using LUMICKS’ AFS™ System

The article ‘Probing cellular mechanics with Acoustic Force Spectroscopy’ has recently been published in the journal Molecular Biology of the Cell. Congratulations to all the authors on their inspiring research! Undergoing deformations plays a vital role in the function of Red … Continue Reading

Protein Filaments

Novel Insights on the Mechanical Properties of IFs using LUMICKS’ Technology

The journal Science Advances has recently published the paper ‘Viscoelastic properties of vimentin originate from nonequilibrium conformational changes’. We would like to congratulate Prof. Dr. Sarah Köster and all co-authors for their great work on intermediate filaments (IFs)! IFs are … Continue Reading

Intercalated DNA

Method to Quantify Local Force Distribution within Biomolecular Systems

The journal Nano Letters has recently published the article “Quantifying Local Molecular Tension Using Intercalated DNA Fluorescence”. We would like to congratulate all the authors! By using optical tweezers coupled with fluorescence microscopy, Dr. King et al. (2018) studied the … Continue Reading

optical tweezers dna repair force extension manipulation visualization RAD51 Recombination

Investigation of the Interaction of RAD51 with ssDNA Using CTFM and X-ray Crystallography

Recently, the paper “Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA” has been published in The EMBO Journal. Congratulations to Dr. Ineke Brouwer and all co-authors! Brouwer et al. combined Correlative Optical Tweezers-Fluorescence Microscopy (CTFM) … Continue Reading

strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cell

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper “Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase”. We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine … Continue Reading