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Publication Archives - Page 5 of 7 - LUMICKS

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New insights into Cas9 off-target activity

The paper “DNA stretching induces Cas9 off-target binding and cleavage” was just published in Nature Structural and Molecular Biology. Congratulations to all the authors! In this paper, scientists at the MRC London Institute of Medical Sciences and AstraZeneca studied how CRISPR-Cas9 differentiates between on-targets and off-targets. They used the C-Trap®…
New C-Trap™ Installed at the University at BuffaloUncategorised

New insights on the formation and dynamics of membraneless organelles using C-Trap™

Congratulations to Dr. Priya R. Banerjee and his research group at University at Buffalo, who just published their paper in Biomolecules! In the paper titled “Molecular crowding tunes material states of ribonucleoprotein condensates” they investigated how entropic forces contribute to the formation and dynamics of membraneless organelles. Using their C-Trap…
Kassandra Barbetsea
28 February 2019
optical tweezers dna repair force extension manipulation visualization RAD51 RecombinationUncategorised

Investigation of the Interaction of RAD51 with ssDNA Using CTFM and X-ray Crystallography

Recently, the paper “Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA" has been published in The EMBO Journal. Congratulations to Dr. Ineke Brouwer and all co-authors! Brouwer et al. combined Correlative Optical Tweezers-Fluorescence Microscopy (CTFM) with X-ray crystallography to investigate the function of human RAD51…
Jerom Langeveld
20 March 2018
strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cellUncategorised

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper "Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase". We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine leukemia Virus reverse transcriptase (RT). RT catalyzes the formation of an integration-competent double-stranded DNA…
Jerom Langeveld
26 September 2017
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Investigation of the Integration of AFS™ with Digital Holography Imaging

The research article "Digital holography as 3D tracking tool for assessing acoustophoretic particle manipulation" has recently been published in Optics Express Journal. Congratulations to all the authors! By making use of the AFS™ chip, Cacace et al. (2017) investigated the integration of digital holography (DH) imaging in AFS™ devices to enable label-free 3D tracking of multiple…
Jerom Langeveld
24 July 2017

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