Skip to main content

Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors!

In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to study the mechanism of SYCP3-mediated chromosome organization during meiosis, by probing how the DNA-binding behavior of the synaptonemal complex protein SYCP3 is affected by DNA compaction. Syrjänen et al. showed that SYCP3 oligomers have two different binding modes to DNA: one diffusive mode where the protein binds to and diffuses along the DNA, and one bridging mode in which a SYCP3 tetramer bridges the sides of a DNA loop. Moreover, the SYCP3-mediated loops are further stabilized by the local aggregation of proteins in large clusters consisting of between 20 and 90 tetramers.

The techniques used in this paper are made commercially available by LUMICKS. Read more about the C-Trap® optical tweezers here.

Close Menu

For pricing, reach out to your application scientist or account manager

Open Email

Fill in our contact form, we will reach out to you!

Please include ‘Lakeview data analysis price inquiry’ in the Message box

Contact Us

Join our newsletter

Get exclusive news on the latest publications, product developments, events and breakthrough science.

By submitting the form you agree to LUMICKS' privacy policy. You can revoke your consent at any time.

Download our webinar recording:


Download our Cell Therapy (CAR-T, TCR, NK) applications deck