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Two papers give new insights on protein droplets using LUMICKS’ C-Trap™

Two new papers published at Physical Review Letters and Nature Communications give new insights on protein droplets. Congratulations to all the authors! Jawerth et al. developed a method to investigate the frequency-dependent rheology and surface tension of protein droplets. They used the C-Trap™ optical tweezers – fluorescence microscope to trap…
j.yeh
31 May 2019
Blog posts

New insights into Cas9 off-target activity

The paper “DNA stretching induces Cas9 off-target binding and cleavage” was just published in Nature Structural and Molecular Biology. Congratulations to all the authors! In this paper, scientists at the MRC London Institute of Medical Sciences and AstraZeneca studied how CRISPR-Cas9 differentiates between on-targets and off-targets. They used the C-Trap®…
j.yeh
8 March 2019
optical tweezers dna repair force extension manipulation visualization RAD51 RecombinationBlog posts

Investigation of the Interaction of RAD51 with ssDNA Using CTFM and X-ray Crystallography

Recently, the paper “Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA" has been published in The EMBO Journal. Congratulations to Dr. Ineke Brouwer and all co-authors! Brouwer et al. combined Correlative Optical Tweezers-Fluorescence Microscopy (CTFM) with X-ray crystallography to investigate the function of human RAD51…
Jerom Langeveld
20 March 2018
strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cellBlog posts

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper "Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase". We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine leukemia Virus reverse transcriptase (RT). RT catalyzes the formation of an integration-competent double-stranded DNA…
Jerom Langeveld
26 September 2017
C-Trap Chemical Reviews AFS Biochemical Society TransactionsBlog posts

C-Trap® and AFS™ systems mentioned in two review articles

We are proud to announce that two review articles refer to LUMICKS; one highlighting the C-Trap® Optical Tweezers-Fluorescence Microscopy system and the other one specifying the AFS™ Acoustic Force Spectroscopy system.  Norregaard et al. (2017) reviews relevant theoretical tools to analyze data obtained from single-molecule experiments performed in intracellular environments and describes state-of-the art visualization techniques…
Jerom Langeveld
6 July 2017
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