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Intermediate filament Archives - LUMICKS

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The softening effect of vimentin filament phosphorylation measured with the C-Trap®

A recent study published in the journal Nanoscale shows how post-translational phosphorylation and proteins binding phosphorylated sites regulate the stiffness of vimentin filaments. The researchers combined several analytical approaches and instruments, including the C-Trap® optical tweezers, to define the role of these modifications and interactions on the mechanical properties of vimentin. Apart from contributing…
Santiago Gisler
16 February 2021
News

Electrostatic effects on vimentin stiffness demonstrated with the C-Trap®

A recently published study from the lab of Prof. Sarah Köster at the University of Göttingen investigated how electrostatic conditions influence the mechanical properties of intermediate filament vimentin, such as structural stability. The researchers assessed these features by stretching the protein in different buffer conditions, using the C-Trap® with correlated optical…
Santiago Gisler
6 August 2020

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