LUMICKS is happy to announce that a new C-Trap™ optical tweezers is now housed in the lab of Dr. Alireza Mashaghi at Leiden University, the Netherlands.
Dr. Mashaghi’s group will use the C-Trap to perform single-molecule experiments and investigate molecular folding processes. In particular, the group aims to understand how chaperones reshape the folding landscape of proteins and how protein topology affects function, dynamics, and evolution of proteins. Furthermore, chaperones are emerging as drug targets in oncology and neurology. The group will use the C-Trap to directly measure responses to pharmacological modulation of chaperone function.
“We are one of the first drug research institutes worldwide that will operate the state-of-the-art single-molecule force spectroscopy method as implemented in C-Trap. This is an exciting time for us and we hope to explore the potentials of this technology in drug research and medicine.”
Dr. Alireza Mashaghi, Leiden University
We wish Dr. Mashaghi and his team all the best of luck with their new instrument and their research!