Identify functionally optimal TCR-engineered T cells through cell avidity measurements
In this application note, we present cell avidity obtained with the z-Movi® Cell Avidity Analyzer and in vitro experiments performed in collaboration with the team of Dr. Nathalie Rufer (University of Lausanne).
Here you will learn:
1. In contrast to affinity measured by SPR, cell avidity measurements directly correlate with T-cell functionality.
2. Avidity is a reliable parameter for the selection of top TCR candidates.
3. Cell avidity measurements with the z-Movi can accelerate the characterization of TCR-engineered T cells with anti-tumor activity and immunotherapeutic potential, through a fast and high-throughput workflow.
