Publication

Blog posts

Researchers used u-Flux™ and optical tweezers to measure RecBCD activity

In a study performed at the Technion – Israel Institute of Technology, researchers used our u-Flux™ laminar flow microfluidics system combined with optical tweezers to investigate the activity of the Escherichia coli enzyme RecBCD and its subunits. The paper titled “Synergy between RecBCD subunit is essential for efficient DNA unwinding” appeared…

j.yeh11 July 2019

Blog posts

Two papers give new insights on protein droplets using LUMICKS’ C-Trap™

Two new papers published at Physical Review Letters and Nature Communications give new insights on protein droplets. Congratulations to all the authors! Jawerth et al. developed a method to investigate the frequency-dependent rheology and surface tension of protein droplets. They used the C-Trap™ optical tweezers – fluorescence microscope to trap…

j.yeh31 May 2019

Blog posts

New insights into Cas9 off-target activity

The paper “DNA stretching induces Cas9 off-target binding and cleavage” was just published in Nature Structural and Molecular Biology. Congratulations to all the authors! In this paper, scientists at the MRC London Institute of Medical Sciences and AstraZeneca studied how CRISPR-Cas9 differentiates between on-targets and off-targets. They used the C-Trap®…

j.yeh8 March 2019

New C-Trap® Installed at the University at Buffalo

Blog posts

New insights on the formation and dynamics of membraneless organelles using C-Trap™

Congratulations to Dr. Priya R. Banerjee and his research group at University at Buffalo, who just published their paper in Biomolecules! In the paper titled “Molecular crowding tunes material states of ribonucleoprotein condensates” they investigated how entropic forces contribute to the formation and dynamics of membraneless organelles. Using their C-Trap…

j.yeh28 February 2019

Blog posts

Unraveling the Kinetics and Strength of T Cell Adhesion to Fibronecting using z-Movi^®;

A new study in Cell Reports shows the first results obtained using z-Movi; ! Kamsma et al. used the z-Movi to measure the adhesion forces and kinetics of CD4+ T lymphocytes (CD4) to fibronectin in living conditions. They then investigated how these properties are influenced by interleukin-7 (IL-7), the main regulatory cytokine of CD4 cells. The results…

Jerom Langeveld2 October 2018

Measure Cell Mechanics with Acoustic Force Spectroscopy

Blog posts

Novel Method for Single-Cell Mechanical Probing using LUMICKS’ AFS™ System

The article ‘Probing cellular mechanics with Acoustic Force Spectroscopy’ has recently been published in the journal Molecular Biology of the Cell. Congratulations to all the authors on their inspiring research! Undergoing deformations plays a vital role in the function of Red Blood Cells (RBCs) and could be used as a biomarker,…

Jerom Langeveld10 July 2018

Blog posts

Novel Insights on the Mechanical Properties of IFs using LUMICKS’ Technology

The journal Science Advances has recently published the paper ‘Viscoelastic properties of vimentin originate from nonequilibrium conformational changes’. We would like to congratulate Prof. Dr. Sarah Köster and all co-authors for their great work on intermediate filaments (IFs)! IFs are one of the filament systems which constitute the cytoskeleton of…

Jerom Langeveld18 June 2018

Blog posts

Method to Quantify Local Force Distribution within Biomolecular Systems

The journal Nano Letters has recently published the article “Quantifying Local Molecular Tension Using Intercalated DNA Fluorescence”. We would like to congratulate all the authors! By using optical tweezers coupled with fluorescence microscopy, Dr. King et al. (2018) studied the ability of cyanine intercalator dyes to quantify the molecular tension…

Jerom Langeveld25 April 2018

optical tweezers dna repair force extension manipulation visualization RAD51 Recombination

Blog posts

Investigation of the Interaction of RAD51 with ssDNA Using CTFM and X-ray Crystallography

Recently, the paper “Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA" has been published in The EMBO Journal. Congratulations to Dr. Ineke Brouwer and all co-authors! Brouwer et al. combined Correlative Optical Tweezers-Fluorescence Microscopy (CTFM) with X-ray crystallography to investigate the function of human RAD51…

Jerom Langeveld20 March 2018

strand-displacement polymerization investigated with u-Flux microfluidics microfluidics laminar flow cell

Blog posts

Strand-Displacement Polymerization by Reverse Transcriptase Investigated using LUMICKS’ u-Flux™

The journal Nucleic Acids Research has recently published the paper "Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase". We would like to congratulate the authors! Malik et al. (2017) used optical tweezers and, among other technologies, microfluidics to study the enzymatic activity of the murine leukemia Virus reverse transcriptase (RT). RT catalyzes the formation of an integration-competent double-stranded DNA…

Jerom Langeveld26 September 2017

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