Coordinated stimulation of RAD51 filament assembly and growth revealed with the C-Trap®

A recent study published in Molecular Cell used dynamic single-molecule analysis to evaluate the roles of specific proteins involved in the initiating steps of homologous recombination, including nucleation and growth of RAD51 filaments. Specifically, the researchers used the C-Trap® optical … Continue Reading

Distal bridging between nucleosomes by polycomb complex PRC2 identified with the C-Trap®

A recent study published in PNAS used single-molecule force spectroscopy to examine unknown interaction mechanisms between polycomb repressive complex 2 (PRC2) and chromatin. The authors evaluated arrays of multiple nucleosomes using their C-Trap® optical tweezers system and identified distal nucleosome … Continue Reading

C-Trap® installed at Emory University in Atlanta

We are happy to announce the installation of a new C-Trap® system with correlated optical tweezers and three-color confocal imaging functionality at Emory University in Atlanta, Georgia. The installed instrument, which is managed by the research group of Prof. Laura … Read More

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Force-dependent actin filament-binding by α-catenin recorded with the C-Trap®

A recent publication in the journal eLife describes a multidisciplinary study evaluating how the mechanical properties of actin filaments regulate the binding of associated proteins. Specifically, the researchers used the C-Trap® to demonstrate how applied forces on actin filaments enhance … Continue Reading

Madrid

C-Trap® installed at the National Center for Biotechnology in Madrid

We are happy to announce the installation of a C-Trap® Optical Tweezers – Fluorescence and Label-free Microscopy system at the National Center for Biotechnology (CNB), Madrid, managed by the lab of Dr. Fernando Moreno-Herrero. The team will use the C-Trap … Continue Reading

New application note shows how to study transient conformational changes of kinases using the C-Trap®

We are excited to announce that our latest application note, Real-time detection of kinase conformational changes in the presence of a small-molecule inhibitor, is available to download. The application note is perfect for protein research, as it showcases how you … Continue Reading

Researchers use the m-Trap® and C-Trap® to discover CRISPR-Cas9 properties that can help improve in vivo efficiency

A recent publication from the research lab of Dr. Bo Sun presents new findings in the field of gene editing that may help improve in vivo delivery of CRISPR-Cas9 complexes. The team investigated the DNA-binding properties of Staphylococcus aureus Cas9 … Continue Reading

Researchers investigate the effects of biomolecular droplet structure on fusion times using the C-Trap®

In a recent publication, researchers at the University of Illinois at Chicago used the C-Trap® to study the relationship between structural properties of biomolecular condensates and their fusion times. They found that fusion times, an indicator of condensate density, varies … Continue Reading

Electrostatic effects on vimentin stiffness demonstrated with the C-Trap®

A recently published study from the lab of Prof. Sarah Köster at the University of Göttingen investigated how electrostatic conditions influence the mechanical properties of intermediate filament vimentin, such as structural stability. The researchers assessed these features by stretching the … Continue Reading

In vitro characterization of nucleosomes upon DNA unwrapping using the C-Trap®

A recent publication in the journal Scientific Reports describes a new method to create arrays of nucleosome positioning motifs. Through sequential Gibson Assembly reactions, the researchers managed to clone a series of sequence motifs, with high affinity for histone octamers, … Continue Reading