z-Movi™

Cell Avidity Analyzer

z-Movi™

Cell Avidity Analyzer

Screen, quantify, and separate cells based on their cellular binding strength

z-Movi™ is the first instrument that enables you to find and collect the most potent immune cells out of a heterogeneous population and quantify their binding strength to their target. All this in a label-free, high throughput, and single-cell manner.

What is avidity?

Avidity is the combined strength of multiple interactions between a cell and its target. For example, the strength of interaction between an immune cell and a tumor cell is known to be primarily dictated by the affinity of the T cell receptor (TCR) to the antigen presented on the tumor site.

However, often other factors will come into play and affect the overall interaction between these two cells, such as the presence of co-receptors, TCR clustering, or even the orientation and valency of each binding partner. So while affinity describes the strength of a single interaction, avidity takes into account the overall binding strength taking place and determines how strongly a cell interacts with its target.

Find and isolate the right population of immune cells

z-Movi™ is the first instrument that can directly measure the avidity, or overall strength of interaction between cells and subsequently enrich cells of interest.

Introduced in 2018, this new technology based on acoustic waves paves the way for the study of yet unexplored avenues in basic and medical research, impacting applications where cell-cell interactions are key, including immunotherapy, antigen presentation, vaccination, immunological synapse, cellular adhesion and therapeutic antibodies.

Avidity-based screening and enrichment

High throughput at single-cell resolution

Label-free and non-invasive

Compact and safe

Easy to use

Applications

Whether you are aiming to make novel discoveries in the life sciences or develop successful therapies, we work on a personal level to find the right solution for you. Browse our extended list of applications to discover how these technologies can benefit your research.

The novel avidity-based screening and enrichment principle

1. Immobilize your target cells or ligands on the surface of the z-Movi chip and insert the solution containing your cells of interest.

2. Screen your cells by applying a force ramp. Low avidity cells require less force to be separated from their targets and will detach before high avidity cells.

3. While the force is increased, cells are flushed out collected.

4. Characterize each cell population fraction both absolutely and relatively to other populations by gradually increasing the force and measuring the interaction strengths over time.

The z-Movi System

z-Movi flow cells

Lab-on-a-chip with microfluidic channel, allowing you to easily insert both your target sample and cells of interest in a highly-controlled environment.

Cell enrichment

With up to 2 inlet channels that are individually controlled to create different gradients, and up to 8 different outlet channels to collect your different cell population fractions.

Workflow-focused software package

With a fast and intuitive workflow you go from defining your parameters to viewing your data. The powerful tracking algorithms for the detection and measurement of cells are performed in the background while your data is being generated on screen, live.

Temperature Control

Perform your experiments under relevant conditions.

Brightfield microscopy

Low power LED illumination to image cells in a non-destructive manner.

Z-movi

The z-Movi System

Z-movi

z-Movi flow cells

Lab-on-a-chip with microfluidic channel, allowing you to easily insert both your target sample and cells of interest in a highly-controlled environment.

Cell enrichment

With up to 2 inlet channels that are individually controlled to create different gradients, and up to 8 different outlet channels to collect your different cell population fractions.

Workflow-focused software package

With a fast and intuitive workflow you go from defining your parameters to viewing your data. The powerful tracking algorithms for the detection and measurement of cells are performed in the background while your data is being generated on screen, live.

Temperature Control

Perform your experiments under relevant conditions.

Brightfield microscopy

Low power LED illumination to image cells in a non-destructive manner.

Want to learn more?

Would you like to receive exclusive news on the latest products, single-molecule events and breakthrough science from us?


You can unsubscribe at any time from our marketing emails. By submitting the form you agree to LUMICKS' privacy policy.

Take your research to the next level.

Get exclusive news on the latest products, single-molecule events and breakthrough science.

Newsletter pop up
By clicking the subscribe button you agree to LUMICKS’ privacy policy.