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Blog posts

Screening of cancer targeting TCRs with the z-Movi®

With the quick development of new single-cell analysis technologies it is now possible to identify cancer-targeting T-Cell Receptors (TCRs) in a single experiment. A recent review published in Methods in Enzymology, presented the z-Movi® Cell Avidity Analyzer among the future platforms for the screening of cancer-targeting TCRs. “This technology is…
j.yeh
10 April 2020
Blog posts

Controlled ligand gradient through C-Trap® facilitates DSM measurements

A publication in the journal Micromachines describes how researchers managed to control the concentrations of DNA-binding dyes in single-molecule optical tweezers experiments on DNA. They established a controlled concentration gradient with the multi-channel laminar microfluidics system integrated with their C-Trap® correlated optical tweezers and confocal microscopy. The study demonstrates a…
j.yeh
19 March 2020
Blog posts

Study shows detailed properties of Ca2+ sensors during membrane fusion

A recent study in the Biophysical Journal shows how a Dutch research group measured and visualized dynamic interactions between membranes in the presence of Ca2+ sensors and synaptic inducers Syt1 and Doc2b. With the combined optical tweezers and confocal fluorescence microscopy configuration of the C-Trap®, the team revealed Ca2+ sensor-dependent…
j.yeh
12 March 2020
LUMICKS Top 250 Scale-upsBlog posts

LUMICKS in Top 250 Scale-ups 2020 of the Netherlands!

We're proud to be amongst the top 250 fastest growing scale-up companies in the Netherlands! Every year, the Erasmus Centre for Entrepreneurship (ECE) led by Prof. Dr. Justin Jansen, Academic Director of ECE and professor of Corporate Entrepreneurship at Rotterdam School of Management, researches the trends in the Dutch scale-up landscape. The…
j.yeh
9 March 2020
Blog posts

A new DNA–protein coupling procedure improves stability for DSM analyses

A recent study in Communications Chemistry shows how a research lab at AMOLF in the Netherlands optimized DNA–protein coupling to study dynamic processes requiring high forces and long-term assessments. Using their C-Trap® Optical Tweezers – Fluorescence Microscopy system, the team showed the superiority of a ligation-based strategy to create long…
j.yeh
5 March 2020
Blog posts

Study shows how chaperone enzyme ClpB processively translocates polypeptide loops using C-Trap® correlated optical tweezers and confocal microscopy

A new study published in Nature reports how researchers verified the intricate process of disaggregating entangled proteins by analyzing chaperone enzyme ClpB at a single-molecule level. The C-Trap® correlated optical tweezers and confocal microscopy enabled them to analyze how the member of the Hsp100 chaperone family translocates looped polypeptide substrates…
j.yeh
13 February 2020
Top banner image was licensed by Sergey Novikov / Shutterstock.comBlog posts

C-Trap® installed at Technical University of Munich

We are happy to announce the recent installation of the C-Trap® at the Technical University of Munich, Germany, in the lab of Prof. Matthias Rief. The installed C-Trap combines optical tweezers with 2-color fluorescence microscopy and will be used by students and postdocs in the Rief lab. Among other areas,…
j.yeh
11 February 2020
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