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Avidion

True binding. 
Better therapies.

Ideal for cell therapy candidate screening and large characterization studies. Run up to 4 disposable 48-well cartridges a day for a total of 192 measurements with <80 min. hands-on time.

High throughput

High throughput measurements with 96-well plate compatibility

Hands-off

Minimal hands-on time through automated handling and deep-learning analysis

Multiplexed

Multiplexed insights through 4-color fluorescence readouts

Introduction video

Prepare for cellular lift-off

Take a look at our introduction video to learn everything about Avidion
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Workflow

Easy to use, impactful results

Measure the overall strength of interaction between cells or between proteins and cells, quickly and easily.

Introduce your target cells using standard well plates

Load up to 4 cartridges of target cells, adherent or non-adherent, using standard 96-well plates. Avidion automatically transfers the cells and ensures proper incubation through various checks.

Add your media and effector cells, up to 192 per day.

Introduce up to 192 fluorescently labeled effector cells in separate 96-well plates. Avidion automatically introduces them to your target cells, handling incubation and timing.

Let Avidion execute your measurements

Let the Cell Avidity measurement begin. Through a sequence of multicolor fluorescence imaging and centrifugal force application, true cell binding is revealed.

View your results and start planning for tomorrow.

Get direct access to Cell Avidity insights thanks to Avidion's powerful AI-accelerated on-board analysis. With disposable cartridges and automated self-cleaning, you can shift your attention to your next experiment.

Multiplexing features

Multiplex your colors, Multiply your insights.

Staining with small molecules

Unlock deeper insights with signal-specific gating

Activation and viability markers can be used to add functional context to your studies as well as achieve excellent data quality.

Figures: Jurkat cells on Nalm6 were kept too long in culture medium to create artificially high concentrations of dead cells. Apoptotic and necrotic cells were labelled with Caspase and Sytox, respectively. The bar plot shows that gating apoptotic and necrotic cells enhances the Cell Avidity measurement, as would be expected.

Staining of surface receptors with antibodies

Differentiate subpopulations with precision

Measuring Cell Avidity across phenotypes is made possible through characterizing subpopulations like CD4/CD8 T cells or memory versus effector states.

Figures: Purified CD4+ and CD8+ cells were mixed and expanded in culture for 14 days.​ CD8 antibody PerCP-Cyanine5.5 and CD4 antibody FITC were used together with Cell Trace dye.​ CD4+ and CD8+ cells were gated and the bar plot shows cell avidity for each subpopulation.

Detection of fluorescent proteins

Streamline transduction analysis without extra staining

Fluorescent protein expression can be leveraged in order to assess CAR levels and co-expression markers.

Figures: Endogenous expression of GFP was measured in CD8 primary T cells.
Throughput

Screen 192 samples within 80 min. hands-on time

800 cells

Up to 800 cells analyzed per well

4 colors

Cell Avidity + 3-color fluorescence for multiplexed insights

48-well cartridge

Up to 48 wells per Avidion cartridge

192 samples per day

Run up to 4 cartridges per experiment within 80 min. hands-on time

Case study

How many Cell Avidity measurements can you do in a day? A good example is a CAR-T cell screening project performed in collaboration with Professor Dirk Busch at Technical University Munich, using Avidion. In just half a day, it is possible to test and rank 20 CAR constructs.

Rapid screening
20 Jurkat CAR constructs screened in a single day. Each sample was measured with 4 technical replicates.
Cost and time efficiency
Early, robust identification of top candidates
Repeatable and reproducible results
Tight error bars and SDs confirm assay robustness.
Dirk Busch, PhD
Professor
Technical University of Munich
Platform

Take a look inside

Discover the advanced technology and engineering that makes Avidion possible

Robotic cartridge handling

Seamlessly moves your cells through all of the Avidion's compartments, delivering near hands-free operation.

Liquid handling system

Automatically manages media exchanges and reagent additions, ensuring consistent and reproducible biology.

Deep-learning enabled graphical processing

Delivers exceptional data quality through automated, intelligent quantification, ready for you right after your experiment.

Centrifuge

Gently applies a controlled force to assess multi-receptor binding, distinguishing strong interactions from weaker ones.

Multicolor fluorescence imaging

Unlocks multiplex imaging and enables unified experiments including cell population phenotyping, receptor expression, and transduction efficiency.

Incubator

Ensures optimal conditions for your target cells in preparation for your experiment.

Software

Your new data acquisition and analysis experience

Design, execute and analyze your experiment with ease and confidence. Our software delivers an intuitive experience combined with powerful algorithms for the most complex binding behavior.

Design and prepare your experiment with ease

Design the perfect experiment with our intuitive interface. You’ll receive a lear overview of experiment phases, reagents and well plate layouts.

Enjoy an automated workflow with minimal hands-on time

Make use of our guided experience with clear actions and information presented throughout your whole experiment.

Obtain immediate insights and study them wherever, whenever

Your data is ready straight after the experiment. Study and analyze it from the comfort of your desk, or home.
Key content

Download the brochure

Get the latest all-in-one overview

Avidion Product Brochure
Avidion Product Brochure
Brochure
The latest all-in-one overview of Avidion’s features, options, and specifications.
Brochure
Benefits

Beyond the product

Take a look at the perks that come with being one of our users

Symposia

Join the community

BIT (Breakthroughs in Immunology) is LUMICKS’ symposia format. We regularly host events across the world, aiming to bring together scientists interested in Cell Avidity to share their research, connect, and exchange ideas and experiences.

Support & service

Your success is our success

Our goal is to minimize your time to results, ensure success, and provide instruments that are easy to use and maintain. To this end we have dedicated teams providing user training, application support and system check-ups.

Adopting Cell Avidity

Let’s begin your LUMICKS journey

Our experts are ready to learn about your research challenges and see where our technologies can bring value.

Contact us

Demonstrating value

Our application scientists can help create interest among potential users through organizing different events such as seminars, workshops, and demonstrations, as well as meet with stakeholders individually to understand and help solve their needs.

Avidigo services

At our Amsterdam headquarters, our internal Avidigo service team supports academic and industry clients looking to integrate Cell Avidity into their workflows and pipeline. From experimental design to data analysis and interpretation, we support you all the way.

Grant & tender support

Throughout our history we have supported multiple successful grants across a broad spectrum of funding and users involved. Our application scientists are experienced in highlighting the unique value of Cell Avidity and its solutions.