Explore how PARP1's involvement in DNA repair through condensate formation secures genetic integrity. Read this blog to understand the dynamics of DNA repair processes in real-time.
Chenlu Yu19 March 2024
PICH (Plk1-interacting checkpoint helicase) belongs to the SNF2 family of ATP-dependent chromatin remodelers. However, what makes PICH unique is that it lacks a nucleotide-binding domain despite having a great affinity for bare DNA. Because of this molecular structure, it has been hypothesized that the binding of PICH to chromatinized bridges…
Chenlu Yu13 June 2023
A recent study published in Nature Communications led by Shixin Liu from The Rockefeller University, New York, demonstrates how the C-Trap® can be used to directly visualize and observe molecular mechanisms in action, leading to better and faster insights into critical molecular processes. This study marks an important milestone for LUMICKS,…
Chenlu Yu28 March 2023
For a long time, scientists have been striving to understand how DNA-binding proteins interact with DNA substrates in real time at the single-molecule level, using a variety of imaging techniques and optical platforms. However, for most of these methods scientists always had to choose between studying purified proteins under specific…
Chenlu Yu28 February 2023
C-Trap® experiments highlight the potential of POLQ inhibitors as BRCA-deficient cancer therapeutics
Double-stranded breaks (DSBs) are among the most serious and lethal types of DNA damage known that can lead to cell death and cancer. POLQ is an enzyme in humans that we know plays a crucial role in DSB repair and is overexpressed in many types of cancer, promoting cancer cell…
Chenlu Yu6 February 2023
C-Trap® technology was used in new research designed to understand the function of a key protein involved in DSB) repair. DSB repair is fundamental in maintaining the genome integrity and when compromised can lead to cancer predisposition.
j.yeh15 February 2022
A recent paper published in Nature by the group of Dr. Simon Boulton from the Francis Crick Institute enlightens the role played by the helicase HELQ in the context of DNA repair. The researchers took advantage of the combination of microfluidics, optical tweezers, and fluorescence microscopy of the C-Trap® to…
j.yeh23 December 2021
As turbulent 2020 was, we are happy to have managed to install various LUMICKS instruments all around the world. Our dynamic single-molecule instruments enable researchers to analyze complex dynamic details related to the behavior and interaction of single molecules. One of these installations is the newly installed C-Trap® system at the…
j.yeh23 February 2021
A recent study published in Molecular Cell used dynamic single-molecule analysis to evaluate the roles of specific proteins involved in the initiating steps of homologous recombination, including nucleation and growth of RAD51 filaments. Specifically, the researchers used the C-Trap® optical tweezers with correlated confocal microscopy to evaluate the roles of RAD51 paralogues and BRCA2…
j.yeh16 February 2021
We are happy to announce the installation of a C-Trap® Optical Tweezers – Fluorescence and Label-free Microscopy system at the National Center for Biotechnology (CNB), Madrid, managed by the lab of Dr. Fernando Moreno-Herrero. The team will use the C-Trap configured with dual traps and correlated three-color confocal to examine…
j.yeh12 October 2020
