PhD Student – Dynamic-single-molecule

Full-time position


LUMICKS is looking for a motivated and pro-active student enthusiastic about pursuing a PhD in the field of single-molecule analysis. You will join the European CohesiNet consortium together with 11 other doctoral candidates to work on the Horizon Europe Marie Skłodowska-Curie Doctoral Network “Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases”. The position will last 36 months, and you will be working at LUMICKS and the VU University Amsterdam. The scientific supervision and embedding is conducted by scientists from the VU University Amsterdam.

You will develop novel biochemical tools for investigation of the molecular mechanisms of cohesin using fluorescence microscopy combined with single-molecule optical tweezers spectroscopy. You will study chromatin organization regulated by cohesin and its function in biological processes and diseases. In collaboration with other PhD candidates and institutes of the consortium, you will study the dynamics cohesin complex assembly, their binding onto DNA substrates and the mechanics of cohesin-induced higher-order DNA structures. To study cohesin in a hierarchy of complex environments, you will develop assays using nucleosomes, chromatin fibers and full chromosomes.

Working with a wide range of experts in the CohesiNet program will give you the best chance to make a strong impact on our fundamental understanding of cohesin and chromosome organization. Doing this research in the context of LUMICKS will ensure optimal dissemination of your results and will provide you a unique perspective on potential future career paths.

Eligible candidates:
Have not been resident or have conducted main activity (studies, work, etc.) in the Netherlands for more than 12 months within the last three years.
Have not been awarded a doctoral degree.
Are fluent in English

Location: Amsterdam, The Netherlands

Apply now Meet LUMICKS

What are my tasks & responsibilities?

  • You are proactive and undertake the necessary efforts to ensure good progress in your doctoral research project;
  • You actively engage in setting up the research questions in your doctoral project in line with the goals of the CohesiNet project and LUMICKS strategy;
  • You are jointly responsible for developing the research methodology that will be used to address your research questions;
  • You are responsible for planning, implementing and, where necessary, modifying your research;
  • You are responsible for interpreting and analyzing your research results, to frame your research in a broader context, and to reflect critically on the research process;
  • Together with your supervisory team, you ensure that you communicate and share your doctoral research results (e.g., in publications and/or other scientific communications.

What about my skills & competencies?

  • You are Highly motivated, ambitious and creative;
  • Prior experimental work and proven skills in one or more of these areas are highly desirable: cell biology, molecular biology, biochemistry;
  • You have a strong practical knowledge of data analysis and interpretation;
  • You have excellent communication, presentation and organizational skills, ability to work in an interdisciplinary team and willingness to work outside the core expertise;
  • Experience with microscopy and/or single-molecule methods is an advantage.


LUMICKS has come to market as the supplier of instruments for dynamic single-molecule and cell avidity research – a rapidly evolving niche in the fundamental biology research field. Our high-performance instruments allow for the investigation into the fundamental cause of disease and potential for drug optimization. With our tools researchers can visualize and quantify the interactions between proteins and DNA in real-time, and perform high-throughput screening of molecular and cell-cell interactions using sound waves.

We offer the chance to be part of an important mission: To improve human health by unlocking dynamic single-molecule and cell avidity analysis. With an ever-increasing adoption of our technologies by leading institutes and biotech’s from all over the world, including UC Berkeley, Max-Planck, Rockefeller University and Takeda Pharmaceuticals, LUMICKS is now expanding its team

Why Join?

Autonomy, ownership & responsibility

Be the leader of your own projects, and own them like no other. Whether you’re developing software or business, you are responsible for your work and the direction it goes.

Growth opportunities

With new positions opening up weekly and the company still growing exponentially, there are lots of opportunities to broaden your skill set.

Flat organization & open culture

At LUMICKS engagement is key. We try to align everyone on our dreams and strategies to unlock single-molecule and single-cell research.

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