September – December 2019
The 1st Dynamic Single-Molecule (DSM) Symposium Series has come to an end. Many thanks to the speakers and the participants who joined us!
Scroll below to view the speaker list and their exclusive interviews about their research and their views on DSM analysis.
Francis Crick Institute and Artios Pharma
University of British Columbia
Brije Universiteit Amsterdam
Technical University of Delft
University of Copenhagen
University of California, Davis
Vrije Universiteit Amsterdam
Part 1 – Prof. Simon Boulton
In Part 1, we welcomed Prof. Simon Boulton, senior vice president at Artios Pharma Ltd and senior group leader at the Francis Crick Institute in London. In this video, Simon explains how he uses DSM analysis to understand homologous recombination and the mechanism of action (MOA) of inhibitors.
Part 2 – Prof. Hongbin Li
In Part 2, we welcomed Prof. Hongbin Li, group leader at the University of British Columbia. Here, Hongbin discusses how he uses single-molecule force spectroscopy tools to study the mechanical properties of elastomeric proteins and discussed the impact of the DSM field.
Part 3 – Prof. Gijs Wuite
In Part 3, we welcomed Prof. Gijs Wuite, group leader at Vrije Universiteit Amsterdam and co-founder of LUMICKS. Here, Gijs explains his research and how he uses correlated optical tweezers with fluorescence microscopy to investigate processes at the single-molecule level.
Part 4 – Prof. Gijsje Koenderink
In Part 4, we welcomed Prof. Gijsje Koenderink, group leader at the Technical University of Delft, in the Netherlands. In this interview, Koenderink discusses how she takes a biophysical perspective to understand cell and tissue mechanics.
Part 5 – Prof. Stephen Kowalczykowski
In Part 5, we welcomed Prof. Stephen Kowalczykowski, distinguised professor at the University of California, Davis. Here, Kowalczykowski explains how his group started as a biochemistry lab and adapted their studies after the single-molecule revolution.
Part 6 – Prof. Guillermo Montoya
In Part 6, we welcomed Prof. Guillermo Montoya, professor at the University of Copenhagen and Research Director of the Protein Structure & Function Program at the Novo Nordisk Foundation Center for Protein Research. In this interview, Montoya discusses how his group complements structural protein data with molecular biophysics.
Part 7 – Prof. Mark Williams
In Part 7, we welcomed Prof. Mark Williams, Chair of the Physics Department and group leader of the Williams lab at Northeastern University. During the interview, Williams talks about his research on nucleic acid interactions and explains how single-molecule experiments translate into advances in health.