C-Trap Chemical Reviews AFS Biochemical Society Transactions

C-Trap™ and AFS™ systems mentioned in two review articles

We are proud to announce that two review articles refer to LUMICKS; one highlighting the C-Trap™ Optical Tweezers-Fluorescence Microscopy system and the other one specifying the AFS™ Acoustic Force Spectroscopy system.  Norregaard et al. (2017) reviews relevant theoretical tools to analyze data obtained from single-molecule … Continue Reading

multiple trap optical tweezers - fluorescence microscopy

New C-Trap™ acquired by the University of Göttingen

A new C-Trap™ system has recently been acquired by the Georg August University in Göttingen, Germany. The C-Trap™ was successfully installed in the lab of the “Nanoscale Imaging of Cellular Dynamics” research group, led by Prof. Dr. Sarah Köster, at the … Continue Reading

optical tweezers dna repair force extension manipulation visualization RAD51 Recombination

Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics

The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers … Continue Reading

Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to … Continue Reading

optical-tweezers-measure-DNA-replication-activity-states-with-force-fluorescence

Exonucleolysis and Replication by T7 DNA Polymerase Studied using Optical Tweezers and AFS™

The paper “Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity” has recently been published in the Biophysical Journal using LUMICKS’ AFS™ technology and optical tweezers. We would like to congratulate all the authors! In the paper … Continue Reading

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Acinetodin and Klebsidin Lasso Peptides Studied with AFS™ Technology

The first paper from one of our clients using AFS technology has been published in the journal ACS Chemical Biology led by prof. Mikhail Khodorkovskii. Congratulations to all the authors! In the paper named “Acinetodin and Klebsidin, RNA Polymerase Targeting … Continue Reading

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Effect of Mechanical Stress on Individual Vimentin Filaments Studied using the C-Trap™

The paper “Nonlinear Loading-Rate-Dependent Force Response of Individual Vimentin Intermediate Filaments to Applied Strain” using LUMICKS’ C-Trap™ has recently been published in Physical Review Letters. Congratulations to all the authors! The study led by Prof. Sarah Köster, investigated the mechanical … Continue Reading

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LUMICKS Featured in De Ingenieur

LUMICKS has been featured in the Dutch magazine De Ingenieur with an article named “Bewegend DNA-beeld”, or a moving DNA-image. De Ingenieur is a monthly Dutch magazine that specializes in technological developments and the policies surrounding them. This month’s edition … Continue Reading

optical-tweezers-fibrin-fibers

Interactions between Single Fibrin Fibers are Measured for the First Time

Cells and tissue change their structural properties to cope with large strains e.g. caused by blood flow and external stress. Understanding microstructural remodeling of the extracellular matrix requires knowledge of biological events down to the smallest scale. One of the … Continue Reading

DNA-repair-Nature

Paper Using LUMICKS Technology Published in Nature

Great news: Another paper using LUMICKS technology was published, this time in Nature! Congratulations to the authors. Several are now part of LUMICKS. In the study “Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA” Brouwer et al. … Continue Reading