Blog posts

Blog posts

Single-molecule measurements with AFS® and optical tweezers reveal progressive assembly of viruses

The research lab of Dr. Gijs Wuite in the Netherlands recently published a single-molecule study in Science Advances, demonstrating the progressive self-assembly steps of viruses. Methods, such as optical tweezers and acoustic force spectroscopy (AFS®), enabled the researchers to study the transient and otherwise hard-to-verify steps associated with viral assembly.…

j.yeh14 May 2020

Dutch Tech Heroes Fighting COVID-19 | LUMICKS

Blog posts

LUMICKS featured in Dutch Tech Heroes Fighting COVID-19

LUMICKS has been featured as one of the 150+ companies in the overview of Dutch Tech Heroes Fighting COVID-19 published by Techleap.nl. The Dutch non-profit organization states: In the current crisis, the Netherlands is increasingly dependent on digital and technological solutions from startups and scale-ups. It is, therefore, more important than ever that…

j.yeh8 May 2020

Blog posts

New insights into the initiation of nucleotide excision repair found using C-Trap^®

A recent publication in PNAS shows how the catalytically inactive alkyltransferase-like protein (ATL) scans and recognizes detrimental DNA alkylation lesions. The C-Trap® with correlated optical tweezers and confocal microscopy enabled researchers to investigate how ATL interacts with DNA to identify alkyl lesions and interact with associated repair proteins. The findings…

j.yeh30 April 2020

Blog posts

Screening of cancer targeting TCRs with the z-Movi^®

With the quick development of new single-cell analysis technologies it is now possible to identify cancer-targeting T-Cell Receptors (TCRs) in a single experiment. A recent review published in Methods in Enzymology, presented the z-Movi® Cell Avidity Analyzer among the future platforms for the screening of cancer-targeting TCRs. “This technology is…

j.yeh10 April 2020

Blog posts

New mechanism of helicase-induced DNA unwinding from nicks found with the C-Trap^®

A study published in eLife shows how replication protein A (RPA) activates helicase Bloom syndrome protein (BLM) to unwind double-stranded DNA (dsDNA) bidirectionally from nicks. The C-Trap® enabled the researchers to simultaneously measure and visualize the DNA–protein interactions in real time. The findings highlight previously unknown mechanisms of BLM that…

j.yeh26 March 2020

Blog posts

Controlled ligand gradient through C-Trap^® facilitates DSM measurements

A publication in the journal Micromachines describes how researchers managed to control the concentrations of DNA-binding dyes in single-molecule optical tweezers experiments on DNA. They established a controlled concentration gradient with the multi-channel laminar microfluidics system integrated with their C-Trap® correlated optical tweezers and confocal microscopy. The study demonstrates a…

j.yeh19 March 2020

Blog posts

Impressions from LUMICKS’ Training Session for new users

As part of our commitment to support scientists through all the stages towards their first publication using our instruments, we often organize dedicated training sessions. In the case of the lab of Prof. Shi at Tsinghua University, this was in the form of a 5-day advanced training, providing in-depth knowledge…

Adrià Ferragut16 March 2020

Blog posts

Study shows detailed properties of Ca2+ sensors during membrane fusion

A recent study in the Biophysical Journal shows how a Dutch research group measured and visualized dynamic interactions between membranes in the presence of Ca2+ sensors and synaptic inducers Syt1 and Doc2b. With the combined optical tweezers and confocal fluorescence microscopy configuration of the C-Trap®, the team revealed Ca2+ sensor-dependent…

j.yeh12 March 2020

Blog posts

LUMICKS in Top 250 Scale-ups 2020 of the Netherlands!

We're proud to be amongst the top 250 fastest growing scale-up companies in the Netherlands! Every year, the Erasmus Centre for Entrepreneurship (ECE) led by Prof. Dr. Justin Jansen, Academic Director of ECE and professor of Corporate Entrepreneurship at Rotterdam School of Management, researches the trends in the Dutch scale-up landscape. The…

j.yeh9 March 2020

Blog posts

A new DNA–protein coupling procedure improves stability for DSM analyses

A recent study in Communications Chemistry shows how a research lab at AMOLF in the Netherlands optimized DNA–protein coupling to study dynamic processes requiring high forces and long-term assessments. Using their C-Trap® Optical Tweezers – Fluorescence Microscopy system, the team showed the superiority of a ligation-based strategy to create long…

j.yeh5 March 2020

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