Publication

Frontiers in Immunology Paper Discloses Promising New Insights into CAR-T Cell Efficacy for Cancer Therapies

Dr. Maher’s powerful research underscores the insights that our revolutionary technology can help researchers around the world discover, and help science better address core challenges in human health, particularly in designing potentially more effective immunotherapies to fight cancer.

j.yeh17 March 2022

C-Trap reveals mechanism of protein-DNA co-condensate formation.

Blog posts

C-Trap^® experiments reveal mechanism of protein-DNA co-condensate formation

In a recent publication in PNAS, researchers from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) shed light on how proteins interact with individual DNA molecules to form co-condensates. Using LUMICKS’ C-Trap®, which combines optical tweezers, confocal microscopy, and…

Chenlu Yu16 March 2022

Blog posts

C-Trap^® experiments reveal how a pioneer transcription factor interacts with DNA to regulate gene expression

Researchers from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, led by Stephan W. Grill, have shed light on the physical nature of the interaction between the pioneer transcription factor Klf4 (Krüppel-like factor 4) and DNA. Using the C-Trap®, which combines optical tweezers, confocal microscopy…

Chenlu Yu23 February 2022

iScience_monocyte mechanics_Alireza-Mashaghi_optical tweezers_acoustic force spectroscopy

Blog posts

Probing monocyte forces with the C-Trap^® and acoustic force spectroscopy reveals CCL2 regulation of monocyte mechanics

In a first-of-its-kind study from Leiden University, Evers et al. have provided insights into the mechanical properties of monocytes – cells crucial in the fight against infection. By combining two of LUMICKS’ single-cell force spectroscopy approaches, C-Trap® optical tweezers and acoustic force spectroscopy (AFS), they were able to determine that…

Chenlu Yu16 February 2022

Press releases

New Nature Paper Relies on LUMICKS’ C-Trap^® Technology to Understand Functionality of Key Protein Involved with Incorrect DNA Repair of Dangerous Lesions Linked to Cancer Predisposition

C-Trap® technology was used in new research designed to understand the function of a key protein involved in DSB) repair. DSB repair is fundamental in maintaining the genome integrity and when compromised can lead to cancer predisposition.

j.yeh15 February 2022

Maria Themeli, Amsterdam AMC, T cell sensitivity and persistence, blood cancers, z-Movi, Cell Avidity analysis

Press releases

New study published in Translational Medicine highlights cell avidity’s power as a functional biomarker for improved CAR-T design in preventing tumor escape

Using cell avidity measurements and traditional immuno-assays, the researchers successfully demonstrated that co-expression of costimulatory receptors along with an FDA approved BCMA and CD19 CAR can improve both durability of potential treatments as well as persistence for common blood cancers.

j.yeh23 January 2022

Blog posts

C-Trap^® experiments contribute to elucidating the role of the helicase HELQ in different mechanisms of DNA repair

A recent paper published in Nature by the group of Dr. Simon Boulton from the Francis Crick Institute enlightens the role played by the helicase HELQ in the context of DNA repair. The researchers took advantage of the combination of microfluidics, optical tweezers, and fluorescence microscopy of the C-Trap® to…

j.yeh23 December 2021

Blog posts

ZAP-S binding prevents the refolding of SARS-CoV-2 RNA, inhibits programmed ribosomal frameshifting

A new Nature Communications article sheds light into the mechanisms that govern programmed ribosomal frameshifting (PRF) in SARS-CoV-2 virus, as demonstrated by C-Trap experiments.

j.yeh13 December 2021

Blog posts

ParB sliding to non-specific DNA regions visualized using C-Trap^®

A recent work published in eLife by Francisco de Asis Balaguer et al. shed light on the interaction of ParB with DNA, the consequent DNA condensation, and the role of cytidine triphosphate (CTP) in this process – at a single-molecule level. Using the C-Trap® the researchers investigated the role of…

j.yeh30 November 2021

Blog posts

Using C-Trap^® to unravel different binding modes of architectural DNA-binding proteins at different ionic conditions and DNA conformation

A recent study by Szu‐Ning Lin et al. for the first time provided direct information on the dynamics of the interaction between HU and DNA and how this interaction is influenced by ionic conditions and DNA conformation.

j.yeh9 November 2021

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Frontiers in Immunology Paper Discloses Promising New Insights into CAR-T Cell Efficacy for Cancer Therapies

C-Trap^® experiments reveal mechanism of protein-DNA co-condensate formation

C-Trap^® experiments reveal how a pioneer transcription factor interacts with DNA to regulate gene expression

Probing monocyte forces with the C-Trap^® and acoustic force spectroscopy reveals CCL2 regulation of monocyte mechanics

New Nature Paper Relies on LUMICKS’ C-Trap^® Technology to Understand Functionality of Key Protein Involved with Incorrect DNA Repair of Dangerous Lesions Linked to Cancer Predisposition

New study published in Translational Medicine highlights cell avidity’s power as a functional biomarker for improved CAR-T design in preventing tumor escape

C-Trap^® experiments contribute to elucidating the role of the helicase HELQ in different mechanisms of DNA repair

ZAP-S binding prevents the refolding of SARS-CoV-2 RNA, inhibits programmed ribosomal frameshifting

ParB sliding to non-specific DNA regions visualized using C-Trap^®

Using C-Trap^® to unravel different binding modes of architectural DNA-binding proteins at different ionic conditions and DNA conformation

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