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New insights into Cas9 off-target activity

The paper “DNA stretching induces Cas9 off-target binding and cleavage” was just published in Nature Structural and Molecular Biology. Congratulations to all the authors! In this paper, scientists at the MRC London Institute of Medical Sciences and AstraZeneca studied how CRISPR-Cas9 differentiates between on-targets and off-targets. They used the C-Trap®…
j.yeh
8 March 2019
C-Trap m-Trap 2019 Brochure CoversBlog posts

Step into the unresolved with the Surface Assay Toolkit

During BPS19, we introduced the Surface Assay Toolkit! A unique assortment of new features that enable scientists to investigate the cytoskeleton from a whole new dynamic perspective. The Surface Assay Toolkit brings together the C-Trap™ and m-Trap™ optical tweezers with:  Label-free surface imaging using IRM;  Rapid fluorescent imaging in solution using Widefield;  Fluorescence surface imaging using TIRF;  High throughput experimental workflow at the surface. Download the 2019…
j.yeh
7 March 2019
C-Trap Installation at UC MercedBlog posts

C-Trap™ installed at UC Merced

A C-Trap™, optical tweezers coupled with fluorescence microscopy, has been successfully installed at the University of California, Merced. The system is shared by the research groups of Prof. Eva de Alba and Prof. Victor Muñoz. Their labs focus on the study of proteins, which are involved in almost all cellular processes. This makes the…
Jerom Langeveld
18 February 2019
LUMICKS Boston Office OpeningBlog posts

LUMICKS Boston Office Opening

Last Friday we officially opened our own office in Boston! After some serious ribbon cutting, the US team celebrated this milestone with delicious food and champagne. We would like to warmly welcome you to stop by whenever you are in the Boston area. Do you notice the typical Dutch details…
j.yeh
11 February 2019
Blog posts

The Scientist Magazine features z-Movi®;

We couldn't have put the essence of our z-Movi®; in better words than the author of this article in The Scientist: "Just as music pulls some folks to the dance floor while others remain stuck to their chairs, sound can now be used to pull some cells loose from their substrate while other cells…
j.yeh
25 January 2019
Blog posts

C-Trap installed at TU Delft

We are thrilled about the recent C-Trap® installation in the Department of Bionanoscience at the TU Delft, one of the leading universities in The Netherlands! The groups of Prof. Nynke Dekker and Prof. Marileen Dogterom will use the C-Trap to study the dynamic aspects of DNA replication and cytoskeleton-based processes,…
Jerom Langeveld
13 December 2018
z-Movi has been featured in ScienceBlog posts

z-Movi® featured in Science

Our latest product, the z-Movi®;, has been featured in the latest issue of the journal Science! The z-Movi uses acoustic force manipulation to query the interaction strengths of cells with their cognate binding partners. It is based on a lab-on-a-chip assay that allows the assessment of thousands of cell-cell and cell-ligand interactions…
j.yeh
5 December 2018
phase separation IDP researchBlog posts

New C-Trap™ Installed at the University at Buffalo

LUMICKS successfully installed a C-Trap® optical tweezers–fluorescence microscopy system in the lab of Assistant Professor Priya Banerjee at the University at Buffalo. The group of Dr. Banerjee will use the C-Trap to investigate the structural dynamics and phase behavior of intrinsically disordered proteins (IDPs). IDPs are characterized by conformational plasticity and structural heterogeneity,…
Jerom Langeveld
17 October 2018
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