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Testimonials

Dive into the details
Testimonials

Be it big or small. Great relationships with our customers and collaborators, resulting in outstanding science, is our ultimate goal.

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Dynamic single-molecule customer testimonials

Cell avidity customer testimonials

Case studies and testimonials

Dynamic single-molecule research and the power of the C-Trap and m-Trap instruments

  • Senior vice-president at Artios Pharma Ltd and senior group leader at the Francis Crick Institute in London.

    An expert in DNA repair and the treatment of cancer resulting from DNA damage.

    “I think applications like [single-molecule approaches] will become more mainstream in terms of understanding DNA transaction-based reactions and how small molecules interfere with that.”

  • Group leader at the University of British Columbia.

    An expert in biophysical chemistry, biomaterials, single-molecule studies, and polymer chemistry.

    “We use single-molecule force spectroscopy with optical tweezers, these two complementary techniques allow us to explore forces from a few piconewtons to a few hundred piconewtons.”

  • Group leader at Vrije Universiteit Amsterdam.

    An expert in the physics of life processes.

    “The combination of fluorescence with optical tweezers is one of the biggest steps [forward], it allows studying the most complex interactions between protein and DNA.”

  • Group leader at TU Delft.

    An expert in multidisciplinary approaches to study the mechanics and dynamics of cells and tissues.

    “We use [single-molecule techniques] to look at mechanical properties at the molecular level, which we correlate to mechanics at the cellular level.”

  • Distinguished Professor of Microbiology and Molecular Genetics at the University of California at Davis.

    An expert in biochemistry and the molecular biology of DNA repair and homologous recombination.

    “The optical tweezers enable easy manipulation of single-DNA molecules [and] single-protein complexes on those DNA molecules.”

  • Research Director and Group Leader at the Protein Structure and Function program at Novo Nordisk Foundation Center for Protein Research (CPR) at the University of Copenhagen.

    An expert in structural molecular biology, particularly in proteins.

    “Using single-molecule [techniques], you can see the different conformations of molecules, the complementation of these techniques can help us to understand these intermediated states, which is essential to understanding the protein complexes.”

  • Chair of the Physics Department and Group Leader of the Williams lab at Northeastern University.

    An expert in single-molecule biophysics, specializing in the development of single-molecule methods for quantitatively probing the biophysical properties of DNA and RNA.

    “Forces allow you to provide a perturbation to the system to get it to do things it does only rarely and understand the whole energy landscape of the interaction you’re trying to study [as well as] how that extrapolates back to zero force.”

  • Group leader and Professor of Physics of Living Systems at Vrije Universiteit Amsterdam.

    An expert in protein structural dynamics, with a focus in single-molecule biophysics.

    “I think that single-molecule has really [taught] us how molecular machines work, that has been the biggest breakthrough.”

What they've said about us

Customer and collaboration insights from the best in the field.

“With the help of LUMICKS, my student started using this equipment after about 30 minutes of training [and] was quickly able to generate lots of data from it. I feel like this is going to be a very exciting tool in my lab that can help us to answer many important questions we have.”

Prof. Hang ShiPrincipal Scientist at the School of Life Sciences at Tsinghua University

“We will be able to use microfluidics to study function-related dynamics of a single molecule under different experimental conditions. Combined with the power of having a simultaneous mechanical and fluorescent readout, we will be able to uncover previously unexplored details of the conformational cycles of our model proteins.”

Dr. Katarzyna TychPrincipal investigator at the University of Groningen

“We use the C-Trap to directly measure the multidimensional effects of mechanical forces in protein (un)folding, enabled by the combination of single-molecule fluorescence with optical tweezers. These findings provide insights into the mechanisms by which chaperones act to control protein conformations and folding to the native state.”

Prof. Sander TansGroup Leader at the FOM Institute AMOLF

“With such quantitative measurements, we hope to contribute to the understanding of biological processes in which membrane remodeling plays a central role.”

Dr. Raya SorkinSenior Lecturer at Tel Aviv University

“The user-friendly software combined with the high throughput experimental workflow and the dedicated training we received from LUMICKS, has fully equipped us to perform state-of-the-art single-molecule force spectroscopy experiments in no time.”

Prof. Ben SchularProfessor of Molecular Biophysics, University of Zurich

“With the C-Trap, our group can expand our capabilities to investigate nucleic acid mechanics and DNA-protein interactions in novel ways, [we] can now locate fluorescently-labeled proteins on DNA substrates and follow their dynamics in real-time.”

Prof. Fernando Moreno-HerreroPrincipal Investigator at the Centro Nacional de Biotecnología

“The m-Trap and Bluelake software have allowed my lab to get started immediately on experiments due to a user-friendly interface and technical support from LUMICKS. We are excited to use this technology to decipher how the nucleus senses and uses mechanical force.”

Dr. Adrian OlivaresAssistant Professor at Vanderbilt University

“The correlation of force traces with fluorescence observation provides very powerful insights for our research. The team has been fighting over system time!”

Prof. Stephen GrillDirector and Research Group Leader at the MPI-CBG

“Through Harbor, I can help the community with ready-to-go scripts, while getting credit for the work I've done through extra citations.”

John WattersGraduate Fellow at the lab of Shixin Liu, Rockefeller University

“By allowing us to manipulate the topology of DNA molecules while simultaneously imaging the DNA and DNA binding proteins with high spatial and temporal resolution, the C-Trap will open up exciting new avenues of research in the Neuman lab.”

Dr. Kier NeumanGroup Leader at the NIH - National Heart, Lung, and Blood Institute

“C-Trap is a unique and powerful tool that helped us unravel precise molecular mechanisms on how cohesin tethers chromatids. By using the shared instrument located at the Imperial College London together with our collaborators, we were able to perform valuable measurements and build the data presented in our publication* in a few weeks of measurements.”

Prof. Luis AragónProfessor at the London Institute of Medical Sciences

“We believe that the great force resolution and time stability of the m-Trap will be precious assets for us to depict crucial information about the mechanics and work processes of biological and artificial molecular machines", stated Dr. Damien Sluysmans, a researcher in the Duwez group.”

Prof. Anne-Sophie DuwezProfessor and group leader at the University of Liege

“The new system will bring more collaborators and new research ideas from different life science groups, who are interested in optical and single-molecule biomanipulation. Having the C-Trap together with optical expertise in the group will serve the local research environment with state-of-the-art equipment and highly trained experts.”

Prof. Poul Martin BendixProfessor at the University of Copenhagen

“We are extremely pleased to have received the generous support of the BBSRC (grant ref.MR/S021248/1) that enabled us to provide the University of Cambridge with a state-of-the-art single-molecule instrument that was not previously available to the Cambridge community of researchers. We are looking forward to the many novel insights that the C-trap will provide.”

Prof. Lucas PellegriniProfessor at the University of Cambridge, Department of Biochemistry

“The combination of force and single-molecule fluorescence, in an easy-to-use system will accelerate experiments that take days to just take minutes. Making complex tools easier to use, will make ours and the scientific community’s science move faster.”

Dr. Neil KadReader in Molecular Biophysics at the University of Kent

“Just as impressive as the craftsmanship of the instrument is the professional and timely customer support that LUMICKS has provided us on a regular basis over the past years. The relationship between the LUMICKS team and my team is more of a collaborative nature, which is unique and what I find most enjoyable.”

Dr. Shixin LiuAssistant Professor at Rockefeller University and head of the Laboratory of Nanoscale Biophysics and Biochemistry

Case studies and testimonials

Cell avidity research and the power of the z-Movi instrument

  • Associate professor of Medicine University of Barcelona.

    “Using this technology of the z-Movi Cell Avidity Analyzer, we can identify the results that we could be able to see in vivo, which could not be predicted with other strategies in vitro.”

    Click here to view our case study!

  • CSO at Leucid Bio.

    “The z-Movi® system has enabled us to rapidly rank CAR T-cells containing distinct targeting moieties in terms of their avidity for target cells. Since this relies on CAR T-cell to target cell interaction rather than more artificial alternatives, it allows us to pick the “Goldilocks binders” that achieve superior performance.”

    Click here to view our case study!

  • Group Leader of Hematology Department at Amsterdam UMC Cancer Center Amsterdam.

    “The z-Movi® provided an essential piece of evidence in our investigations, giving us critical insight into how these engineered cells work and what is ultimately responsible for their changes in behavior with this new dual-targeting strategy. Understanding the mechanism of action is fundamentally important for any effective drug development study.”

    Click here to view our case study!

     

  • CSO of INmune Bio & Professor of Cell Gene and Tissue Therapy at University College London.

    “We know that CARs that are highly affine are not necessarily as functional as CARs with less affinity. So how does that translate into a CAR-T cell or a CAR-NK cell where it’s not just the interaction of the car with its ligand, but it’s all the other ligands in that synapse that matter? And so I think that cell avidity measurements are going to be extremely important.”

    Click here to view our case study!

What they've said about us

Customer and collaboration insights from the best in the field.

“The z-Movi is the first high throughput tool I have seen to reliably measure cell:cell avidity, allowing us to dissect the temporal nature of the formation of NK cell:tumor cell synapse as well as the critical components required for synapse stability and NK cell triggering...”

Prof. Mark LowdellCSO at INmune Bio

“We expect to gain greater insight into the mechanism of CAR mediated tumor cell recognition and into the selection of the most potent CAR for clinical application...”

Dr. Hinrich AbkenChair for Genetic Immunotherapy at Regensburg University

“Using this technology of the z-Movi® Cell Avidity Analyzer, we can identify the results that we could be able to see in vivo, which could not be predicted with other strategies in vitro.”

Prof. Carlos Fernandez LarreaUniversity Hospital Barcelona

“The z-Movi® provided an essential piece of evidence in our investigations, giving us critical insight into how these engineered cells work and what is ultimately responsible for their changes in behavior with this new dual-targeting strategy...”

Dr. Maria ThemeliGroup Leader of Hematology Department at Amsterdam UMC Cancer Center Amsterdam

“The z-Movi system has enabled us to rapidly rank CAR T-cells containing distinct targeting moieties in terms of their avidity for target cells. Since this relies on CAR T-cell to target cell interaction rather than more artificial alternatives, it allows us to pick the “Goldilocks binders” that achieve superior performance.”

Prof. John MaherCSO at Leucid Bio