j.yeh

Blog posts

New application note shows how to study processes associated with phase separation in real time using the C-Trap^®

We are excited to tell you that our application note Manipulate and Study Protein Droplet Dynamics and Properties in Real Time to Understand Phase Separation is now available to download. Here, you can learn how to unravel the properties, formation, and nature of protein droplets, associated with both healthy and…

j.yeh28 November 2019

Blog posts

Study finds essential Cas9–DNA interaction downstream of PAM using a single-molecule approach

A new publication shows how the lab of Dr. Bo Sun used the m-Trap® to analyze the interactions between a Cas9–gRNA complex and DNA. Using a single-molecule approach to unzip the target double-stranded DNA, the team showed interaction points on the DNA that affected Cas9 binding and cleavage. These results can…

j.yeh21 November 2019

Top banner image was licensed by The University of Vermont / Flickr.

Blog posts

C-Trap^® installed at University of Vermont

We are happy to announce the recent installation of the C-Trap® at the University of Vermont Larner College of Medicine. Several labs will use the correlated optical tweezers – fluorescence microscopy instrument to investigate the dynamics of molecular machines that interact with their tracks to generate force and motion. These processes are…

j.yeh22 October 2019

C-Trap Albert Einstein College of Medicine

Blog posts

C-Trap^® installed at Albert Einstein College of Medicine

We are happy to announce the installation of the C-Trap™ at the Albert Einstein College of Medicine in New York in the lab of Prof. Dr. Arne Gennerich. The instrument combines optical tweezers with 3-color total internal reflection fluorescence (TIRF; a technology that reduces fluorescence background noise in surface-based assays)…

j.yeh1 October 2019

Blog posts

New application note shows how to study Cas9 target specificity at the single-molecule level using the C-Trap^®

We are happy to announce that our application note Analyze Cas9 Binding and Cleavage Properties in Real Time while Manipulating DNA Structures is available to download on our website. In this application note, you can learn how the group of Prof. Dr. David Rueda used the C-Trap™ optical tweezers –…

j.yeh26 September 2019

Press releases

Minister van Engelshoven Inaugurates New LUMICKS Headquarters in Amsterdam

On September 16 we celebrated the grand opening of its new headquarters in Amsterdam. Ingrid van Engelshoven, Dutch minister of Education, Culture and Science (OCW) performed the opening ceremony by cutting a DNA molecule using a laser beam. The new headquarters of LUMICKS are in an old bicycle factory, situated…

j.yeh16 September 2019

New C-Trap® Installed at the University at Buffalo

Blog posts

Study establishes molecular forces responsible for condensation of ribonucleoprotein-RNA complexes

Researchers investigated the molecular driving forces underlying the condensation and decondensation of ribonucleoproteins using the C-Trap™. Specifically, they showed that sequence-dependent features of the RNA and ribonucleoprotein molecules partially dictate phase transitions. These findings can help scientists further understand the properties underlying eukaryotic liquid-liquid phase separation, or formation of membrane-less…

j.yeh5 September 2019

Blog posts

New study maps internal and external structures of red blood cell aggregates by combining AFS® and 3D imaging

Researchers used acoustic force spectroscopy (AFS™) in combination with 3D imaging to induce clustering and rotation of red blood cells, enabling them to study the properties of cell aggregates. The new approach, which is based on radiation and stream forces, allows researchers to retrieve 3D reconstructions of biologically relevant conditions…

j.yeh29 August 2019

Blog posts

New study evaluates the dynamics behind viral assembly at the single-molecule level using both C-Trap™ and AFS®

Researchers used the C-Trap™ optical tweezers – fluorescence microscopy system and acoustic force spectroscopy (AFS) to study the processes underlying viral assembly. The study evaluated the capsid formation and DNA condensation of virus-like particles (VLPs) at the single-molecule level and in real time. The results serve to expand our understanding…

j.yeh22 August 2019

Blog posts

First Dynamic Single-Molecule Summer School in China!

Yet another premiere! LUMICKS organized the very first Dynamic Single-Molecule Summer School at Tsinghua University in Beijing. During the three-day event, nineteen participants received in-depth training in both the theory and practice of dynamic single-molecule (DSM) techniques. Our application scientists dedicated the mornings for lectures on various topics involved in DSM…

j.yeh14 August 2019

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