z-Movi™

Benchtop Cell Avidity Analyzer

z-Movi™

Benchtop Cell Avidity Analyzer

Quantify T cell interactions based on the avidity to their target – within minutes

z-Movi™ is the only instrument that enables you to find the most potent immune cells out of a heterogeneous population and quantify their binding strength to their target. All this in a label-free, high-throughput, and single-cell manner.

Featured in:

Find the right population of immune cells

z-Movi™ is the only instrument that can directly measure the avidity, or overall strength of interaction between cells  (e.g., CAR-T and target tumor cells) or between cells and ligands (e.g., TCR-ligand interactions).

Introduced in 2018, this new technology based on acoustic waves paves the way for the study of yet unexplored avenues in basic and translational research, impacting applications where cell-cell interactions are key, including immunotherapy, antigen presentation, therapeutic antibodies, vaccination, immunological synapse and cellular adhesion.

High throughput at single-cell resolution

Label-free and non-invasive

Easy to use

Compact and safe

COMING SOON!

Avidity-based screening and enrichment

Applications

Whether you are aiming to make novel discoveries in the life sciences or develop successful therapies, we work on a personal level to find the right solution for you. Browse our extended list of applications to discover how these technologies can benefit your research.

The novel avidity-based screening and enrichment principle

1. Immobilize your target tumor cells or ligands on the surface of the z-Movi chip and insert the solution containing your effector cells (e.g., CAR-T, NK cells etc.) of interest.

2. Screen your effector cells by applying an acoustic force ramp. Low avidity cells require less force to be separated from their targets and will detach before high avidity cells.

3. While the force is increased, cells are flushed out.

4. Characterize each effector cell population fraction both absolutely and relatively to other populations by gradually increasing the force and measuring their interaction strengths over time.

The z-Movi System

z-Movi Chips

Lab-on-a-chip with microfluidic channel, allowing you to easily insert both your target sample and cells of interest in a highly-controlled environment.

Cell enrichment

With up to 2 inlet channels individually controlled to create gradients, and up to 8 outlet channels to collect your different cell population fractions.

COMING SOON!

Workflow-focused software package

With a fast and intuitive workflow you go from defining your parameters to viewing your data. The powerful tracking algorithms for the detection and measurement of cells are performed in the background while your data is being generated realtime.

Temperature Control

Perform your experiments under relevant conditions.

Brightfield microscopy

Low power LED illumination to image cells in a non-destructive manner.

Z-movi

The z-Movi System

Z-movi

z-Movi Chips

Lab-on-a-chip with microfluidic channel, allowing you to easily insert both your target sample and cells of interest in a highly-controlled environment.

Cell enrichment

With up to 2 inlet channels individually controlled to create gradients, and up to 8 outlet channels to collect your different cell population fractions.

COMING SOON!

Workflow-focused software package

With a fast and intuitive workflow you go from defining your parameters to viewing your data. The powerful tracking algorithms for the detection and measurement of cells are performed in the background while your data is being generated realtime.

Temperature Control

Perform your experiments under relevant conditions.

Brightfield microscopy

Low power LED illumination to image cells in a non-destructive manner.

Want to learn more?

Would you like to receive exclusive news on the latest products, single-molecule events and breakthrough science from us?


You can unsubscribe at any time from our marketing emails. By submitting the form you agree to LUMICKS' privacy policy.

Take your research to the next level.

Get exclusive news on the latest products, single-molecule events and breakthrough science.

Newsletter pop up
By clicking the subscribe button you agree to LUMICKS’ privacy policy.