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C-Trap

Blog posts

Exploring biomolecular condensate dynamics with the C-Trap® reveals viscoelastic fluid behavior

In a recent article published in Nature Communications by the group of Huan-Xiang Zhou from the University of Illinois, Dr. Archishman Ghosh and co-workers provided insights into the dynamics of biomolecular condensates. Using LUMICKS’ C-Trap® with a dual-trap optical tweezer configuration they obtained direct evidence showing that phase-separated biopolymer condensates…
Chenlu Yu
31 March 2022
C-Trap reveals mechanism of protein-DNA co-condensate formation.Blog posts

C-Trap® experiments reveal mechanism of protein-DNA co-condensate formation

In a recent publication in PNAS, researchers from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) shed light on how proteins interact with individual DNA molecules to form co-condensates. Using LUMICKS’ C-Trap®, which combines optical tweezers, confocal microscopy, and…
Chenlu Yu
16 March 2022
iScience_monocyte mechanics_Alireza-Mashaghi_optical tweezers_acoustic force spectroscopyBlog posts

Probing monocyte forces with the C-Trap® and acoustic force spectroscopy reveals CCL2 regulation of monocyte mechanics

In a first-of-its-kind study from Leiden University, Evers et al. have provided insights into the mechanical properties of monocytes – cells crucial in the fight against infection. By combining two of LUMICKS’ single-cell force spectroscopy approaches, C-Trap® optical tweezers and acoustic force spectroscopy (AFS), they were able to determine that…
Chenlu Yu
16 February 2022
Press releases

LUMICKS Announces the Installation of its Quadruple C-Trap® Instrument at Rockefeller University to Expand Fundamental Research of DNA Processes

The C-Trap will support the research of Prof. Michael O’Donnell to investigate the mechanisms of DNA replication. Between O’Donnell and his collaborator Prof Shixin Liu, Rockefeller University will use the C-Trap to unveil the mechanisms of many types of enzymes, such as multi-protein DNA replicating machines of bacteria and eukaryotes.
j.yeh
11 January 2022
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