Single-Molecule Job Board
Academic, research and science jobs in the single-molecule field
Optical Microscopy Specialist | ERC Synergy Project in the Intracellular Self-Organization Group, Barcelona, Spain
Optical microscopy and image analysis play a central role in the research of the Intracellular Self-Organization lab, headed by Thomas Surrey. The successful candidate will be a key lab member involved in several projects and responsible for developing light microscopy methods (iSCAT/IRM, laser ablation, optical trapping) and image and data analysis tools within the ERC Synergy Project BIOMECANET. The selected candidate will work with biochemists and biophysicists, contributing specialized microscopy and data analysis expertise and training. The research will address fundamental questions concerning the molecular mechanisms governing the cytoskeleton spatiotemporal organization during cell division, using reconstituted systems and cultured cells.
The lab of Prof. Gijsje Koenderink is looking for someone to study the physics of cell division through synthetic cells in a 2 year-long postdoc. The aim of this project is to ask the question: how does the membrane geometry determine the assembly and constriction of the actin ring? Models suggest that actomyosin ring formation and furrow ingression sensitively depend on the cell geometry and the balance between cortical tension at the cell equator and the poles. Some models predict that contractile ring initiation furthermore requires cooperation with lipids and proteins that promote membrane curvature. To experimentally test these ideas, you will reconstitute synthetic cells by encapsulating the minimal machinery required for actin ring assembly inside lipid vesicles and use microfluidic devices, optical tweezers, and curvature-inducing proteins to impose a controlled membrane geometry. To measure the dynamic response of the actin and the membrane, you will make extensive use of confocal fluorescence imaging, FCS, FRAP, and single-molecule imaging.
The five PhD students will form an interdisciplinary team, spread across five labs – including the single-molecule optical tweezers lab of Dr. Kasia Tych – and will exploit some of the latest state-of-the-art methods comprising both experimental and computational approaches in their research, with lots of opportunities for excellent and ground-breaking science, and a great learning experience in a very nice team. Please submit all applications before March 31, 2021.
At the newly-founded group of Dr. Raya Sorkin, Department of Physical Chemistry, School of Chemistry, Tel Aviv University, Israel, https://sorkinraya.wixsite.com/sorkinlab
The aim of the two projects is to reveal the role and action mechanisms of fusion-mediating proteins in the process of membrane fusion, using a combination of single-molecule techniques (including optical tweezers and AFM). Two positions are available: to study membrane fusion in fertilization as well as membrane fusion during viral infection. The approach includes developing controlled model systems, such as micro-beads coated with membranes of defined composition with incorporated proteins of interest, to quantitatively study protein-protein and protein-membrane interactions.
The Banerjee Lab at University at Buffalo is seeking a biophysicist/biochemist/polymer physicist/polymer chemist/biologist to join them as postdoc and study liquid-liquid phase separation of intrinsically disordered proteins and RNAs. Research duties include, but are not limited to:
Application of correlative optical tweezer and confocal fluorescence microscopy to study biomolecular condensates.
High-throughput phase separation assay development, and quantifying nucleic acid-protein interactions.
BIOmolecular Nanosystems with ever-Increasing Complexity & Size LABoratory (BIONICS LAB), also known as Hariadi lab is eager to recruit 2 postdocs who are interested in a multi-disciplinary approach to studying non-equilibrium organization of biomolecular systems. Applicants with expertise in at least one of these areas: (i) DNA nanotechnology, (ii) super-resolution mcroscopy, (iii) molecular biology (e.g., cytoskeleton, molecular motors), (iv) cryo electron microscopy, and (v) virology are encouraged to apply.
A Ph.D. position in the laboratory of Prof. Scott Blanchard at St. Jude Children’s Research Hospital is available.
Research in the Blanchard laboratory focuses on examining structure-function relationships in macromolecular assemblies, including bacterial and human ribosomes as well as integral membrane proteins, using a variety of genetic, biochemical, and spectroscopic approaches.
Applicants with a physics background who are enthusiastic and hardworking are encouraged to apply.
– Bachelor’s or master’s degree in biophysics, physics, chemistry, or a related field.
– Self-motivated with a strong work ethic.
– Ability to work independently as well as collaboratively.
Additional desirable qualifications:
– Proficiency with optical instrumentation.
– Proficiency in MatLab or Labview programming.
– Proficiency in data analysis.
Applicants should send a curriculum vitae, the names and email addresses of three references, as well as a brief statement on how their experience and goals relate to our work to Scott.Blanchard@STJUDE.ORG.
At St. Jude, we have one common goal: find cures for children with cancer and other life-threatening diseases through research and treatment. We seek talented and diverse faculty and staff to continue to provide superior care, leading-edge research, and unmatched resources at no cost to the family.
As an integral part of the Chinese efforts to build first-rate universities, the Center for Life Sciences (CLS) was established in 2011 at Tsinghua and Peking Universities. It is supported by the central government through the Ministry of Education (MOE), the Ministry of Science and Technology (MOST) and the Ministry of Finance (MOF). Collaboration in research will be highly encouraged among scientists from the two universities. At each university, the center will anchor faculty members distributed in multiple schools and departments, ranging from biology, chemistry, physics, engineering, to psychology and medicine, nurturing interdisciplinary interactions. The center expects its independent laboratories led by principal investigators to pursue important scientific questions. Applications are invited for Principal Investigator (PI) at Center for Life Sciences. They are recruiting scientists with the best potential to carry out creative research of long-term significance in the life sciences; positions are open at all ranks from Assistant, Associate and Full Investigatorship positions.
The Kaplan Lab has several openings for students interested in a PhD in experimental single-molecule biophysics.
Physics students: The position involves design and construction of an advanced optical setup combining optical manipulation and fluorescence detection, and its use to characterize the interplay between chromatin dynamics and gene expression.
Biology students: The position combining molecular biology and high resolution, single-molecule optical tweezers to study the interactions between transcription factors, polymerases, and chromatin.
The lab is a highly interdisciplinary one, and students can expect to acquire a wide set of skills during their studies. The Technion – Israel Institute of Technology is located in the beautiful city of Haifa, on the Mediterranean coast.
Some recent works from the lab:
Rudnizky et. al., PNAS (2019),
Zananbiri et. al., eLife (2019),
Rudnizky et. al., Nature Communications (2016)
Located at the Single Molecule Mechano-Biology Lab, a part of the department of chemistry at UBC Okanagan. Students will work in a close-knit team on interdisciplinary single-molecule and single-cell research projects. We have projects in a variety of research areas including (but not limited to): 1. biosensor design and development, 2. bacterial and cancer cell adhesion, and 3. new biophysical technique development.
The Finzi-Dunlap lab and the C-Trap facility at Emory University seek a motivated experimentalist to study transcriptional regulation, and supervise the use of the new NSF/Emory-sponsored C-Trap microscope from LUMICKS which combines optical tweezers, single-molecule fluorescence detection, and microfluidics. The position is a unique opportunity to do cutting edge research and collaborate with a variety of exceptional investigators.
We have an opening for a postdoctoral researcher in the exciting area of understanding the mechanisms of eukaryotic replication at the single-molecule level. This project provides you the unique opportunity to work with reconstituted eukaryotic systems and to explore their functioning from a quantitative mechanistic point of view. Candidates should have experience in biophysics or quantitative biochemistry.
Please send your cover letter with motivation, full CV, and the names and contact information of three references to Prof. Nynke Dekker at n.h.dekker ‘at’ tudelft.nl.
The Zhou lab at the University of Illinois Chicago is recruiting a postdoc with experience in single-molecule instruments. Our lab is equipped with an advanced optical-tweezer instrument from LUMICKS. We are interested in a wide range of studies on intrinsically disordered proteins, including binding kinetics, conformations and dynamics under macromolecular crowding, and physical properties of protein droplets formed by liquid-liquid phase separation. To apply, please send CV and names of three references to firstname.lastname@example.org.
Leiden University invites applications for a post-doctoral fellow in the Faculty of Science, at the Mashaghi lab. The postdoctoral fellow will design and perform single-molecule experiments to understand biomolecular folding processes. The ideal candidate will have a Ph.D. in physics (experimental and/or theoretical) or engineering with a strong publication record. The Mashaghi lab is a part of the Leiden Academic Centre for Drug Research (LACDR), one of Europe’s premier drug research institutes. The lab is involved in interdisciplinary research at the interface of physics, engineering, and biomedicine.
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