Applications Archive

Cell–extracellular matrix interactions: Unraveling the kinetics and strength of cellular adhesion

Cell–extracellular matrix interactions: Unraveling the kinetics and strength of cellular adhesion The z-Movi® is a useful tool to obtain insights into cell adhesion processes. Here, Kamsma et al. used the z-Movi® to resolve the adhesion forces and kinetics between CD4+ T lymphocytes (CD4) and fibronectin.They identified three interaction states between…

getyos21 December 2020

Evaluate the avidity of T cells engaged by cell engagers

Evaluate the avidity of T cells engaged by cell engagers Cell engagers (CE) are molecules that can steer immune cells, such as T cells, NK cells, and macrophages, towards cancer cells. Most CEs are bispecific antibodies (BsAb), powerful tools adopted by immuno-oncology that can enhance the recruitment of T cells…

Adrià Ferragut3 March 2023

Evaluate the avidity of T cells engaged by bispecific antibodies

Evaluate the avidity of T cells engaged by bispecific antibodies Bispecific antibodies are power tools adopted by immuno-oncology that can enhance the recruitment of T cells to specific cancer cells. They facilitate the formation of the immunological synapses, which is key for a proper T-cell response against target cancer cells.…

getyos21 December 2020

Use avidity to identify the best NK cell with optimal response

Use avidity to identify the best NK cell with optimal response In addition to autologous cellular therapy, allogeneic strategies may facilitate an off-the-shelf solution, including NK cells as a prime example. In this assay, researchers from Glycostem Therapeutics B.V. compared cell avidity data with cell killing by evaluating NK functionalities…

getyos21 December 2020

Improve the functional correlation of TCR T cells by replacing affinity with avidity

Improve the functional correlation of TCR T cells by replacing affinity with avidity This study aimed to screen a panel of affinity-tuned TCR T cells and find the most potent candidates. T cells with high antigen-affinity TCRs are, in general, functionally superior to those with low antigen-affinity. However, upon breaching an…

getyos21 December 2020

Optimize CAR design using cell avidity — a reliable predictor of T-cell efficacy

Avidity enhancement effectively eradicates tumors in Acute Myeloid Leukemia (AML) AML, the most common type of leukemia in adults, poses significant clinical challenges due to its resistance to therapies and its bleak prognosis. To date, little is known about the effectiveness of CAR T cell therapies on myeloid cancers such…

getyos21 December 2020

Study and visualize DNA repair mechanisms at the nanoscale

Many repair processes exist to ensure genetic stability, such as nucleotide excision repair (NER), homologous recombination (HR), and non-homologous end-joining (NHEJ). However, deregulations can occur in these pathways and often lead to disease development like cancer or neurodegenerative disorders. In order to successfully develop new therapies, it is crucial to…

j.yeh28 October 2021

Study and visualize diffusive and processive DNA-protein interactions at the nanoscale level

DNA transcription is the key element that defines cellular identity and status. By clearly understanding the mechanism of gene regulation and expression at this level scientists will be able to grasp many causes of diseases and develop possible cures. Until now, molecular biology and biochemistry methods have highly contributed to…

getyos9 December 2020

Visualize DNA editing mechanisms at the nanoscale level

CRISPR/Cas9 is a highly popular genome-editing tool and a trending research topic. Current research is focused on fully understanding Cas9 function under different circumstances to exclude off-target binding events and ensure its precision during DNA editing applications. However, there are still many challenges in performing this research, including missing control…

j.yeh21 June 2021

Study and visualize DNA replication mechanisms at the nanoscale

The proper function and control of DNA replication is critical for cell proliferation and genomic integrity. During this highly complex process, numerous different proteins work together in the replisome. Despite the large body of knowledge surrounding the composition of the replisome and the function of DNA replication, many questions regarding…

getyos8 December 2020

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Cell–extracellular matrix interactions: Unraveling the kinetics and strength of cellular adhesion

Evaluate the avidity of T cells engaged by cell engagers

Evaluate the avidity of T cells engaged by bispecific antibodies

Use avidity to identify the best NK cell with optimal response

Improve the functional correlation of TCR T cells by replacing affinity with avidity

Optimize CAR design using cell avidity — a reliable predictor of T-cell efficacy

Study and visualize DNA repair mechanisms at the nanoscale

Study and visualize diffusive and processive DNA-protein interactions at the nanoscale level

Visualize DNA editing mechanisms at the nanoscale level

Study and visualize DNA replication mechanisms at the nanoscale

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