Skip to main content

Acinetodin and Klebsidin Lasso Peptides Studied with AFS™ Technology


The first paper from one of our clients using AFS technology has been published in the journal ACS Chemical Biology led by prof. Mikhail Khodorkovskii. Congratulations to all the authors!

In the paper named “Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae” Prof. Khodorkovskii and his group study the bioinformatic prediction and structural validation of two new lasso peptides encoded by several human-associated species of Klebsiella and Acinetobacter: acinetodin and klebsidin. Using the AFS™, they performed kinetic analysis of transcription elongation by E.coli RNA polymerase, showing that these lasso proteins bind to a common site on the Escherichia coli genome, inhibiting transcription as well as transcription elongation by the E. coli RNA polymerase.

Interested in other applications of the LUMICKS AFS™ technology, read more here.

Close Menu

For pricing, reach out to your application scientist or account manager

Open Email

Fill in our contact form, we will reach out to you!

Please include ‘Lakeview data analysis price inquiry’ in the Message box

Contact Us

Join our newsletter

Get exclusive news on the latest publications, product developments, events and breakthrough science.

By submitting the form you agree to LUMICKS' privacy policy. You can revoke your consent at any time.

Download our webinar recording:


Download our Cell Therapy (CAR-T, TCR, NK) applications deck