Jawerth et al. developed a method to investigate the frequency-dependent rheology and surface tension of protein droplets. They used the C-Trap™ optical tweezers – fluorescence microscope to trap a protein droplet consisting of PGL-3 condensates and measure its material properties. Their findings show that protein condensates exhibit viscoelastic material properties which can be regulated by tuning the salt concentration.
In the second article, Gui et al. investigated how hnRNPA1 contributes to cellular compartmentation under cellular stress and illuminated the functional role of reversible amyloids in the assembly of stress granules. They combined optical tweezer measurements, using LUMICKS’ C-Trap™, and FRAP measurements to monitor the fusion of wild-type hnRNAP1 droplets and two of their mutants. Their results showed that reversible fibrils affected the fusion of the droplets and reinforced hnRNAP1 phase separation, indicating that reversible fibrils play an essential role in the assembly of stress granules.
The C-Trap™ Optical Tweezers – Fluorescence Microscopy used in these papers is made commercially available by LUMICKS. Are you interested in using the instrument for your own research? Please feel free to contact us for a demo or quote.
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
Set by Google to distinguish users.
Provided by Google Tag Manager to experiment advertisement efficiency of websites using their services.
Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
Clarity is a user behavior analytics tool that helps you understand how users are interacting with our website through session replays and heatmaps.
Google Analytics Universal
A variation of the _gat cookie set by Google Analytics and Google Tag Manager to allow website owners to track visitor behaviour and measure site performance. The pattern element in the name contains the unique identity number of the account or website it relates to.
The pardot cookie is set while the visitor is logged in as a Pardot user. The cookie indicates an active session and is not used for tracking.