LUMICKS is looking for a motivated and pro-active student enthusiastic about pursuing a PhD in the field of single-molecule analysis. You will join the European CohesiNet consortium together with 11 other doctoral candidates to work on the Horizon Europe Marie Skłodowska-Curie Doctoral Network “Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases”. The position will last 36 months, and you will be working at LUMICKS and the VU University Amsterdam. The scientific supervision and embedding is conducted by scientists from the VU University Amsterdam.
You will develop novel biochemical tools for investigation of the molecular mechanisms of cohesin using fluorescence microscopy combined with single-molecule optical tweezers spectroscopy. You will study chromatin organization regulated by cohesin and its function in biological processes and diseases. In collaboration with other PhD candidates and institutes of the consortium, you will study the dynamics cohesin complex assembly, their binding onto DNA substrates and the mechanics of cohesin-induced higher-order DNA structures. To study cohesin in a hierarchy of complex environments, you will develop assays using nucleosomes, chromatin fibers and full chromosomes.
Working with a wide range of experts in the CohesiNet program will give you the best chance to make a strong impact on our fundamental understanding of cohesin and chromosome organization. Doing this research in the context of LUMICKS will ensure optimal dissemination of your results and will provide you a unique perspective on potential future career paths.
Requirements:
Eligible candidates:
Have not been resident or have conducted main activity (studies, work, etc.) in the Netherlands for more than 12 months within the last three years.
Have not been awarded a doctoral degree.
Are fluent in English
Location: Amsterdam, The Netherlands
