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Imperial College London AFS installation atomic force spectroscopyBlog posts

Imperial College London Acquires AFS™ System

At Imperial College London, LUMICKS has installed an AFS™ system! This is the first AFS™ in London, where it will be used in the lab of Prof. David Rueda. It will aid in imaging the interaction and dynamics of various nucleic acid enzymes (such as polymerases, the activation induced cytidine deaminase,…
Jerom Langeveld
24 April 2017
AFS installed at LMT MunichBlog posts

New AFS™ installation at LMU

A new AFS™ Stand-alone was recently installed at Ludwig-Maximilians-Universität München in the Faculty of Physics. The Lab of Professor Jan Lipfert of the Chair for Biophysics and Molecular Materials will use the AFS™ to study the mechanosensitive response of multiple proteins in parallel. We wish Prof. Lipfert and his team success with the new…
Jerom Langeveld
19 April 2017
Multicolor detection of DNA overstretchingBlog posts

Multicolor Detection Application Note Now Online

Single-molecule force spectroscopy (SMFS) tools are widely used to study structural transitions of DNA during overstretching. However, as many of these tools only provide global information, the exact mechanisms that occur during these transitions remain unclear. Combining SMFS with visualization of local information could resolve this problem. Our Multicolor Detection application…
Jerom Langeveld
30 March 2017
optical tweezers dna repair force extension manipulation visualization RAD51 RecombinationBlog posts

Investigation of the Role of RAD52-DNA Complex in DNA Repair Using Optical Tweezers CTFM and Microfluidics

The article “Human RAD52 Captures and Holds DNA Strands, Increases DNA flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination” was recently published in Cell Reports. Congratulations to Dr. Ineke Brouwer and all co-authors! In this paper optical tweezers coupled with fluorescence microscopy and microfluidics were used to investigate…
Jerom Langeveld
24 March 2017
Blog posts

Study Published on DNA Compaction by Meiotic Protein SYCP3 using LUMICKS Technology

The article “Single-Molecule Observation of DNA Compaction by Meiotic Protein SYCP3” has recently been published in eLife Journal using optical tweezers-fluorescence microscopy. Congratulations to all the authors! In the paper by Syrjänen et al., optical tweezers-fluorescence microscopy was used to study the mechanism of SYCP3-mediated chromosome organization during meiosis, by…
Jerom Langeveld
16 March 2017
LUMICKS_AFS_installation_NUSBlog posts

LUMICKS’ AFS™ Installed at NUS

LUMICKS is happy to announce that an AFS™ system was installed at the National University of Singapore (NUS) in the lab of Professor Yan Jie. Professor Yan Jie and his group will use AFS™ along with their magnetic tweezers to research protein unfolding and DNA-protein interactions. We wish Professor Yan…
Jerom Langeveld
16 March 2017
Blog posts

Protein folding Application Note Now Online

The biological function of many macromolecules such as proteins and RNA are tightly coupled to their conformation and their conformational dynamic. The correct folding of a protein into its native state is essential for its biological function. Misfolded or unfolded proteins are known to be either (partially) inactive or to…
Jerom Langeveld
7 February 2017
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