z-Movi®
Cell Avidity Analyzer

Predictive, Reproducible, Fast

z-Movi®

Benchtop Cell Avidity Analyzer

Predictive, Reproducible, Fast

Measure cell-target binding strengths with the z-Movi® Cell Avidity Analyzer to accelerate the development of immunotherapeutic strategies.

The z-Movi® is a unique instrument that measures the avidity between immune cells and their targets, enabling you to identify the most potent immunotherapeutic effector cells. This new technology provides you with predictive, reproducible, and fast high-throughput results at a single-cell resolution without compromising cell viability. All within a compact little box that easily fits inside the flow hood for sterile and safe sample handling.

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Measure cell-target binding strength with the z-Movi®  Cell Avidity Analyzer to accelerate your immunotherapy development.

z-Movi® is a unique instrument that enables you to identify the most potent effector cells by quantifying avidity for their target cell. This new technology provides you with predictive, reproducible, and fast high-throughput results at the single-cell level without compromising cell viability. All within a compact little box that is safe and easy to use.

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Testimonials and publications

Testimonials and Publications

Applications in
immuno-oncology

The z-Movi® Cell Avidity Analyzer offers you a fast and simple solution for validating and optimizing your immunotherapeutic cells in a highly predictive and reproducible manner.

Cell avidity measurements enable you to compare several types of immunotherapeutic strategies, including CAR T cells, TCR T cells, bispecific antibody-engaged T cells, and NK cells.  Browse our extended list of applications to discover how this technology can benefit your research.

Cell Avidity - T cell Interactions

Applications in Immuno-oncology

Cell Avidity - T cell Interactions

The z-Movi® Cell Avidity Analyzer offers you a fast and simple solution for validating and optimizing immunotherapeutic strategies in a highly predictive and reproducible manner.

Cell avidity measurements enable you to screen T cells, CAR-Ts, Bispecifics, Transgenic TCRs, NK cells and many more.  Browse our extended list of applications to discover how these technologies can benefit your research.

Explore the features

Explore how this benchtop instrument delivers predictive, reproducible, and fast data for your experiments.

Direct measurement of binding avidity

The z-Movi® introduces the robustness of a biophysical-based method to immuno-oncology to uncover the essential properties of effector cells.

Single-cell resolution

Measures the binding strength between every effector cell and its target to ensure that not a single piece of information is lost. Because each cell matters.

High throughput

Analyzes avidities of up to 400 cells in a single run and generates instant statistically relevant data. The fast workflow enables you to measure multiple experimental conditions per day.

Safe to cells

Offers non-invasive acoustics to measure avidity, leaving your cells healthy and viable.

Fluorescence cell imaging

Distinguishes and follows individual fluorescent effector cells with unparalleled accuracy as they detach from their target cells and gather at the acoustic node.

Compact

Small enough to fit inside a flow hood, providing sterile cell handling and protective conditions when working with dangerous reagents.

Explore the features

See how this compact, benchtop instrument delivers predictive, reproducible and fast data and results for all your experiments.

Direct measurement of binding avidity

The z-Movi® introduces the robustness of a biophysical-based method to immuno-oncology to uncover the essential properties of effector cell populations.

 

Single-cell resolution

Measures the binding strength between every effector cell and its target to ensure that not a single piece of information is lost. Because each cell matters.

 

High throughput

Analyzes avidities of up to 400 cells in a single run and generates instant statistically relevant data. The fast workflow and reusable z-Movi Chip enable you to measure multiple experimental conditions per day.

 

Safe to cells

Offers non-invasive acoustics to measure avidity, leaving your cells healthy and viable.

 

Fluorescence cell imaging

Distinguishes and follows individual fluorescent effector cells with unparalleled accuracy as they detach from their target cells and gather at the acoustic node.

Compact

Small enough to fit inside a flow hood, providing sterile cell handling and protective conditions when working with dangerous reagents.

Rapid experiments with the optimized workflow

Rapid experiments through an optimized workflow

We have optimized the workflow of the z-Movi® to facilitate the user experience and provide you with reliable and reproducible results in a matter of minutes. The z-Movi Chip is specialized to simplify cell culturing and maintain your samples in physiological conditions while you perform experiments. Once you have performed one run of analyses, you can simply flush in a new batch of effector cells. Running multiple chips sequentially allows you to measure several  experimental conditions per day.

Step 1
Culture target cells

Step 2
Flush in your T cells

Step 3
Incubate

Step 4
Start acoustic force

Step 5
Sit back and watch your measurements in real time

Step 6
Flush in a new round of T cell population

Step 7
Incubate

Step 8
Start acoustic force

Step 9
Sit back and watch your avidity measurements results in real time

Step 10
Repeat again for another 3 rounds!

Rapid experiments with the optimized workflow

Rapid experiments through an optimized workflow

We have optimized the workflow of the z-Movi® to facilitate the user experience and provide you with reliable and reproducible results in a matter of minutes. The z-Movi Chip is specialized to simplify cell culturing and maintain your samples in physiological conditions while you perform experiments. Once you have performed one run of analyses, you can simply flush in a new batch of effector cells. Running multiple chips sequentially allows you to measure several  experimental conditions per day.

Step 1
Culture target cells

Step 2
Flush in your T cells

Step 3
Incubate

Step 4
Start acoustic force

Step 5
Sit back and watch your measurements in real time

Step 6
Flush in a new round of T cell population

Step 7
Incubate

Step 8
Start acoustic force

Step 9
Sit back and watch your avidity measurements results in real time

Step 10
Repeat again for another 3 rounds!

Rapid experiments with the optimized workflow

Rapid experiments through an optimized workflow

We have optimized the workflow of the z-Movi® to facilitate the user experience and provide you with reliable and reproducible results in a matter of minutes. The z-Movi Chip is specialized to simplify cell culturing and maintain your samples in physiological conditions while you perform experiments. Once you have performed one run of analyses, you can simply flush in a new batch of effector cells. Running multiple chips sequentially allows you to measure several  experimental conditions per day.

“Acoustic force measurements allow for the first time to make an exact determination of the force that is necessary to separate two cell partners, which would in the end allow […] to introduce a new parameter in the characterization of T cells.”

Prof. Matthias Leisegang, group leader at Charité – Universitätsmedizin Berlin.

“Acoustic force measurements allow for the first time to make an exact determination of the force that is necessary to separate two cell partners, which would in the end allow […] to introduce a new parameter in the characterization of T cells.”

Prof. Matthias Leisegang, group leader at Charité – Universitätsmedizin Berlin.

“Acoustic force measurements allow for the first time to make an exact determination of the force that is necessary to separate two cell partners, which would in the end allow […] to introduce a new parameter in the characterization of T cells.”

Prof. Matthias Leisegang, group leader at Charité – Universitätsmedizin Berlin.

Dive in and discover our software platform

The only software that analyzes the avidity of hundreds of cells in parallel and real time

In collaboration with end users, we have developed a fast and intuitive workflow that takes you from defining your parameters to viewing your data in no time. The powerful tracking algorithms for cell detection and measurements are performed in the background while the software generates your data live on your screen.

Powerful detection algorithms

Real-time avidity data analysis

Figure-ready data plotting

Royalty-free license

Dive in and discover our software platform

The only software that analyzes avidity in real-time hundreds of cells in parallel

In collaboration with end-users, we have developed a fast and intuitive workflow that takes you from defining your parameters to viewing your data in no-time. The powerful tracking algorithms for cell detection and measurements are performed in the background while the software generates your data live on your screen.

Powerful detection algorithms

Real-time avidity data analysis

Figure-ready data plotting

Royalty-free license

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