Evaluate the avidity of T cells engaged by bispecific antibodies

Evaluate the avidity of T cells engaged by bispecific antibodies Bispecific antibodies are power tools adopted by immuno-oncology that can enhance the recruitment of T cells to specific cancer cells. They facilitate the formation of the immunological synapses, which is key for a proper T-cell response against target cancer cells.…
getyos
21 December 2020

Use avidity to identify the best NK cell with optimal response

Use avidity to identify the best NK cell with optimal response In addition to autologous cellular therapy, allogeneic strategies may facilitate an off-the-shelf solution, including NK cells as a prime example. In this assay, researchers from Glycostem Therapeutics B.V. compared cell avidity data with cell killing by evaluating NK functionalities…
getyos
21 December 2020
C-Trap DNA Repair

Study and visualize DNA repair mechanisms at the nanoscale

Many repair processes exist to ensure genetic stability, such as nucleotide excision repair (NER), homologous recombination (HR), and non-homologous end-joining (NHEJ). However, deregulations can occur in these pathways and often lead to disease development like cancer or neurodegenerative disorders. In order to successfully develop new therapies, it is crucial to…
Nelli Bossert
28 October 2021
C-Trap Transcription

Study and visualize DNA transcription mechanisms at the nanoscale

DNA transcription is the key element that defines cellular identity and status. By clearly understanding the mechanism of gene regulation and expression at this level scientists will be able to grasp many causes of diseases and develop possible cures. Until now, molecular biology and biochemistry methods have highly contributed to…
getyos
9 December 2020

Visualize DNA editing mechanisms at the nanoscale level

CRISPR/Cas9 is a highly popular genome-editing tool and a trending research topic. Current research is focused on fully understanding Cas9 function under different circumstances to exclude off-target binding events and ensure its precision during DNA editing applications. However, there are still many challenges in performing this research, including missing control…
Nelli Bossert
21 June 2021
C Trap DNA Replication

Study and visualize DNA replication mechanisms at the nanoscale

The proper function and control of DNA replication is critical for cell proliferation and genomic integrity. During this highly complex process, numerous different proteins work together in the replisome. Despite the large body of knowledge surrounding the composition of the replisome and the function of DNA replication, many questions regarding…
getyos
8 December 2020
C-Trap DNA Organization

Study and visualize DNA organization mechanisms at the nanoscale

Motor packaging activity and stepping behavior with base pair resolution Here, we tethered a φ29 DNA packaging motor and its dsDNA substrate between two optically trapped beads. Using optical tweezers we can perform pulling and equilibrium experiments to probe the structural dynamics and conformational changes during genome packaging.As packaging proceeds, the DNA…
getyos
9 December 2020

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