Join us for an intriguing webinar that unravels the secrets of bacterial chromosome segregation.
Guided by our host, a renowned expert in bacterial cell biology, Dr. Fernando Moreno Herrero from the Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, we will explore the critical ParABS partitioning system and the SMC complex, which serve as the driving forces behind bacterial chromosome segregation.
Using cutting-edge single-molecule techniques and optical tweezers combined with a confocal microscope, we offer an exclusive view into how cytidine triphosphate (CTP) binding and hydrolysis play integral roles in the interaction between parS and ParB.
The webinar will take you through the experimental journey of discovering how ParB proteins bind specifically around parS in the presence of CTP, and intriguingly, even diffuse on distal non-specific DNA. We will further discuss the intriguing phenomenon of ‘spreading’ and the resulting DNA condensation, brought about by ParB’s spreading activity.
This webinar promises a captivating journey into the microscopic world of bacteria, revealing key mechanisms of DNA interaction, protein movement, and chromosome segregation.
Whether you’re a seasoned researcher, a budding biologist, or simply curious about the intricacies of cellular processes, this webinar is sure to pique your interest.