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Cell Avidity screening deployed by T cell pioneers to accelerate the identification of functional TCRs

The TCR field continues to rely on a protracted preclinical selection process, which utilizes conventional assays such as affinity and peptide titrations that correlate poorly with T-cell functionality. Optimal TCR selection necessitates thorough preclinical characterization, prompting Carr et al., to focus on comprehensive cell-cell binding assessment to enhance preclinical decision-making.
niels
25 June 2024
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