Publication

Blog posts

Transcription factors and chromatin co-condensate and generate forces that alter genomic structure and function

Researchers led by Yael David and Shixin Liu have published a Nature Communications study describing for the first time the mechanisms underlying the co-condensation between transcription factors and DNA. By performing dynamic single-molecule experiments using LUMICKS’ C-Trap® technology, they were able to prove the physiological importance of phase-separated sub-compartments (co-condensates)…

Chenlu Yu7 December 2022

Blog posts

Dynamic single-molecule experiments expose catch bonds as key to cell strength and flexibility

In a recent Nature Materials publication, scientists show for the first time how certain types of molecular bonds known as “catch bonds” make it possible for cells to combine both mechanical strength to withstand forces and adaptability to change shape and move. By performing dynamic single-molecule experiments with LUMICKS’ C-Trap®,…

Chenlu Yu13 October 2022

Blog posts

C-Trap^® experiments suggest tubulin lattice state dictates tau envelope formation

Tau is an intrinsically disordered microtubule-associated protein (MAP) that helps stabilize microtubules by forming an envelope around them. This stabilizing protein has been implicated in neurodegenerative diseases such as Alzheimer’s, where abnormal chemical changes promote detachment of tau from microtubules and the formation of long threads that eventually lead to…

Chenlu Yu22 September 2022

Blog posts

m-Trap^® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

Until recently, the understanding of membraneless organelles (MLOs) was hindered by the inability to control their bioactivities in a precise manner. In a recent Nature Communications article from the lab of Huang and Sun, University of Hong Kong, researchers were able to overcome this obstacle by producing synthetic MLOs that…

j.yeh23 August 2022

Blog posts

Dynamic single-molecule analysis reveals non-linear stiffening of mitotic chromosomes

In a recent study performed by Vrije Universiteit Amsterdam and the University of Copenhagen, researchers used LUMICKS’ u-Flux™ laminar flow microfluidics system together with optical tweezers and fluorescence microscopy – features combined in LUMICKS’ C-Trap® – to shed light on the structural organization of mitotic chromosomes. When preparing to undergo…

Chenlu Yu17 June 2022

“Avidity Enhancement” As New Strategy for Improving CAR T Therapy for AML

Press releases

Cancer Cell Paper Identifies “Avidity Enhancement” As New Strategy for Improving CAR T Therapy for Acute Myeloid Leukemia

The study details a novel strategy for better cancer treatment with CAR T cells for AML. "Avidity Enhancement", increasing cell-cell binding from both the tumor and CAR T cell side, led to a more effective eradication of tumors in mouse models of AML.

j.yeh24 May 2022

Blog posts

C-Trap^® studies reveal GroEL-ES protein folding acceleration mechanism

In a recent Science Advances publication, the group of Sander J. Tans from the AMOLF Institute, The Netherlands, demonstrate for the first time, at the single molecule level, how the molecular chaperone GroEL-ES modulates protein chain collapse and stimulates protein folding. Using LUMICKS’ C-Trap®, they were able to follow and visualize…

Chenlu Yu17 May 2022

Press releases

Nature Paper Identifies “Avidity Escape” as Solid Tumor Evasion Mechanism of CAR T Cell Cancer Therapies

In this study led by the team of Dr. Marcela Maus at Harvard Medical School, the LUMICKS z-Movi® Cell Avidity Analyzer showed that loss of interferon-γ receptor (IFNγR) signaling decreased cell binding avidity between CAR T cells and their target solid tumor cells.

j.yeh2 May 2022

Blog posts

Exploring biomolecular condensate dynamics with the C-Trap^® reveals viscoelastic fluid behavior

In a recent article published in Nature Communications by the group of Huan-Xiang Zhou from the University of Illinois, Dr. Archishman Ghosh and co-workers provided insights into the dynamics of biomolecular condensates. Using LUMICKS’ C-Trap® with a dual-trap optical tweezer configuration they obtained direct evidence showing that phase-separated biopolymer condensates…

Chenlu Yu31 March 2022

Gosse Adema Professor, Radboud University Medical Centre Nijmegen

Press releases

New Study Highlights Cell Avidity’s Power to Provide Insights into the Robustness of T Cell Activation

New study by the team of Professor Gosse Adema demonstrates how cell avidity can be used to assess the effect of lead compounds on immune cells.

j.yeh22 March 2022

Join our newsletter

First Name

Last Name

E-mail address *

Country

Get exclusive news on the latest publications, product developments, events and breakthrough science.

Application of interest *

Dynamic single-molecule analysis

Cell avidity analysis

By submitting the form you agree to LUMICKS' privacy policy. You can revoke your consent at any time.

If you are human, leave this field blank.

Cookie	Duration	Description
Boxzilla	3 days	This cookie remembers if you have already closed a modal to make sure we don't show you the same information twice.
cookielawinfo-checkbox-advertisement	1 year	Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .
cookielawinfo-checkbox-analytics	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
CookieLawInfoConsent	1 year	Records the default button state of the corresponding category & the status of CCPA. It works only in coordination with the primary cookie.
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.

Cookie	Duration	Description
_ga	2 years	The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
_gat_gtag_UA_57399829_1	1 minute	Set by Google to distinguish users.
_gcl_au	3 months	Provided by Google Tag Manager to experiment advertisement efficiency of websites using their services.
_gid	1 day	Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
Clarity		Clarity is a user behavior analytics tool that helps you understand how users are interacting with our website through session replays and heatmaps.
Google Analytics Universal	1 minute	A variation of the _gat cookie set by Google Analytics and Google Tag Manager to allow website owners to track visitor behaviour and measure site performance. The pattern element in the name contains the unique identity number of the account or website it relates to.
pardot	past	The pardot cookie is set while the visitor is logged in as a Pardot user. The cookie indicates an active session and is not used for tracking.
Pardot visitor	1 year	No description
Pardot visitor hashed	1 year	The Pardot cookie to link visitors to prospects

Cookie	Duration	Description
Cience		Tracking performance of Cience ads
Linkedin Insight		The LinkedIn Insight tag helps us keep track of conversions and traffic coming from the LinkedIn platform.
test_cookie	15 minutes	The test_cookie is set by doubleclick.net and is used to determine if the user's browser supports cookies.

Transcription factors and chromatin co-condensate and generate forces that alter genomic structure and function

Dynamic single-molecule experiments expose catch bonds as key to cell strength and flexibility

C-Trap^® experiments suggest tubulin lattice state dictates tau envelope formation

m-Trap^® allows precise control of biological activities in synthetic membraneless organelles (MLOs) in real time

Dynamic single-molecule analysis reveals non-linear stiffening of mitotic chromosomes

Cancer Cell Paper Identifies “Avidity Enhancement” As New Strategy for Improving CAR T Therapy for Acute Myeloid Leukemia

C-Trap^® studies reveal GroEL-ES protein folding acceleration mechanism

Nature Paper Identifies “Avidity Escape” as Solid Tumor Evasion Mechanism of CAR T Cell Cancer Therapies

Exploring biomolecular condensate dynamics with the C-Trap^® reveals viscoelastic fluid behavior

New Study Highlights Cell Avidity’s Power to Provide Insights into the Robustness of T Cell Activation

Recent Posts

Yearly Archive

Applications

Products

About LUMICKS

For pricing, reach out to your application scientist or account manager

Fill in our contact form, we will reach out to you!

Join our newsletter

Download our webinar recording:

Download our Cell Therapy (CAR-T, TCR, NK) applications deck

Publication

Recent Posts

Yearly Archive

Tags

Applications

Products

About LUMICKS

For pricing, reach out to your application scientist or account manager

Fill in our contact form, we will reach out to you!

Join our newsletter

Download our webinar recording:

Download our Cell Therapy (CAR-T, TCR, NK) applications deck

Accept cookies for the best website experience