Single-Molecule Job Board

Academic, research and science jobs in the single-molecule field

Open Positions

Post doc | London, UK

The Cell Cycle Research group at the MRC London Institute of Medical Sciences in London, UK, is looking for a Postdoctoral Research Scientist to join them. There, you will have the opportunity to work on a project aimed to study protein-DNA interactions of chromosomal architectural proteins that lead to the formation of three-dimensionally folded chromosomes. Experience in biochemistry (protein purification/structural analysis) and biophysics (single molecule – optical/magnetic tweezers) is essential, although some training will be provided. You will need a PhD in life sciences or equivalent experience and at least one first-author publication published or in press.

Post-doc | London, UK

The research group of Professor David Rueda has an opening for a postdoctoral researcher in the exciting area of eukaryotic chromatin remodelling at the single-molecule level. This project provides the unique opportunity to work with reconstituted eukaryotic chromatin remodellers to investigate their molecular mechanism from a quantitative mechanistic point of view. Candidates should have experience in biophysics or quantitative biochemistry.

For additional information, please contact Prof. David Rueda at david.rueda ‘at’ Apply online here.

Post doc | Delft, the Netherlands

We have an opening for a postdoctoral researcher in the exciting area of understanding the mechanisms of eukaryotic replication at the single-molecule level. This project provides you the unique opportunity to work with reconstituted eukaryotic systems and to explore their functioning from a quantitative mechanistic point of view. Candidates should have experience in biophysics or quantitative biochemistry.

Please send your cover letter with motivation, full CV, and the names and contact information of three references to Prof. Nynke Dekker at n.h.dekker ‘at’

PhD Position | Hannover, Germany

The Institute of Molecular and Cell Physiology, Medical School Hannover is looking for talented and motivated PhD candidate (m/f/d) of all nationalities with an interest in biophysics, cell biology, molecular biology and nanotechnology. The project aims to investigate functional changes in the b-MHC motor properties, induced by HCMmutations, using state-of-the-art single molecule function investigation techniques, such as total internal reflection fluorescence microscopy (TIRF) and optical tweezers.

Application deadline: 25th July 2019, the project will start at the earliest possible date

Post-doc | London, UK

An ERC funded postdoctoral position is now available in the laboratory of Alessandro Costa. We are looking for a highly motivated researcher to study the mechanism of chromosome replication using in vitro reconstitution and cryo-electron microscopy. The successful candidate will use a range of techniques including biochemistry, structural mass spectrometry, and cryo-electron microscopy to elucidate the mechanism of replisome progression in eukaryotes. Please visit the lab website for more information about this research. The successful candidate will have expertise in mechanistic biochemistry and/or structural biology and a PhD in a relevant area (or be in the final stages of completion).

The advert closing date is March 1, 2019.

Post-doc | Chicago, IL, USA

The Zhou lab at the University of Illinois Chicago is recruiting a postdoc with experience in single-molecule instruments. Our lab is equipped with an advanced optical-tweezer instrument from LUMICKS. We are interested in a wide range of studies on intrinsically disordered proteins, including binding kinetics, conformations and dynamics under macromolecular crowding, and physical properties of protein droplets formed by liquid-liquid phase separation. To apply, please send CV and names of three references to

Post-doc | Leiden, the Netherlands

Leiden University invites applications for a post-doctoral fellow in the Faculty of Science, at the Mashaghi lab. The postdoctoral fellow will design and perform single-molecule experiments to understand biomolecular folding processes. The ideal candidate will have a Ph.D. in physics (experimental and/or theoretical) or engineering with a strong publication record. The Mashaghi lab is a part of the Leiden Academic Centre for Drug Research (LACDR), one of Europe’s premier drug research institutes. The lab is involved in interdisciplinary research at the interface of physics, engineering, and biomedicine.

Please inquire at

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