September – December 2019

DSM Symposium Series

The 1st Dynamic Single-Molecule (DSM) Symposium  Series has come to an end. Many thanks to the speakers and the participants who joined us!

Scroll below to view the speaker list and their exclusive interviews about their research and their views on DSM analysis.

Keynote Speakers:

Simon Boulton

Francis Crick Institute and Artios Pharma

Hongbin Li

University of British Columbia

Gijs Wuite

Brije Universiteit Amsterdam

Gijsje Koenderink

Technical University of Delft

Guillermo Montoya

University of Copenhagen

Stephen Kowalczykowski

University of California, Davis

Mark Williams

Northeastern University

Erwin Peterman

Vrije Universiteit Amsterdam

Part 1 – Prof. Simon Boulton

In Part 1, we welcomed Prof. Simon Boulton, senior vice president at Artios Pharma Ltd and senior group leader at the Francis Crick Institute in London. In this video, Simon explains how he uses DSM analysis to understand homologous recombination and the mechanism of action (MOA) of inhibitors.


More information:

Understanding DNA repair using DSM experiments

Understanding MOA using DSM analysis

DSB Repair Metabolism Laboratory at Francis Crick Institute

Artios Pharma Ltd

Part 2 – Prof. Hongbin Li

In Part 2, we welcomed Prof. Hongbin Li, group leader at the University of British Columbia. Here, Hongbin discusses how he uses single-molecule force spectroscopy tools to study the mechanical properties of elastomeric proteins and discussed the impact of the DSM field.


More information:

Understanding protein folding using DSM experiments

Single Molecule AFM Laboratory at the UBC

Part 3 – Prof. Gijs Wuite

In Part 3, we welcomed Prof. Gijs Wuite, group leader at Vrije Universiteit Amsterdam and co-founder of LUMICKS. Here, Gijs explains his research and how he uses correlated optical tweezers with fluorescence microscopy to investigate processes at the single-molecule level.


More information:

Understanding DNA-protein interactions using DSM experiments

Gijs Wuite laboratory

Part 4 – Prof. Gijsje Koenderink

In Part 4, we welcomed Prof. Gijsje Koenderink, group leader at the Technical University of Delft, in the Netherlands. In this interview, Koenderink discusses how she takes a biophysical perspective to understand cell and tissue mechanics.


More information:

Understanding cell mechanics using DSM experiments

Biological Soft Matter (relocated to TUDelft)

Part 5 – Prof. Stephen Kowalczykowski

In Part 5, we welcomed Prof. Stephen Kowalczykowski, distinguised professor at the University of California, Davis. Here, Kowalczykowski explains how his group started as a biochemistry lab and adapted their studies after the single-molecule revolution.


More information:

Understanding DNA-protein interactions using DSM experiments

Kowalczykowski Lab

Part 6 – Prof. Guillermo Montoya

In Part 6, we welcomed Prof. Guillermo Montoya, professor at the University of Copenhagen and Research Director of the Protein Structure & Function Program at the Novo Nordisk Foundation Center for Protein Research. In this interview, Montoya discusses how his group complements structural protein data with molecular biophysics.


More information:

Understanding DNA-protein interactions using DSM experiments

Understanding protein folding using DSM experiments

Montoya Group

Part 7 – Prof. Mark Williams

In Part 7, we welcomed Prof. Mark Williams, Chair of the Physics Department and group leader of the Williams lab at Northeastern University. During the interview, Williams talks about his research on nucleic acid interactions and explains how single-molecule experiments translate into advances in health.


More information:

Understanding DNA-protein interactions using DSM experiments

Rediscovering Drug Research using DSM experiments

Williams Laboratory for Single Molecule Biophysics

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