Chenlu Yu

Dutch Life Science Tools LUMICKS secures €20 million from European Investment Bank to accelerate drug discovery for cancer

Amsterdam-based LUMICKS signs €20 million venture debt with EIB to accelerate the development and launch of its new product, designed to advance immunotherapy development for cancer research. LUMICKS’ next generation high-throughput cell avidity platform aims to transform the drug discovery process by replacing traditional screening methods, expediting development for life-saving…

Chenlu Yu10 October 2024

Blog posts

DNA Polymerase Undergoes Rapid Exchange and Retains Memory at Replication Forks

Explore groundbreaking research on DNA polymerase exchange dynamics using the innovative C-Trap technology. Learn how this study offers new insights into DNA replication, polymerase activity, and the dynamic nature of the replisome. Ideal for both scientists and biotechnology professionals.

Chenlu Yu28 August 2024

Blog posts

Key mechanism in Fanconi Anemia pathway discovered with the C-Trap

Explore groundbreaking research on the FANCD2-I complex, central to the Fanconi anemia pathway, and its newly discovered mechanism in DNA repair and replication fork protection. This deep dive details the latest insights from recent studies, elucidating the complex's role in genomic stability and potential implications for cancer therapy.

Chenlu Yu1 August 2024

Blog posts

Chromatin remodeling dynamics revealed at the single-molecule level in a recent pioneering study

Explore groundbreaking research on chromatin remodeling dynamics using the C-Trap, revealing 'hopping' and 'sliding' mechanisms of chromatin remodelers on DNA. Gain insights into the push-pull model and its implications for gene regulation and genomic integrity. Dive into the latest advancements in genomic research.

Chenlu Yu30 May 2024

Press releases

LUMICKS Appoints Hugo de Wit as CEO and Executive Board Director

Life Sciences Veteran Joins To Accelerate Company Growth Amsterdam, the Netherlands – May 29, 2024 – LUMICKS, a leading life science tools company that develops instruments for dynamic single-molecule and cell avidity analysis, today announced that Hugo de Wit has been appointed Chief Executive Officer, based in the Company’s headquarters…

Chenlu Yu29 May 2024

DNA repair pathwya via PARP1-DNA co-condensation

Blog posts

Securing Broken DNA Ends: PARP1’s Vital Role in Co-Condensation with DNA

Explore how PARP1's involvement in DNA repair through condensate formation secures genetic integrity. Read this blog to understand the dynamics of DNA repair processes in real-time.

Chenlu Yu19 March 2024

Blog posts

Unveiling Key Mechanisms in Kinetochore-Mediated Chromosome Segregation with the C-Trap

Dr. David Barford's study unveils kinetochore dynamics using LUMICKS C-Trap, shedding light on chromosome segregation mechanisms

Chenlu Yu30 January 2024

Blog posts

Towards safe and precise gene therapies: revealing the impact of DNA Supercoiling on CRISPR-Cas9 specificity

CRISPR-Cas9 represents one of the most impactful discoveries in the field of genetic engineering and medicine of recent times. Its discovery catalyzed a paradigm shift in the treatment approach to many genetic diseases, paving the way to simple and effective gene therapy for a large class of diseases. In fact, the…

Chenlu Yu5 December 2023

Blog posts

Cell mechanics with the C-Trap – cellular tension propagation revisited

Surprising insights into the roles of membranes and the actin cytoskeleton in cellular tension propagation – congratulations to all authors for successfully implementing a new and elegant assay with the C-Trap! There was a long-standing dispute in the scientific community about whether the actin cortex facilitates or impedes tension propagation…

Chenlu Yu28 November 2023

Blog posts

The C-Trap uncovers new insights into the mechanisms for ATP-dependent chromatin remodeling

PICH (Plk1-interacting checkpoint helicase) belongs to the SNF2 family of ATP-dependent chromatin remodelers. However, what makes PICH unique is that it lacks a nucleotide-binding domain despite having a great affinity for bare DNA. Because of this molecular structure, it has been hypothesized that the binding of PICH to chromatinized bridges…

Chenlu Yu13 June 2023

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