New mechanism of helicase-induced DNA unwinding from nicks found with the C-Trap

A study published in eLife shows how replication protein A (RPA) activates helicase Bloom syndrome protein (BLM) to unwind double-stranded DNA (dsDNA) bidirectionally from nicks. The C-Trap® enabled the researchers to simultaneously measure and visualize the DNA–protein interactions in real … Continue Reading

Controlled ligand gradient through C-Trap facilitates DSM measurements

A publication in the journal Micromachines describes how researchers managed to control the concentrations of DNA-binding dyes in single-molecule optical tweezers experiments on DNA. They established a controlled concentration gradient with the multi-channel laminar microfluidics system integrated with their C-Trap® … Continue Reading

Impressions from LUMICKS’ Training Session for new users

As part of our commitment to support scientists through all the stages towards their first publication using our instruments, we often organize dedicated training sessions. In the case of the lab of Prof. Shi at Tsinghua University, this was in … Read More

Study shows detailed properties of Ca2+ sensors during membrane fusion

A recent study in the Biophysical Journal shows how a Dutch research group measured and visualized dynamic interactions between membranes in the presence of Ca2+ sensors and synaptic inducers Syt1 and Doc2b. With the combined optical tweezers and confocal fluorescence … Continue Reading

A new DNA–protein coupling procedure improves stability for DSM analyses

A recent study in Communications Chemistry shows how a research lab at AMOLF in the Netherlands optimized DNA–protein coupling to study dynamic processes requiring high forces and long-term assessments. Using their C-Trap® Optical Tweezers – Fluorescence Microscopy system, the team … Continue Reading

Study shows how chaperone enzyme ClpB processively translocates polypeptide loops using C-Trap correlated optical tweezers and confocal microscopy

A new study published in Nature reports how researchers verified the intricate process of disaggregating entangled proteins by analyzing chaperone enzyme ClpB at a single-molecule level. The C-Trap® correlated optical tweezers and confocal microscopy enabled them to analyze how the … Continue Reading

C-Trap® installed at Technical University of Munich

We are happy to announce the recent installation of the C-Trap® at the Technical University of Munich, Germany, in the lab of Prof. Matthias Rief. The installed C-Trap combines optical tweezers with 2-color fluorescence microscopy and will be used by … Read More

Dynamic Single-Molecule Workshops in North and South of China

Last week we organized two dynamic single-molecule workshops in the North and South of China – one at Tsinghua University in Beijing, and another at  Sun Yat-sen University (SYSU). Both workshops included in-depth lectures exploring different state-of-the-art single-molecule applications and hands-on demonstrations … Read More

C-Trap™ installed at Tel Aviv University

  We are happy to announce the recent installation of the C-Trap™ at Tel Aviv University, Israel, in the lab of Dr. Raya Sorkin. The C-Trap combines optical tweezers with confocal microscopy and is now available to students and postdocs … Continue Reading

Single-molecule study assesses how cohesin complexes bridge DNA molecules using C-Trap correlated optical tweezers with fluorescence microscopy

In a new study published in the journal Science Advances, Gutierrez-Escribano et al. studied the role of cohesin complexes in DNA tethering to gain a better understanding of sister chromatid cohesion. Using the C-Trap correlated optical tweezers with fluorescence microscopy, they … Read More