Publications
Cell Avidity
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Functional Avidity of Anti-B7H3 CAR T Constructs Predicts Antigen Density Threshold for Triggering Effector Function
Barisa, M. et al.
2024
BioRXiv
https://doi.org/10.1101/2024.02.19.580939
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Rational Chemical and Genetic Modifications Enhance Avidity and Function of CD70-Directed CAR T Cells for Myeloid Leukemia
Leick, M. B. et al.
2022
Cancer Cell
https://doi.org/10.1016/j.ccell.2022.04.001
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Increased Functional Potency of Multi-Edited CAR T Cells Manufactured by a Non-Viral Transfection System
O'Sullivan, A. et al.
2025
Molecular Therapy
https://doi.org/10.1016/j.omtm.2024.101389
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ZP4: A Novel Target for CAR T Cell Therapy in Triple Negative Breast Cancer
Somes, L. K. et al.
2025
Molecular Therapy
https://doi.org/10.1016/j.ymthe.2025.02.029
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Identification of potent biparatopic antibodies targeting FGFR2 fusion driven cholangiocarcinoma
Chaturantabut, S. et al.
2025
J. Clin. Investigation
https://www.jci.org/articles/view/182417
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Protocol to measure cell avidity between cord blood-derived NK cells and leukemia cell line KG-1a
Wang, Y. et al.
2024
STAR Protocols
https://www.sciencedirect.com/science/article/pii/S2666166724005525
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Bispecific CD33/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia
Boucher, J. C. et al.
2023
Molecular Therapy Oncology
https://www.cell.com/molecular-therapy-family/oncology/fulltext/S2372-7705(23)00100-6
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Advances in preclinical TCR characterization: leveraging cell avidity to identify functional TCRs
Carr, A. et al.
2024
Biological Chemistry
https://www.degruyter.com/document/doi/10.1515/hsz-2023-0341/html
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Single-Cell Acoustic Force Spectroscopy: Resolving Kinetics and Strength of T Cell Adhesion to Fibronectin
Kamsma, D. et al.
2018
Cell Reports
https://www.sciencedirect.com/science/article/pii/S2211124718313056
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Defining an Optimal Dual-Targeted CAR T-cell Therapy Approach Simultaneously Targeting BCMA and GPRC5D to Prevent BCMA Escape-Driven Relapse in Multiple Myeloma
de Larrea, C. F. et al.
2020
Blood Cancer Discovery
https://bloodcancerdiscov.aacrjournals.org/content/1/2/146
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Dual targeting with a CAR and a chimeric costimulatory receptor (CCR) enhances T cell sensitivity of tumor antigen recognition and persistence
Katsarou, A. et al.
2021
Science Translational Medicine
https://www.science.org/doi/abs/10.1126/scitranslmed.abh1962?af=R
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Sialic acid blockade in BDMCs enhances CD8+ T cell responses by facilitating high avidity DC-T cell interactions
Balneger, N. et al.
2022
Cell. Mol. Life Sci.
https://link.springer.com/article/10.1007/s00018-021-04027-x
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CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours
Larson, R. C. et al.
2022
Nature
https://www.nature.com/articles/s41586-022-04585-5
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Engineering of an avidity-optimized CD19-specific parallel chimeric antigen receptor that delivers dual CD28 and 4-1BB co-stimulation
Halim, L. et al.
2022
Front. Immunol.
https://www.frontiersin.org/articles/10.3389/fimmu.2022.836549/abstract
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Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia
Leick, M. B. et al.
2022
Cancer Cell
https://www.sciencedirect.com/science/article/abs/pii/S153561082200157X
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KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape
Li, Y. et al.
2022
Nature Medicine
https://www.nature.com/articles/s41591-022-02003-x
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IL3-zetakine combined with a CD33 costimulatory receptor as a dual CAR approach for safer and selective targeting of AML
Perriello, V. M. et al.
2022
Blood Adv.
https://ashpublications.org/bloodadvances/article/doi/10.1182/bloodadvances.2022008762/493734/IL3-zetakine-combined-with-a-CD33-costimulatory
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Acoustic force-based cell–matrix avidity measurement in high throughput
Wang, Y. et al.
2023
Biosensors
https://www.mdpi.com/2079-6374/13/1/95
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CD5 deletion enhances the antitumor activity of adoptive T cell therapies
Patel, R. P. et al.
2024
Science Immunology
https://www.science.org/doi/10.1126/sciimmunol.adn6509
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Synapse-tuned CARs enhance immune cell anti-tumor activity
Chockley, P. J. et al.
2023
Nature Biotech
https://www.nature.com/articles/s41587-022-01650-2
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Limited efficacy of APRIL CAR in patients with multiple myeloma indicate challenges in the use of natural ligands for CAR T-cell therapy
Lee, L. et al.
2023
JITC
https://jitc.bmj.com/content/11/6/e006699
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Reactivation of low avidity tumor-specific CD8+ T cells associates with immunotherapeutic efficacy of anti-PD-1
Sugiyarto, G. et al.
2023
JITC
https://jitc.bmj.com/content/11/8/e007114
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Interferon-γ couples CD8+ T cell avidity and differentiation during infection
Uhl, L. F. K et al.
2023
Nature Communications
https://www.nature.com/articles/s41467-023-42455-4
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Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Zhang, Y. et al.
2023
Molecular Cancer
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-023-01886-9#auth-Yunlin-Zhang-Aff1-Aff2
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SIGLEC-5/14 Inhibits CD11b/CD18 Integrin Activation and Neutrophil-Mediated Tumor Cell Cytotoxicity
Bouti, P. et al.
2023
Int. J. Mol. Sci
https://www.mdpi.com/1422-0067/24/24/17141
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Mesothelin CAR T-cells secreting anti-FAP/anti-CD3 molecules efficiently target pancreatic adenocarcinoma and its stroma
Wehrli, M. et al.
2024
Clin Cancer Res.
https://pubmed.ncbi.nlm.nih.gov/38393682/
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Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects
Wang, Y. et al.
2024
Molecular Cancer
https://link.springer.com/article/10.1186/s12943-024-01952-w
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Pre-Clinical Assessment of SAR442257, a CD38/CD3xCD28 Trispecific T Cell Engager in Treatment of Relapsed/Refractory Multiple Myeloma
Grab, A. L. et al.
2024
Cells
https://www.mdpi.com/2073-4409/13/10/879
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Proteomic and phenotypic characteristics of memory-like natural killer cells for cancer immunotherapy
Arellano-Ballestero, H. et al.
2024
JITC
https://jitc.bmj.com/content/12/7/e008717.long
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Venetoclax acts as an immunometabolic modulator to potentiate adoptive NK cell immunotherapy against leukemia
Wang, Y. et al.
2024
Cell Reports Medicine
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00272-6
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Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma
O’Connell, R. P. et al.
2024
JITC
https://jitc.bmj.com/content/12/6/e008733
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The BTLA-HVEM axis restricts CAR T cell efficacy in cancer
Guruprasad, P. et al.
2024
Nature Immunology
https://www.nature.com/articles/s41590-024-01847-4
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Selective targeting of oncogenic hotspotmutations of the HER2 extracellular domain
Bang, I. et al.
2024
Nature Chemical Biology
https://www.nature.com/articles/s41589-024-01751-w.epdf
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Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function
Barden, M. et al.
2024
JITC
https://jitc.bmj.com/content/12/12/e010208
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Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells
Gad, Z. A. et al.
2025
Science Advances
https://www.science.org/doi/10.1126/sciadv.adq8114
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ARI0003: Co-transduced CD19/BCMA dual-targeting CAR-T cells for the treatment of non-Hodgkin lymphoma
Bachiller, M. et al.
2024
Molecular Therapy
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(24)00755-X
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TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens
Huang, D. et al.
2024
Cell Reports
https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01300-7
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