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C-Trap

Multicolor detection of DNA overstretchingBlog posts

Multicolor Detection Application Note Now Online

Single-molecule force spectroscopy (SMFS) tools are widely used to study structural transitions of DNA during overstretching. However, as many of these tools only provide global information, the exact mechanisms that occur during these transitions remain unclear. Combining SMFS with visualization of local information could resolve this problem. Our Multicolor Detection application…
Jerom Langeveld
30 March 2017
optical tweezers dna repair force extension manipulation visualization RAD51 RecombinationBlog posts

Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics

The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers coupled with fluorescence microscopy and microfluidics were used to investigate…
Jerom Langeveld
24 March 2017
Blog posts

Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to study the mechanism of SYCP3-mediated chromosome organization during meiosis, by…
Jerom Langeveld
16 March 2017
Blog posts

Protein folding Application Note Now Online

The biological function of many macromolecules such as proteins and RNA are tightly coupled to their conformation and their conformational dynamic. The correct folding of a protein into its native state is essential for its biological function. Misfolded or unfolded proteins are known to be either (partially) inactive or to…
Jerom Langeveld
7 February 2017
C-Trap® Installed at ShanghaiTech UniversityBlog posts

C-Trap® Installed at ShanghaiTech University

LUMICKS is very excited to announce the first C-Trap® installation in Asia. The C-Trap® was installed at the lab of Assistant Professor Bo Sun at ShanghaiTech University in Shanghai, China. The group of Dr. Sun will use the C-Trap® to do a multitude of experiments involving DNA-protein interactions. His research…
Jerom Langeveld
6 February 2017
optical-tweezers-fibrin-fibersBlog posts

Effect of Mechanical Stress on Individual Vimentin Filaments Studied using the C-Trap®

The paper "Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain" using LUMICKS’ C-Trap® has recently been published in Physical Review Letters. Congratulations to all the authors! The study led by Prof. Sarah Köster, investigated the mechanical properties of the cytoskeleton in eukaryotic cells; and more specifically…
Jerom Langeveld
27 January 2017
Blog posts

C-Trap® installed at Rockefeller University

LUMICKS is proud to announce that a C-Trap® optical tweezers-fluorescence microscopy system was installed at Rockefeller University in the Liu Lab led by Assistant Professor Shixin Liu. Dr. Liu wil use the C-Trap to study how cells execute replication, transcription, translation and degradation processes in a coordinated manner, and how environmental changes…
Jerom Langeveld
14 December 2016
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