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Symposium

SMBio UK & Ireland 2025

Single molecules. Joint research.
May 14, 2025
Oxford, United Kingdom
Dorothy Crowfoot Hodgkin building, South Parks Road, OX1 3QU

Welcome to a new Symposium

Following the great success of the 2024 event, the University of Oxford, LUMICKS, and additional sponsors proudly present the second UK-Ireland symposium focusing on single-molecule research! Featuring keynotes, talks, posters and discussions, the 2-day event aims to bring together scientists interested in single-molecule approaches to biology from all over the UK and Ireland to share their research, connect, and exchange ideas and experiences. This event is fully booked. You can join the waiting list and we'll let you know when a space has opened up!

Organized by

Nynke Dekker, PhD
Statutory Professor of Biophysics
University of Oxford
Achillefs Kapanidis, PhD
Professor
Mina Brett-Pitt, PhD
Senior Sales Manager
LUMICKS

Keynote speakers

David Rueda, PhD
Professor and Chair
Imperial College London
Suliana Manley, PhD
Professor
EPFL
Sebastian Deindl, PhD
Professor
Uppsala University
Ralf Jungmann, PhD
Professor
LMU Munich

Agenda

| | Wednesday 14th May | | :--- | :--- | | 11:00 - 11:30 | Registration and coffee | | 11:30 - 12:15 | **Key Note Lecture 1: Prof. David Rueda - MRC-LMS**
**Decoding Cas9 Specificity: How DNA Topology Shapes Precision** | | 12:15 - 13:15 | Lunch | | 13:15 - 13:35 | Matt Schaich - Pittsburgh - *Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks* | | 13:35 - 13:55 | Maxim Molodtsov - Francis Crick Inst. - *Mechanism of DNA loop extrusion by the cohesin complex* | | 13:55 - 14:15 | Linyu Zuo - MRC LMB - *Single molecule imaging of FET fusion oncoproteins loci-specific condensates* | | 14:15 - 14:25 | Sponsor talk 1 - LUMICKS | | 14:25 - 15:00 | Coffee Break | | 15:00 - 15:20 | Erin Cutts - Sheffield - *Single Molecule Visualisation of Human Topoisomerase 2A Decatenation Reveals Substrate Requirements* | | 15:20 - 15:40 | Adam Cawte - Oxford - *Single-molecule RNA imaging reveals persistent association with chromatin facilitates the spreading and retention of Xist RNA on the inactive X-chromosome* | | 15:40 - 16:00 | Tania Mendonca - Nottingham - *Tweezing the mitotic chromosome periphery, a fluid coat that modulates chromosome mechanics* | | 16:00 - 16:30 | Coffee Break | | 16:30 - 17:15 | **Key Note Lecture 2: Prof Suliana Manley - EPFL Lausanne**
**Chromosome decoupling in two ancient relatives: mitochondria and alphaproteobacteria** | | 17:15 - 18:45 | Drinks and poster session 1 | | 19:00 - 20:30 | Dinner Reception | | | Thursday 15th May | | :--- | :--- | | 09:00 - 09:45 | **Key Note Lecture 3: Prof. Ralf Jungmann - LMU Munich, Max Planck**
**From DNA Nanotechnology to biomedical insight: Towards single-molecule spatial omics** | | 09:45 - 10:05 | Somenath Bakshi - Cambridge - *Time-resolved measurement of phage infection cycles in individual bacterial cells* | | 10:05 - 10:25 | Sabrina Simoncelli - UCL - *Expanding the capabilities of SMLM with spinning disk confocal optical photon reassignment* | | 10:25 - 10:45 | Paolo Annibale - St Andrews - *Membrane receptor dynamics on pulled tethers from single cells* | | 10:45 - 11:05 | Sergi Garcia - KCL - *Talin oxidation regulates cellular mechanotransduction* | | 11:05 - 11:25 | Coffee Break | | 11:25 - 11:45 | Mark Szczelkun - Bristol - *ATP-driven motor proteins as defenders against DNA uptake by bacteria* | | 11:45 - 12:05 | Karolina Chabowska - Francis Crick Inst. - *Real-time single-molecule visualisation of the human replisome* | | 12:05 - 12:25 | Zhaowei Liu - Oxford - *Single-molecule investigation of CMG-nucleosome interactions* | | 12:25 - 12:45 | Jagadish Hazra - Oxford - *Elucidating sequence-dependence in transcription initiation using a novel single-molecule fluorescence-based sequencing technique* | | 12:45 - 13:05 | Nicole Robb - Warwick - *smFRET to uncover RNA-viral protein interactions* | | 13:05 - 13:15 | Sponsor talk 2 - ONI | | 13:15 - 14:45 | Lunch and poster session 2 | | 14:45 - 15:05 | Ulrich Keyser - Cambridge - *Native RNA analysis using nanopores: Isoforms, transcription termination and RNA modifications* | | 15:05 - 15:25 | Madhavi Krishnan - Oxford - *Single-molecule stereometry* | | 15:25 - 15:45 | Philipp Kukura - Oxford - *Towards quantitative and universal single molecule biophysics with mass photometry* | | 15:45 - 16:05 | Coffee Break | | 16:05 - 16:50 | **Key Note Lecture 4: Prof. Sebastian Deindl - Uppsala**
**From sequence to function: bridging single-molecule kinetics with molecular Identity** | | 16:50 - 17:00 | Closing remarks - poster awards |
Day 1, Monday 17 March
12:30 - 1:00 PMRegistration and coffee/snacks
12:30 - 1:00 PMRegistration and coffee/snacks
12:30 - 1:00 PMRegistration and coffee/snacks
Day 1, Monday 17 March
12:30 - 1:00 PMRegistration and coffee/snacks
12:30 - 1:00 PMRegistration and coffee/snacks
12:30 - 1:00 PMRegistration and coffee/snacks
Day 1, Monday 17 March
12:30 - 1:00 PMRegistration and coffee/snacks
12:30 - 1:00 PMRegistration and coffee/snacks
12:30 - 1:00 PMRegistration and coffee/snacks

Brought to you by

And our sponsors

Pricing

What’s SMBio?

The SMBio single-molecule biology symposium is a 2-day event, bringing together scientists interested in single-molecule approaches to biology from all over the world to share their research, connect, and exchange ideas and experiences.

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