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optical tweezers dna repair force extension manipulation visualization RAD51 RecombinationBlog posts

Investigation of the Interaction of RAD51 with ssDNA Using CTFM and X-ray Crystallography

Recently, the paper “Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA" has been published in The EMBO Journal. Congratulations to Dr. Ineke Brouwer and all co-authors! Brouwer et al. combined Correlative Optical Tweezers-Fluorescence Microscopy (CTFM) with X-ray crystallography to investigate the function of human RAD51…
Jerom Langeveld
20 March 2018
strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cellBlog posts

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper "Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase". We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine leukemia Virus reverse transcriptase (RT). RT catalyzes the formation of an integration-competent double-stranded DNA…
Jerom Langeveld
26 September 2017
C-Trap Chemical Reviews AFS Biochemical Society TransactionsBlog posts

C-Trap® and AFS™ systems mentioned in two review articles

We are proud to announce that two review articles refer to LUMICKS; one highlighting the C-Trap® Optical Tweezers-Fluorescence Microscopy system and the other one specifying the AFS™ Acoustic Force Spectroscopy system.  Norregaard et al. (2017) reviews relevant theoretical tools to analyze data obtained from single-molecule experiments performed in intracellular environments and describes state-of-the art visualization techniques…
Jerom Langeveld
6 July 2017
optical tweezers dna repair force extension manipulation visualization RAD51 RecombinationBlog posts

Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics

The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers coupled with fluorescence microscopy and microfluidics were used to investigate…
Jerom Langeveld
24 March 2017
Blog posts

Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to study the mechanism of SYCP3-mediated chromosome organization during meiosis, by…
Jerom Langeveld
16 March 2017
DNA-repair-NatureBlog posts

Paper Using LUMICKS Technology Published in Nature

Great news: Another paper using LUMICKS technology was published, this time in Nature! Congratulations to the authors. Several are now part of LUMICKS. In the study “Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA” Brouwer et al. describe how XRCC4 and XLF proteins play a crucial role…
Jerom Langeveld
21 July 2016
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