This application note introduces you to four published experiments that assessed the fundamental processes linked with phase separation. Using the C-Trap® correlated optical tweezers with fluorescence microscopy, the respective research groups could study assembly, fusion, and solidification processes of protein droplets in real time to understand:
Which factors regulate liquid protein droplets and their transitions to solid aggregates.
The relationships between protein droplets and irreversible solid amyloid fibril structures, linked with certain diseases.
How the material properties of protein droplets change during solidification.
The data presented in the application note were featured in the journals Biomolecules (Kaur et al., 2019), Journal of the American Chemical Society (Alshareedah et al., 2019), Physical Review Letters (Jawerth et al., 2018) and Nature Communications (Gui et al., 2019).
We thank all the involved researchers for a fantastic job and collaboration and wish them continued success in their future research.
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
Set by Google to distinguish users.
Provided by Google Tag Manager to experiment advertisement efficiency of websites using their services.
Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
Clarity is a user behavior analytics tool that helps you understand how users are interacting with our website through session replays and heatmaps.
Google Analytics Universal
A variation of the _gat cookie set by Google Analytics and Google Tag Manager to allow website owners to track visitor behaviour and measure site performance. The pattern element in the name contains the unique identity number of the account or website it relates to.
The pardot cookie is set while the visitor is logged in as a Pardot user. The cookie indicates an active session and is not used for tracking.