Blog posts

Researchers used u-Flux™ and optical tweezers to measure RecBCD activity

In a study performed at the Technion – Israel Institute of Technology, researchers used our  u-Flux™ laminar flow microfluidics system combined with optical tweezers to investigate the activity of the Escherichia coli enzyme RecBCD and its subunits. The paper titled “Synergy between RecBCD subunit is essential for efficient DNA unwinding” appeared…
11 July 2019
Blog posts

Second C-Trap installed at TU Delft

Another exciting installation in the Netherlands! This time we installed the second C-Trap® Optical Tweezers-Fluorescence Microscopy in the Department of Bionanoscience at the TU Delft, a top tier Dutch university. The system was installed in the lab of Prof. Nynke Dekker. The Nynke Dekker Lab studies the cellular process involved…
3 July 2019
Dynamic Single-Molecule Workshop at HQ AmsterdamBlog posts

Dynamic Single-Molecule Workshop at HQ Amsterdam

Last week, LUMICKS organized a successful Dynamic Single-Molecule Workshop at our headquarters in Amsterdam. Throughout the workshop, the participants explored different state-of-the-art single-molecule applications and attended various technology presentations and discussion. Also, Prof. Sander Tans (AMOLF) presented his studies with optical tweezers, analyzing a possible direct or indirect role of chaperone proteins in the folding…
26 June 2019
Blog posts

Two papers give new insights on protein droplets using LUMICKS’ C-Trap™

Two new papers published at Physical Review Letters and Nature Communications give new insights on protein droplets. Congratulations to all the authors! Jawerth et al. developed a method to investigate the frequency-dependent rheology and surface tension of protein droplets. They used the C-Trap™ optical tweezers – fluorescence microscope to trap…
31 May 2019
C-Trap® SR installed at the National Institutes of Health (NIH)Blog posts

C-Trap® SR installed at the National Institutes of Health (NIH)

A new C-Trap® SR was installed at the National Institutes of Health, Maryland, USA, in the labs of Prof. Antonina Roll-Mecak and Prof. Keir Neuman. The LUMICKS optical tweezers-STED nanoscopy system allows the user to visualize molecular interactions with super-resolution microscopy. The highly interdisciplinary group of Prof. Roll-Mecak works on unraveling the chemical and genetic complexity of the microtubule cytoskeleton, or "the tubulin code". The…
Jerom Langeveld
14 May 2019
Single-Molecule Workshop at ShanghaiTechBlog posts

Dynamic Single-Molecule Workshop at the ShanghaiTech University

The first dynamic single-molecule workshop of the year just came to an end! Last week, 16 participants got to experience the C-Trap® Optical Tweezers – Fluorescence Microscope to investigate DNA mechanics and do experiments using their own samples. Additionally, the workshop included lectures from Prof. Bo Sun, during which he discussed his…
26 April 2019
C-Trap® SR installed at Northeastern UniversityBlog posts

C-Trap™ SR installed at Northeastern University

We are happy to have installed a C-Trap® SR, our optical tweezers-STED nanoscope, in shared lab space for an interdisciplinary group led by Prof. Mark Williams at Northeastern University, in Massachusetts, USA. The lab of Prof. Williams is highly regarded as one of the leaders of single-molecule analysis, making us even more proud of this installation. The lab focuses…
16 April 2019
C-Trap installation at Sun Yat-sen University, ChinaBlog posts

C-Trap™ installed at Sun Yat-sen University, China

School of Physics at the Sun Yat-sen University, China, is now equipped with a C-Trap™ Optical Tweezers-Fluorescence Microscope. This advanced instrument is believed to be able to boost up a variety of exciting researches in SYSU, such as DNA/RNA mechanics and protein-DNA or -RNA interactions during DNA replication, transcription, and repair that Prof.…
8 April 2019
C-Trap installation at B CUBE TU DresdenBlog posts

Second C-Trap™ installed in Dresden, Germany

The city of Dresden, Germany, is now the home of two C-Trap® systems! The latest installation took place at the Center for Molecular and Cellular Bioengineering at TU Dresden, where the instrument became part of the Joint Technology Platform. Being operated in the "Molecular Imaging and Manipulation" facility, the system will be available to multiple…
26 March 2019
Blog posts

New insights into Cas9 off-target activity

The paper “DNA stretching induces Cas9 off-target binding and cleavage” was just published in Nature Structural and Molecular Biology. Congratulations to all the authors! In this paper, scientists at the MRC London Institute of Medical Sciences and AstraZeneca studied how CRISPR-Cas9 differentiates between on-targets and off-targets. They used the C-Trap®…
8 March 2019

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