Publication

Nature Paper Identifies “Avidity Escape” as Solid Tumor Evasion Mechanism of CAR T Cell Cancer Therapies

In this study led by the team of Dr. Marcela Maus at Harvard Medical School, the LUMICKS z-Movi® Cell Avidity Analyzer showed that loss of interferon-γ receptor (IFNγR) signaling decreased cell binding avidity between CAR T cells and their target solid tumor cells.

j.yeh2 May 2022

Blog posts

Exploring biomolecular condensate dynamics with the C-Trap^® reveals viscoelastic fluid behavior

In a recent article published in Nature Communications by the group of Huan-Xiang Zhou from the University of Illinois, Dr. Archishman Ghosh and co-workers provided insights into the dynamics of biomolecular condensates. Using LUMICKS’ C-Trap® with a dual-trap optical tweezer configuration they obtained direct evidence showing that phase-separated biopolymer condensates…

Chenlu Yu31 March 2022

Gosse Adema Professor, Radboud University Medical Centre Nijmegen

Press releases

New Study Highlights Cell Avidity’s Power to Provide Insights into the Robustness of T Cell Activation

New study by the team of Professor Gosse Adema demonstrates how cell avidity can be used to assess the effect of lead compounds on immune cells.

j.yeh22 March 2022

Press releases

Frontiers in Immunology Paper Discloses Promising New Insights into CAR-T Cell Efficacy for Cancer Therapies

Dr. Maher’s powerful research underscores the insights that our revolutionary technology can help researchers around the world discover, and help science better address core challenges in human health, particularly in designing potentially more effective immunotherapies to fight cancer.

j.yeh17 March 2022

C-Trap reveals mechanism of protein-DNA co-condensate formation.

Blog posts

C-Trap^® experiments reveal mechanism of protein-DNA co-condensate formation

In a recent publication in PNAS, researchers from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) shed light on how proteins interact with individual DNA molecules to form co-condensates. Using LUMICKS’ C-Trap®, which combines optical tweezers, confocal microscopy, and…

Chenlu Yu16 March 2022

Blog posts

C-Trap^® experiments reveal how a pioneer transcription factor interacts with DNA to regulate gene expression

Researchers from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, led by Stephan W. Grill, have shed light on the physical nature of the interaction between the pioneer transcription factor Klf4 (Krüppel-like factor 4) and DNA. Using the C-Trap®, which combines optical tweezers, confocal microscopy…

Chenlu Yu23 February 2022

iScience_monocyte mechanics_Alireza-Mashaghi_optical tweezers_acoustic force spectroscopy

Blog posts

Probing monocyte forces with the C-Trap^® and acoustic force spectroscopy reveals CCL2 regulation of monocyte mechanics

In a first-of-its-kind study from Leiden University, Evers et al. have provided insights into the mechanical properties of monocytes – cells crucial in the fight against infection. By combining two of LUMICKS’ single-cell force spectroscopy approaches, C-Trap® optical tweezers and acoustic force spectroscopy (AFS), they were able to determine that…

Chenlu Yu16 February 2022

Press releases

New Nature Paper Relies on LUMICKS’ C-Trap^® Technology to Understand Functionality of Key Protein Involved with Incorrect DNA Repair of Dangerous Lesions Linked to Cancer Predisposition

C-Trap® technology was used in new research designed to understand the function of a key protein involved in DSB) repair. DSB repair is fundamental in maintaining the genome integrity and when compromised can lead to cancer predisposition.

j.yeh15 February 2022

Maria Themeli, Amsterdam AMC, T cell sensitivity and persistence, blood cancers, z-Movi, Cell Avidity analysis

Press releases

New study published in Translational Medicine highlights cell avidity’s power as a functional biomarker for improved CAR-T design in preventing tumor escape

Using cell avidity measurements and traditional immuno-assays, the researchers successfully demonstrated that co-expression of costimulatory receptors along with an FDA approved BCMA and CD19 CAR can improve both durability of potential treatments as well as persistence for common blood cancers.

j.yeh23 January 2022

Blog posts

C-Trap^® experiments contribute to elucidating the role of the helicase HELQ in different mechanisms of DNA repair

A recent paper published in Nature by the group of Dr. Simon Boulton from the Francis Crick Institute enlightens the role played by the helicase HELQ in the context of DNA repair. The researchers took advantage of the combination of microfluidics, optical tweezers, and fluorescence microscopy of the C-Trap® to…

j.yeh23 December 2021

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