z-Movi

Blog posts

Measure interaction strength between target cell and TCR T-cell in HPV-related cancers with the z-Movi^®

In a recent review article in Immunology, Fakhr et al. presented the z-Movi® Cell Avidity Analyzer as a solution to characterize T-cell populations by measuring the binding strength between immune and cancer cells using non-invasive acoustic force. Binding events between a T-cell and its target cell determine the initiation of…

Adrià Ferragut26 March 2021

Blog posts

New application note shows how to rapidly assess CAR T-cell strategies for multiple myeloma

We are excited to announce that our latest application note, Rapid assessment of CAR T-cell strategies for multiple myeloma with the z-Movi® Cell Avidity Analyzer, is available to download. In this application note, we highlight cell avidity and in vivo experiments performed in collaboration with the teams of Dr. Eric Smith (Dana-Farber Cancer Institute) and…

j.yeh16 February 2021

Blog posts

Cell avidity is a superior predictor of CAR T-cell efficacy in myeloma than cytotoxicity – first published z-Movi^® results

We are proud to announce the first publication showing results from cell–cell interaction measurements using the z-Movi® Cell Avidity Analyzer! In the study, Fernández de Larrea et al. demonstrate how cell avidity between CAR T cells and target multiple myeloma cell lines correlated with in vivo results. Notably, the cell…

j.yeh29 July 2020

Blog posts

Screening of cancer targeting TCRs with the z-Movi^®

With the quick development of new single-cell analysis technologies it is now possible to identify cancer-targeting T-Cell Receptors (TCRs) in a single experiment. A recent review published in Methods in Enzymology, presented the z-Movi® Cell Avidity Analyzer among the future platforms for the screening of cancer-targeting TCRs. “This technology is…

j.yeh10 April 2020

Blog posts

The Scientist Magazine features z-Movi^®;

We couldn't have put the essence of our z-Movi®; in better words than the author of this article in The Scientist: "Just as music pulls some folks to the dance floor while others remain stuck to their chairs, sound can now be used to pull some cells loose from their substrate while other cells…

j.yeh25 January 2019

Blog posts

z-Movi^® featured in Science

Our latest product, the z-Movi®;, has been featured in the latest issue of the journal Science! The z-Movi uses acoustic force manipulation to query the interaction strengths of cells with their cognate binding partners. It is based on a lab-on-a-chip assay that allows the assessment of thousands of cell-cell and cell-ligand interactions…

j.yeh5 December 2018

Blog posts

Unraveling the Kinetics and Strength of T Cell Adhesion to Fibronecting using z-Movi^®;

A new study in Cell Reports shows the first results obtained using z-Movi; ! Kamsma et al. used the z-Movi to measure the adhesion forces and kinetics of CD4+ T lymphocytes (CD4) to fibronectin in living conditions. They then investigated how these properties are influenced by interleukin-7 (IL-7), the main regulatory cytokine of CD4 cells. The results…

Jerom Langeveld2 October 2018

Blog posts

High-Throughput Label-free Cell Interaction Studies

At the ASCB | EMBO 2017 meeting, we introduced z-Movi®, a new platform for cell interaction studies. This new method enables direct and label-free screening and sorting of thousands of cells based on their interaction with cell or protein targets. z-Movi® is a breakthrough technology for research and development of personalized therapies, including immunotherapy. It is…

Jerom Langeveld5 December 2017

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