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Evaluate the avidity of T cells engaged by bispecific antibodies

Evaluate the avidity of T cells engaged by bispecific antibodies Bispecific antibodies are power tools adopted by immuno-oncology that can enhance the recruitment of T cells to specific cancer cells. They facilitate the formation of the immunological synapses, which is key for a proper T-cell response against target cancer cells.…
getyos
21 December 2020

Use avidity to identify the best NK cell with optimal response

Cell avidity depict stronger binding of INKmune-primed NK cells that eradicate residual disease Cell avidity measurements compared NK cell binding (IL-2, IL-15, and INKmune-primed) to NK-resistant SKOV3 cancer cells. INKmune-primed NK cells showed superior avidity, forming stronger immune synapses for effective cancer cell killing (Figure 1). Unlike IL-2/IL-15 activation with…
getyos
21 December 2020

Directly observe molecular DNA repair mechanisms as they happen

The order of molecular events is inaccessible with established biochemistry assays? Characterize the (dis-)assembly kinetics if repair complexes based on real-time data! Understanding the sequence of events in assembling multi-protein complexes is crucial for comprehending DNA repair processes and identifying potential drug targets. LUMICKS’ dynamic single-molecule approach provides such insights,…
getyos
19 April 2024

Cell Avidity: a superior predictor of in vivo efficacy of CAR-T cells

NEW: Cell Avidity identified the poor clinical efficacy of the APRIL CAR-T cell therapy In a recent JITC paper named  “Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T cell therapy’’  published by the team of Dr. Lydia…
getyos
21 December 2020
C-Trap DNA Repair

Directly observe molecular DNA repair mechanisms as they happen

DNA repair processes, such as nucleotide excision repair (NER), homologous recombination (HR), and non-homologous end-joining (NHEJ) ensure genetic stability. However, deregulations can occur in these pathways and often lead to disease development like cancer or neurodegenerative disorders. In order to successfully develop new therapies, it is crucial to research DNA…
j.yeh
28 October 2021

Visualize DNA editing mechanisms at the nanoscale level

CRISPR/Cas9 is a highly popular genome-editing tool and a trending research topic. Current research is focused on fully understanding Cas9 function under different circumstances to exclude off-target binding events and ensure its precision during DNA editing applications. However, there are still many challenges in performing this research, including missing control…
j.yeh
21 June 2021
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