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Publication Archives - Page 4 of 7 - LUMICKS

Uncategorised

Study shows how chaperone enzyme ClpB processively translocates polypeptide loops using C-Trap® correlated optical tweezers and confocal microscopy

A new study published in Nature reports how researchers verified the intricate process of disaggregating entangled proteins by analyzing chaperone enzyme ClpB at a single-molecule level. The C-Trap® correlated optical tweezers and confocal microscopy enabled them to analyze how the member of the Hsp100 chaperone family translocates looped polypeptide substrates…
Santiago Gisler
13 February 2020
Uncategorised

Single-molecule study assesses how cohesin complexes bridge DNA molecules using C-Trap® correlated optical tweezers with fluorescence microscopy

In a new study published in the journal Science Advances, Gutierrez-Escribano et al. studied the role of cohesin complexes in DNA tethering to gain a better understanding of sister chromatid cohesion. Using the C-Trap correlated optical tweezers with fluorescence microscopy, they observed in real-time intermolecular (DNA–DNA) and intramolecular cohesin-derived DNA bridge…
Santiago Gisler
5 December 2019
New C-Trap™ Installed at the University at BuffaloUncategorised

Study establishes molecular forces responsible for condensation of ribonucleoprotein-RNA complexes

Researchers investigated the molecular driving forces underlying the condensation and decondensation of ribonucleoproteins using the C-Trap™. Specifically, they showed that sequence-dependent features of the RNA and ribonucleoprotein molecules partially dictate phase transitions. These findings can help scientists further understand the properties underlying eukaryotic liquid-liquid phase separation, or formation of membrane-less…
Santiago Gisler
5 September 2019
AFSUncategorised

New study maps internal and external structures of red blood cell aggregates by combining AFS® and 3D imaging

Researchers used acoustic force spectroscopy (AFS™) in combination with 3D imaging to induce clustering and rotation of red blood cells, enabling them to study the properties of cell aggregates. The new approach, which is based on radiation and stream forces, allows researchers to retrieve 3D reconstructions of biologically relevant conditions…
Santiago Gisler
29 August 2019
Uncategorised

New study evaluates the dynamics behind viral assembly at the single-molecule level using both C-Trap™ and AFS®

Researchers used the C-Trap™ optical tweezers – fluorescence microscopy system and acoustic force spectroscopy (AFS) to study the processes underlying viral assembly. The study evaluated the capsid formation and DNA condensation of virus-like particles (VLPs) at the single-molecule level and in real time. The results serve to expand our understanding…
Santiago Gisler
22 August 2019

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