z-Movi cell-ligand application

Unraveling the Kinetics and Strength of T Cell Adhesion to Fibronecting using z-Movi™

A new study in Cell Reports shows the first results obtained using z-Movi™ ! Kamsma et al. used the z-Movi to measure the adhesion forces and kinetics of CD4+ T lymphocytes (CD4) to fibronectin in living conditions. They then investigated how these properties are influenced by … Continue Reading

Measure Cell Mechanics with Acoustic Force Spectroscopy

Novel Method for Single-Cell Mechanical Probing using LUMICKS’ AFS™ System

The article ‘Probing cellular mechanics with Acoustic Force Spectroscopy’ has recently been published in the journal Molecular Biology of the Cell. Congratulations to all the authors on their inspiring research! Undergoing deformations plays a vital role in the function of Red … Continue Reading

Protein Filaments

Novel Insights on the Mechanical Properties of IFs using LUMICKS’ Technology

The journal Science Advances has recently published the paper ‘Viscoelastic properties of vimentin originate from nonequilibrium conformational changes’. We would like to congratulate Prof. Dr. Sarah Köster and all co-authors for their great work on intermediate filaments (IFs)! IFs are … Continue Reading

Intercalated DNA

Method to Quantify Local Force Distribution within Biomolecular Systems

The journal Nano Letters has recently published the article “Quantifying Local Molecular Tension Using Intercalated DNA Fluorescence”. We would like to congratulate all the authors! By using optical tweezers coupled with fluorescence microscopy, Dr. King et al. (2018) studied the … Continue Reading

optical tweezers dna repair force extension manipulation visualization RAD51 Recombination

Investigation of the Interaction of RAD51 with ssDNA Using CTFM and X-ray Crystallography

Recently, the paper “Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA” has been published in The EMBO Journal. Congratulations to Dr. Ineke Brouwer and all co-authors! Brouwer et al. combined Correlative Optical Tweezers-Fluorescence Microscopy (CTFM) … Continue Reading

strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cell

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper “Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase”. We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine … Continue Reading

acoustic-force-spectroscopy-cell-mechanobiology-2

Investigation of the Integration of AFS™ with Digital Holography Imaging

The research article “Digital holography as 3D tracking tool for assessing acoustophoretic particle manipulation” has recently been published in Optics Express Journal. Congratulations to all the authors! By making use of the AFS™ chip, Cacace et al. (2017) investigated the integration of digital holography (DH) imaging … Continue Reading

C-Trap Chemical Reviews AFS Biochemical Society Transactions

C-Trap™ and AFS™ systems mentioned in two review articles

We are proud to announce that two review articles refer to LUMICKS; one highlighting the C-Trap™ Optical Tweezers-Fluorescence Microscopy system and the other one specifying the AFS™ Acoustic Force Spectroscopy system.  Norregaard et al. (2017) reviews relevant theoretical tools to analyze data obtained from single-molecule … Continue Reading

optical tweezers dna repair force extension manipulation visualization RAD51 Recombination

Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics

The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers … Continue Reading

Q-trap-optical-tweezers-single-molecule-visualization-dna-organization-gif

Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to … Continue Reading