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Publication Archives - Page 2 of 7 - LUMICKS

News

Evaluation of protein droplet viscoelasticity with the C-Trap® reveals new material properties

A recent publication in Science describes a new glass-like structural behavior that protein droplets can adopt, regulating their biochemical behavior as they age. Specifically, through rheological measurements using the C-Trap® optical tweezers, the researchers discovered material properties that may help cells respond to a dynamic molecular environment. The findings offer essential insights into the…
Santiago Gisler
16 February 2021
News

Coordinated stimulation of RAD51 filament assembly and growth revealed with the C-Trap®

A recent study published in Molecular Cell used dynamic single-molecule analysis to evaluate the roles of specific proteins involved in the initiating steps of homologous recombination, including nucleation and growth of RAD51 filaments. Specifically, the researchers used the C-Trap® optical tweezers with correlated confocal microscopy to evaluate the roles of RAD51 paralogues and BRCA2…
Santiago Gisler
16 February 2021
News

Researchers study the viscoelasticity of human cells as a response to external cues using the high-throughput AFS®

A recent publication in Small introduces you to the value of acoustic force spectroscopy (AFS®) to study the viscoelastic properties of individual cells in high throughput. The authors describe how they used this “plug-and-play” instrument to measure mechanical cell properties upon external cues seamlessly. Romanov et al. specifically assessed how alterations to…
Santiago Gisler
16 February 2021
News

New study highlights interconvertible RecA–ssDNA states with the help of u-Flux™ microfluidics

A recent publication in FEBS Letters describes how the presence of ADP and ATP affects the structural transitions that single-stranded DNA (ssDNA) undergoes upon RecA-filament assembly. The researchers used the u-Flux™ Laminar Flow Microfluidics combined with optical tweezers to demonstrate that the bacterial homologous recombination-enzyme exists in two interconvertible states.…
Santiago Gisler
29 October 2020
News

Electrostatic effects on vimentin stiffness demonstrated with the C-Trap®

A recently published study from the lab of Prof. Sarah Köster at the University of Göttingen investigated how electrostatic conditions influence the mechanical properties of intermediate filament vimentin, such as structural stability. The researchers assessed these features by stretching the protein in different buffer conditions, using the C-Trap® with correlated optical…
Santiago Gisler
6 August 2020

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