C-Trap

Blog posts

Deciphering the Dynamic Mechanisms of Thymine DNA Glycosylase (TDG) in DNA Repair

Explore our latest blog post on thymine DNA glycosylase (TDG), where we delve into groundbreaking research using single-molecule assays to understand TDG’s crucial role in DNA repair. Discover how these insights could lead to advanced therapeutic strategies.

Chenlu Yu5 December 2024

Blog posts

Shu Complex: A New Frontier in DNA Repair and Cancer Therapy

Explore the groundbreaking research on the Shu Complex and its role in enhancing RAD51-mediated DNA repair. Discover how this vital mechanism can be a new target in cancer therapy and the innovative methods used in DNA repair studies.

Chenlu Yu22 November 2024

Blog posts

Chromatin remodeling dynamics revealed at the single-molecule level in a recent pioneering study

Explore groundbreaking research on chromatin remodeling dynamics using the C-Trap, revealing 'hopping' and 'sliding' mechanisms of chromatin remodelers on DNA. Gain insights into the push-pull model and its implications for gene regulation and genomic integrity. Dive into the latest advancements in genomic research.

Chenlu Yu30 May 2024

DNA repair pathwya via PARP1-DNA co-condensation

Blog posts

Securing Broken DNA Ends: PARP1’s Vital Role in Co-Condensation with DNA

Explore how PARP1's involvement in DNA repair through condensate formation secures genetic integrity. Read this blog to understand the dynamics of DNA repair processes in real-time.

Chenlu Yu19 March 2024

Blog posts

Towards safe and precise gene therapies: revealing the impact of DNA Supercoiling on CRISPR-Cas9 specificity

CRISPR-Cas9 represents one of the most impactful discoveries in the field of genetic engineering and medicine of recent times. Its discovery catalyzed a paradigm shift in the treatment approach to many genetic diseases, paving the way to simple and effective gene therapy for a large class of diseases. In fact, the…

Chenlu Yu5 December 2023

Blog posts

The C-Trap uncovers new insights into the mechanisms for ATP-dependent chromatin remodeling

PICH (Plk1-interacting checkpoint helicase) belongs to the SNF2 family of ATP-dependent chromatin remodelers. However, what makes PICH unique is that it lacks a nucleotide-binding domain despite having a great affinity for bare DNA. Because of this molecular structure, it has been hypothesized that the binding of PICH to chromatinized bridges…

Chenlu Yu13 June 2023

Blog posts

C-Trap^® experiments reveal novel mechanism for transcription termination in bacteria

New insights into the regulation of transcription termination have been revealed by researchers from the lab of Shixin Liu at The Rockefeller University, New York, in a recent publication in Molecular Cell. Using the powerful LUMICKS C-Trap® technology that allows the direct observation of molecular mechanisms, they were able to…

Chenlu Yu31 March 2023

Blog posts

100th study using the C-Trap^® provides crucial insights into how the Smc5/6 complex stabilizes certain DNA structures

A recent study published in Nature Communications led by Shixin Liu from The Rockefeller University, New York, demonstrates how the C-Trap® can be used to directly visualize and observe molecular mechanisms in action, leading to better and faster insights into critical molecular processes. This study marks an important milestone for LUMICKS,…

Chenlu Yu28 March 2023

Blog posts

C-Trap^® experiments shed light on the mechanisms that govern Structural Maintenance of Chromosome (SMC) Complexes

In two recent scientific publications, Johannes Stigler and his team from the Gene Center of the Ludwig-Maximilians-University Munich, Germany, set out to mechanistically describe the action of the Structural Maintenance of Chromosome (SMC) Complexes using LUMICKS’ C-Trap® technology. By performing dynamic single-molecule experiments coupled with real-time visualization, they were able…

Chenlu Yu9 March 2023

Blog posts

Unlocking the secrets of DNA-binding proteins in nuclear extracts using dynamic single-molecule analysis

For a long time, scientists have been striving to understand how DNA-binding proteins interact with DNA substrates in real time at the single-molecule level, using a variety of imaging techniques and optical platforms. However, for most of these methods scientists always had to choose between studying purified proteins under specific…

Chenlu Yu28 February 2023

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