Blog posts

Evaluation of protein droplet viscoelasticity with the C-Trap® reveals new material properties

A recent publication in Science describes a new glass-like structural behavior that protein droplets can adopt, regulating their biochemical behavior as they age. Specifically, through rheological measurements using the C-Trap® optical tweezers, the researchers discovered material properties that may help cells respond to a dynamic molecular environment. The findings offer essential insights into the…
j.yeh
16 February 2021
Blog posts

Coordinated stimulation of RAD51 filament assembly and growth revealed with the C-Trap®

A recent study published in Molecular Cell used dynamic single-molecule analysis to evaluate the roles of specific proteins involved in the initiating steps of homologous recombination, including nucleation and growth of RAD51 filaments. Specifically, the researchers used the C-Trap® optical tweezers with correlated confocal microscopy to evaluate the roles of RAD51 paralogues and BRCA2…
j.yeh
16 February 2021
Blog posts

C-Trap® installed at Emory University in Atlanta

We are happy to announce the installation of a new C-Trap® system with correlated optical tweezers and three-color confocal imaging functionality at Emory University in Atlanta, Georgia. The installed instrument, which is managed by the research group of Prof. Laura Finzi and Dr. David Dunlap, will be used by several…
j.yeh
18 November 2020
Blog posts

Force-dependent actin filament-binding by α-catenin recorded with the C-Trap®

A recent publication in the journal eLife describes a multidisciplinary study evaluating how the mechanical properties of actin filaments regulate the binding of associated proteins. Specifically, the researchers used the C-Trap® to demonstrate how applied forces on actin filaments enhance binding of cell–cell adhesion protein α-catenin, but not its homolog…
j.yeh
15 October 2020
Blog posts

C-Trap® installed at the National Center for Biotechnology in Madrid

We are happy to announce the installation of a C-Trap® Optical Tweezers – Fluorescence and Label-free Microscopy system at the National Center for Biotechnology (CNB), Madrid, managed by the lab of Dr. Fernando Moreno-Herrero. The team will use the C-Trap configured with dual traps and correlated three-color confocal to examine…
j.yeh
12 October 2020
Blog posts

Electrostatic effects on vimentin stiffness demonstrated with the C-Trap®

A recently published study from the lab of Prof. Sarah Köster at the University of Göttingen investigated how electrostatic conditions influence the mechanical properties of intermediate filament vimentin, such as structural stability. The researchers assessed these features by stretching the protein in different buffer conditions, using the C-Trap® with correlated optical…
j.yeh
6 August 2020

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