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u-Flux™

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New study highlights interconvertible RecA–ssDNA states with the help of u-Flux™ microfluidics

A recent publication in FEBS Letters describes how the presence of ADP and ATP affects the structural transitions that single-stranded DNA (ssDNA) undergoes upon RecA-filament assembly. The researchers used the u-Flux™ Laminar Flow Microfluidics combined with optical tweezers to demonstrate that the bacterial homologous recombination-enzyme exists in two interconvertible states.…
j.yeh
29 October 2020
Blog posts

Researchers used u-Flux™ and optical tweezers to measure RecBCD activity

In a study performed at the Technion – Israel Institute of Technology, researchers used our  u-Flux™ laminar flow microfluidics system combined with optical tweezers to investigate the activity of the Escherichia coli enzyme RecBCD and its subunits. The paper titled “Synergy between RecBCD subunit is essential for efficient DNA unwinding” appeared…
j.yeh
11 July 2019
optical tweezers dna repair force extension manipulation visualization RAD51 RecombinationBlog posts

Investigation of the Interaction of RAD51 with ssDNA Using CTFM and X-ray Crystallography

Recently, the paper “Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA" has been published in The EMBO Journal. Congratulations to Dr. Ineke Brouwer and all co-authors! Brouwer et al. combined Correlative Optical Tweezers-Fluorescence Microscopy (CTFM) with X-ray crystallography to investigate the function of human RAD51…
Jerom Langeveld
20 March 2018
strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cellBlog posts

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper "Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase". We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine leukemia Virus reverse transcriptase (RT). RT catalyzes the formation of an integration-competent double-stranded DNA…
Jerom Langeveld
26 September 2017
Top banner image was licensed by Daniel Schwen / Wikimedia Commons.Blog posts

New C-Trap® acquired by the University of Göttingen

A new C-Trap® system has recently been acquired by the Georg August University in Göttingen, Germany. The C-Trap® was successfully installed in the lab of the “Nanoscale Imaging of Cellular Dynamics” research group, led by Prof. Dr. Sarah Köster, at the Institute for X-Ray Physics. The optical tweezers-fluorescence microscopy system will be…
Jerom Langeveld
7 June 2017
optical-tweezers-fibrin-fibersBlog posts

Effect of Mechanical Stress on Individual Vimentin Filaments Studied using the C-Trap®

The paper "Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain" using LUMICKS’ C-Trap® has recently been published in Physical Review Letters. Congratulations to all the authors! The study led by Prof. Sarah Köster, investigated the mechanical properties of the cytoskeleton in eukaryotic cells; and more specifically…
Jerom Langeveld
27 January 2017
max-planck-institute-molecular-cell-biology-geneticsBlog posts

Customer Case Story MPI-CBG Dresden

In March 2016 LUMICKS delivered a C-Trap® correlative optical tweezers - fluorescence microscopy instrument to the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden. The instrument was acquired at the end of 2015 by a group of MPI-CBG principle investigators to fulfill a need for application…
Jerom Langeveld
15 November 2016
optical-tweezers-fluorescence-microscopy-groningenBlog posts

C-Trap® Installation at University of Groningen

LUMICKS is proud to announce that we successfully installed a C-Trap® at the University of Groningen in the lab of professor Roos. The Roos group will use the optical tweezers-fluorescence microscopy system to investigate the structure and mechanics of viral capsids and their interaction with host cell molecules. We’re looking…
Jerom Langeveld
26 October 2016
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